Results 71 to 80 of about 2,019,877 (178)

Moderate SIRT1 overexpression protects against brown adipose tissue inflammation

Molecular Metabolism, 2020
Objective: Metainflammation is a chronic low-grade inflammatory state induced by obesity and associated comorbidities, including peripheral insulin resistance.
Carmen Escalona-Garrido, Patricia Vázquez, Paula Mera, Sebastián Zagmutt, Ester García-Casarrubios, Ana Montero-Pedrazuela, Fernanda Rey-Stolle, Ana Guadaño-Ferraz, Francisco J. Rupérez, Dolors Serra, Laura Herrero, Maria Jesus Obregon, Ángela M. Valverde   +12 more
doaj   +1 more source

Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria

Archives of Toxicology, 2015
The metabolically inert perfluorinated fatty acids perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) can display fatty acid-like activity in biological systems.
I. Shabalina, A. Kalinovich, B. Cannon, J. Nedergaard   +3 more
semanticscholar   +1 more source

Acute induction of uncoupling protein 1 by citrulline in cultured explants of white adipose tissue from lean and high-fat-diet-fed rats

Adipocyte, 2015
A diet enriched with citrulline (CIT) reduces white adipose tissue (WAT) mass. We recently showed that CIT stimulated β-oxidation in rat WAT explants from young (2–4 months) but not old (25 months) rats.
Nolwenn Joffin, A. Jaubert, J. Bamba, R. Barouki, P. Noirez, C. Forest   +5 more
semanticscholar   +1 more source

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

Molecular Metabolism, 2015
Objective Circulating fibroblast growth factor 21 (FGF21) is an important auto- and endocrine player with beneficial metabolic effects on obesity and diabetes.
S. Keipert, Maria Kutschke, D. Lamp, Laura Brachthäuser, F. Neff, C. Meyer, Rebecca Oelkrug, A. Kharitonenkov, M. Jastroch   +8 more
semanticscholar   +1 more source

A novel model for proton transport mediated by uncoupling protein 1

Protein Science
Abstract Uncoupling Protein 1 (UCP1) is a mitochondrial protein which drives thermogenesis in brown adipose tissue. UCP1 facilitates the dissipation of the proton gradient as heat and plays a critical role in energy expenditure and metabolic regulation.
Luise Jacobsen, Sneha Menon, Michael James Gaudry, Ali Asghar Hakami Zanjani, Peter Reinholdt, Martin Jastroch, Himanshu Khandelia   +6 more
openaire   +4 more sources

Ginsenoside Rg1 promotes browning by inducing UCP1 expression and mitochondrial activity in 3T3-L1 and subcutaneous white adipocytes

Journal of Ginseng Research, 2019
Background: Panax ginseng Meyer is known as a conventional herbal medicine, and ginsenoside Rg1, a steroid glycoside, is one of its components. Although Rg1 has been proved to have an antiobesity effect, the mechanism of this effect and whether it ...
Kippeum Lee, Young-Jin Seo, Ji-Hyoen Song, Sungwoo Chei, Boo-Yong Lee   +4 more
doaj   +1 more source

Uncoupling Protein 1 and Sarcolipin Are Required to Maintain Optimal Thermogenesis, and Loss of Both Systems Compromises Survival of Mice under Cold Stress*

Journal of Biological Chemistry, 2015
Background: The mechanisms underlying UCP1-independent thermogenesis are not well understood. Results: Loss of both SLN and UCP1 results in compromised thermogenic ability and severe sensitivity to acute cold.
Leslie A. Rowland, N. Bal, L. Kozak, M. Periasamy   +3 more
semanticscholar   +1 more source

Capsinoids suppress diet-induced obesity through uncoupling protein 1-dependent mechanism in mice

, 2015
Capsinoids are less pungent capsaicin analogues that increase whole body energy expenditure and hence reduce fat. Several studies have suggested that capsinoids activate brown adipose tissue (BAT), a major site of adaptive thermogenesis, but the actual ...
Y. Okamatsu-Ogura, Ayumi Tsubota, Kana Ohyama, Y. Nogusa, M. Saito, K. Kimura   +5 more
semanticscholar   +1 more source

Expression, Folding, and Proton Transport Activity of Human Uncoupling Protein-1 (UCP1) in Lipid Membranes

Journal of Biological Chemistry, 2013
Background: UCP1 transports protons across the inner mitochondrial membrane and generates heat. Results: Oligomeric forms of UCP1 transported protons across phospholipid bilayers and the conformation and proton transport activity were affected by ...
T. Hoang, Matthew D. Smith, M. Jelokhani-Niaraki   +2 more
semanticscholar   +1 more source

Opposite regulation of uncoupling protein 1 and uncoupling protein 3 in vivo in brown adipose tissue of cold‐exposed rats

FEBS Letters, 2002
Earlier we reported a 14‐fold increase of glycogen in the brown adipose tissue (BAT) in rats when the animals were placed back from cold to neutral temperature. To elucidate the mechanism, here we compared the level of glucose transporter 4 (GLUT4) protein, uncoupling protein (UCP) 1 and UCP3 mRNA and protein expressions in the BAT under the same ...
Jakus, P.B, Sipos, K, Kispal, G, Sandor, A   +3 more
openaire   +2 more sources