Results 51 to 60 of about 2,019,877 (178)

Test systems to study the structure and function of uncoupling protein 1: a critical overview

Frontiers in Endocrinology, 2011
The discovery of active brown adipose tissue (BAT) in healthy adult humans has renewed interest in the biology of this organ. BAT is capable of distributing nutrient energy in the form of heat allowing small mammals to efficiently defend their body ...
Verena eHirschberg, Tobias eFromme, Martin eKlingenspor   +2 more
doaj   +1 more source

Fatty Acids Change the Conformation of Uncoupling Protein 1 (UCP1) [PDF]

Journal of Biological Chemistry, 2012
UCP1 catalyzes proton leak across the mitochondrial inner membrane to disengage substrate oxidation from ATP production. It is well established that UCP1 is activated by fatty acids and inhibited by purine nucleotides, but precisely how this regulation occurs remains unsettled.
Ajit S, Divakaruni, Dickon M, Humphrey, Martin D, Brand   +2 more
openaire   +2 more sources

The Therapeutic Potential of Brown Adipocytes in Humans

Frontiers in Endocrinology, 2015
Obesity and its metabolic consequences represent a significant clinical problem. From a thermodynamic standpoint, obesity results from a discord in energy intake and expenditure.
Craig ePorter, Craig ePorter, Maria eChondronikola, Maria eChondronikola, Labros S Sidossis, Labros S Sidossis, Labros S Sidossis   +6 more
doaj   +1 more source

Identification of serine phosphorylation in mitochondrial uncoupling protein 1

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2008
Native uncoupling protein 1 was purified from rat brown adipose tissue of cold-acclimated rats and rats kept at room temperature, in the presence of phosphatase inhibitors. The purified protein from cold-acclimated animals was digested with trypsin and immobilized metal affinity chromatography was used to select for phosphopeptides.
Carroll, Audrey M., Porter, Richard K., Morrice, Nick A.   +2 more
openaire   +2 more sources

Brown adipose tissue in adult humans: A mini review

Journal of Clinical and Scientific Research, 2019
Adipose tissue is of two types: white adipose tissue (WAT) and brown adipose tissue (BAT). For a long time, it was considered that BAT is present only in hibernating animals and newborns, conferring them a protection from the cold environment.
V S Kiranmayi, K M Bhargav
doaj   +1 more source

Role of gut microbiota in the postnatal thermoregulation of Brandt’s voles

Cell Reports, 2023
Summary: Homeothermy is crucial for mammals. Postnatal growth is the key period for young offspring to acquire gut microbiota. Although gut microbiota may affect mammal thermogenesis, the impact of developmental regulation of gut microbiota on the ...
Tingbei Bo, Liqiu Tang, Xiaoming Xu, Min Liu, Jing Wen, Jinzhen Lv, Dehua Wang   +6 more
doaj   +1 more source

Effects of Nigella sativa Extracts on the Lipid Profile and Uncoupling Protein-1 Gene Expression in Brown Adipose Tissue of Mice

Advanced Biomedical Research, 2018
Background: Uncoupling protein-1 (UCP-1) is the index protein of the brown adipose tissue (BAT), used in the obesity studies. We evaluated the effects of thymoquinone (TQ), hydroalcoholic, and hexane extracts of Nigella sativa, on the UCP-1 gene ...
Amin Mahmoudi, Keihan Ghatreh Samani, Effat Farrokhi, Esfandiar Heidarian   +3 more
doaj   +1 more source

Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis

Cell Reports, 2020
Summary: Atrial natriuretic peptide (ANP) is a cardiac hormone controlling blood volume and pressure in mammals. It is still unclear whether ANP controls cold-induced thermogenesis in vivo.
Deborah Carper, Marine Coué, Emmani B.M. Nascimento, Valentin Barquissau, Damien Lagarde, Carine Pestourie, Claire Laurens, Justine Vily Petit, Maud Soty, Laurent Monbrun, Marie-Adeline Marques, Yannick Jeanson, Yannis Sainte-Marie, Aline Mairal, Sébastien Déjean, Geneviève Tavernier, Nathalie Viguerie, Virginie Bourlier, Frank Lezoualc’h, Audrey Carrière, Wim H.M. Saris, Arne Astrup, Louis Casteilla, Gilles Mithieux, Wouter van Marken Lichtenbelt, Dominique Langin, Patrick Schrauwen, Cedric Moro   +27 more
doaj   +1 more source

Regulation of autophagy in chick myotube cultures: Effect of uncoupling mitochondrial oxidative phosphorylation

The Journal of Poultry Science, 2023
s: Skeletal muscles have a high demand for ATP, which is met largely through mitochondria oxidative phosphorylation. Autophagy is essential for the maintenance of skeletal muscle mass under catabolic conditions.
Kazuki Nakashima, Aiko Ishida
doaj   +1 more source

Thermogenic Capacity of Human White-Fat: The Actual Picture^†

Proceedings, 2019
AIM: Cold exposure and exercise may increase thermogenic capacity of white adipose tissue (WAT), which could subsequently enhance energy expenditure and body weight loss.
Petros C. Dinas, Argyro Krase, Eleni Nintou, Alexandros Georgakopoulos, Marnie Granzotto, Marinos Metaxas, Eleni Karachaliou, Marco Rossato, Roberto Vettor, Panagiotis Georgoulias, Athanasios Z. Jamurtas, John Koutsikos, Konstantinos Athanasiou, Leonidas G. Ioannou, Paraskevi Gkiata, Andres E. Carrillo, Yiannis Koutedakis, George S. Metsios, Tiago S. Mayor, Sofia Chatziioannou, Andreas D. Flouris   +20 more
doaj   +1 more source