Results 31 to 40 of about 2,019,877 (178)

On the Mechanism of Mitochondrial Uncoupling Protein 1 Function [PDF]

Journal of Biological Chemistry, 2006
Native uncoupling protein 1 (UCP 1) was purified from rat mitochondria by hydroxyapatite chromatography and identified by peptide mass mapping and tandem mass spectrometry. Native and expressed UCP 1 were reconstituted into liposomes, and proton flux through UCP 1 was shown to be fatty acid-dependent and GDP-sensitive.
Eamon P, Breen, Sebastien G, Gouin, Andrew F, Murphy, Lee R, Haines, Angela M, Jackson, Terry W, Pearson, Paul V, Murphy, Richard K, Porter   +7 more
openaire   +2 more sources

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle

Redox Biology, 2023
Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health.
Jinit Masania, Patrick Wijten, Susanne Keipert, Mario Ost, Susanne Klaus, Naila Rabbani, Paul J. Thornalley   +6 more
doaj   +1 more source

Identification of a Functioning Mitochondrial Uncoupling Protein 1 in Thymus [PDF]

Journal of Biological Chemistry, 2005
We present evidence that rat and mouse thymi contain mitochondrial uncoupling protein (UCP 1). Reverse transcriptase-PCR detected RNA transcripts for UCP 1 in whole thymus and in thymocytes. Furthermore, using antibodies to UCP 1 the protein was also detected in mitochondria isolated from whole thymus and thymocytes but not in thymus mitochondria from ...
Audrey M, Carroll, Lee R, Haines, Terry W, Pearson, Padraic G, Fallon, Caitríona M, Walsh, Clare M, Brennan, Eamon P, Breen, Richard K, Porter   +7 more
openaire   +4 more sources

Uncoupling Protein 2, but Not Uncoupling Protein 1, Is Expressed in the Female Mouse Reproductive Tract [PDF]

Journal of Biological Chemistry, 2003
Uncoupling proteins (UCPs) are transporters of the inner mitochondrial membrane. Whereas UCP1 is uniquely present in brown adipose tissue where it uncouples respiration from ATP synthesis and activates respiration and heat production, UCP2 is present in numerous tissues, and its exact function remains to be clarified.
Rousset, Sophie, Alves-Guerra, Marie-Clotilde, Ouadghiri-Bencherif, Salma, Kozak, Leslie, Miroux, Bruno, Richard, Denis, Bouillaud, Frédéric, Ricquier, Daniel, Cassard-Doulcier, Anne-Marie   +8 more
openaire   +2 more sources

Uncoupling protein-1 is not leaky

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
The activity of uncoupling protein-1 (UCP1) is rate-limiting for nonshivering thermogenesis and diet-induced thermogenesis. Characteristically, this activity is inhibited by GDP experimentally and presumably mainly by cytosolic ATP within brown-fat cells.
Shabalina, Irina G., Ost, Mario, Petrovic, Natasa, Vrbacky, Marek, Nedergaard, Jan, Cannon, Barbara   +5 more
openaire   +2 more sources

Synergy of uncoupling proteins (1 and 2) with mitochondrial Ca2+ uptake machinery potentiate mitochondrial uncoupling

Cell Calcium, 2023
Mitochondrial uncoupling proteins UCP1 and UCP2 have a structural homology of app. 60%. They execute their mitochondria uncoupling function through different molecular mechanisms. Non-shivering thermogenesis by UCP1 is mediated through a transmembrane dissipation of the proton motive force to create heat during sympathetic stimulation.
Furkan E. Oflaz, Zhanat Koshenov, Martin Hirtl, Olaf A. Bachkoenig, Wolfgang F. Graier, Benjamin Gottschalk   +5 more
openaire   +2 more sources

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

Cells, 2019
Mitochondrial uncoupling can be defined as a dissociation between mitochondrial membrane potential generation and its use for mitochondria-dependent ATP synthesis.
Stéphane Demine, Patricia Renard, Thierry Arnould   +2 more
doaj   +1 more source

Mitophagy Mediates the Beige to White Transition of Human Primary Subcutaneous Adipocytes Ex Vivo

Pharmaceuticals, 2022
Brown and beige adipocytes have multilocular lipid droplets, express uncoupling protein (UCP) 1, and promote energy expenditure. In rodents, when the stimulus of browning subsides, parkin-dependent mitophagy is activated and dormant beige adipocytes ...
Attila Vámos, Abhirup Shaw, Klára Varga, István Csomós, Gábor Mocsár, Zoltán Balajthy, Cecília Lányi, Zsolt Bacso, Mária Szatmári-Tóth, Endre Kristóf   +9 more
doaj   +1 more source

Metabolic flux analysis of mitochondrial uncoupling in 3T3-L1 adipocytes. [PDF]

PLoS ONE, 2009
BACKGROUND:Increasing energy expenditure at the cellular level offers an attractive option to limit adiposity and improve whole body energy balance. In vivo and in vitro observations have correlated mitochondrial uncoupling protein-1 (UCP1) expression ...
Yaguang Si, Hai Shi, Kyongbum Lee
doaj   +1 more source

The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism

Biochimie, 2017
Uncoupling protein 1 (UCP1) is an integral membrane protein found in the mitochondrial inner membrane of brown adipose tissue, and facilitates the process of non-shivering thermogenesis in mammals.
Paul G. Crichton, Yang Lee, Edmund R. S. Kunji   +2 more
semanticscholar   +1 more source