Results 41 to 50 of about 73,799 (284)

Synergy of uncoupling proteins (1 and 2) with mitochondrial Ca2+ uptake machinery potentiate mitochondrial uncoupling

Cell Calcium, 2023
Mitochondrial uncoupling proteins UCP1 and UCP2 have a structural homology of app. 60%. They execute their mitochondria uncoupling function through different molecular mechanisms. Non-shivering thermogenesis by UCP1 is mediated through a transmembrane dissipation of the proton motive force to create heat during sympathetic stimulation.
Furkan E. Oflaz, Zhanat Koshenov, Martin Hirtl, Olaf A. Bachkoenig, Wolfgang F. Graier, Benjamin Gottschalk   +5 more
openaire   +2 more sources

Mitophagy Mediates the Beige to White Transition of Human Primary Subcutaneous Adipocytes Ex Vivo

Pharmaceuticals, 2022
Brown and beige adipocytes have multilocular lipid droplets, express uncoupling protein (UCP) 1, and promote energy expenditure. In rodents, when the stimulus of browning subsides, parkin-dependent mitophagy is activated and dormant beige adipocytes ...
Attila Vámos, Abhirup Shaw, Klára Varga, István Csomós, Gábor Mocsár, Zoltán Balajthy, Cecília Lányi, Zsolt Bacso, Mária Szatmári-Tóth, Endre Kristóf   +9 more
doaj   +1 more source

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

Cells, 2019
Mitochondrial uncoupling can be defined as a dissociation between mitochondrial membrane potential generation and its use for mitochondria-dependent ATP synthesis.
Stéphane Demine, Patricia Renard, Thierry Arnould   +2 more
doaj   +1 more source

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice [PDF]

, 2011
Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease).
Burgess, Laura A, Howlett, David R, Meakin, PJ, Vaanholt, Lobke M, Hamilton, DL, Vaanholt, Lobke M., Judy Latcham, Burgess, Laura A., Alison D. McNeilly, Burgess, LA, Michael L.J. Ashford, D. Lee Hamilton, Lobke M. Vaanholt, Kirsten A. Bannon, Ashford, MLJ, David R. Howlett, Speakman, John R, McNeilly, Alison D, Alex J. Harper, John R. Speakman, Ashford, Michael L J, Speakman, John R., Gallagher, J, Hamilton, David Lee, McNeilly, Alison D.; id_orcid, Hussain, Ishrut, Hamilton, D. Lee, Meakin, Paul J.; id_orcid, Latcham, J, Harper, Alex J, Bannon, KA, McNeilly, AD, Jennifer Gallagher, Latcham, Judy, Howlett, DR, Ashford, Michael L. J.; id_orcid, Vaanholt, LM, Hussain, I, Gallagher, Jennifer, Harper, Alex J., Bannon, Kirsten A., Paul J. Meakin, Bannon, Kirsten A, Ishrut Hussain, Harper, AJ, Meakin, Paul J, Laura A. Burgess, Howlett, David R., Speakman, JR   +48 more
core   +1 more source

Metabolic flux analysis of mitochondrial uncoupling in 3T3-L1 adipocytes. [PDF]

PLoS ONE, 2009
BACKGROUND:Increasing energy expenditure at the cellular level offers an attractive option to limit adiposity and improve whole body energy balance. In vivo and in vitro observations have correlated mitochondrial uncoupling protein-1 (UCP1) expression ...
Yaguang Si, Hai Shi, Kyongbum Lee
doaj   +1 more source

Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia [PDF]

, 2010
AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic beta-cell function remains unclear.
Withers, DJ, Ashford, ML, Smith, Mark A., Al-Qassab, H, Piipari, K, Piipari, Kaisa, Al-Qassab, Hind, Smith, Mark A, Viollet, Benoit, Ashford, Michael Lj, Viollet, B, Beall, Craig, Smith, MA, Withers, Dominic J, Parker, N, Carling, David, Parker, Nadeene, Withers, Dominic J., Ashford, Michael L. J.; id_orcid, Beall, C, Carling, D   +20 more
core   +1 more source

Phosphorus Supplementation Mitigates Perivascular Adipose Inflammation–Induced Cardiovascular Consequences in Early Metabolic Impairment

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The complexity of the interaction between metabolic dysfunction and cardiovascular complications has long been recognized to extend beyond simple perturbations of blood glucose levels.
Haneen S. Dwaib, Ghina Ajouz, Ibrahim AlZaim, Rim Rafeh, Ali Mroueh, Nahed Mougharbil, Marie‐Elizabeth Ragi, Marwan Refaat, Omar Obeid, Ahmed F. El‐Yazbi   +9 more
doaj   +1 more source

Transcriptional regulation of the uncoupling protein-1 gene

Biochimie, 2017
Regulated transcription of the uncoupling protein-1 (UCP1) gene, and subsequent UCP1 protein synthesis, is a hallmark of the acquisition of the differentiated, thermogenically competent status of brown and beige/brite adipocytes, as well as of the responsiveness of brown and beige/brite adipocytes to adaptive regulation of thermogenic activity.
Villarroya F, Peyrou M, Giralt M
openaire   +4 more sources

Skeletal muscle uncoupling protein 3 (UCP3): mitochondrial uncoupling protein in search of a function [PDF]

, 2002
Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Human Biology, Maastricht University, The Netherlands. p.schrauwen@hb.unimaas.nl The uncoupling protein 1 homologue, uncoupling protein 3, is able to uncouple adenosine ...
Schrauwen, P.
core   +1 more source

Uncoupling Protein 2 Increases Blood Pressure in DJ‐1 Knockout Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The redox‐sensitive chaperone DJ‐1 and uncoupling protein 2 are protective against mitochondrial oxidative stress. We previously reported that renal‐selective depletion and germline deletion of DJ‐1 increases blood pressure in mice. This study
Carmen De Miguel, William C. Hamrick, Randee Sedaka, Sudha Jagarlamudi, Laureano D. Asico, Pedro A. Jose, Santiago Cuevas   +6 more
doaj   +1 more source