Results 41 to 50 of about 69,972 (249)

Mitochondrial uncoupling protein 1 expression in thymocytes

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2008
Using an antibody specific and selective to mitochondrial uncoupling protein 1 (UCP1) peptide, this study confirms the observation that UCP 1 is present in thymocytes isolated from UCP 1 wild-type, but not UCP 1 knock-out mice. UCP 1 is also shown to be present in thymocytes isolated from rat.
Adams, Alison E., Carroll, Audrey M., Fallon, Padraic G., Porter, Richard K.   +3 more
openaire   +4 more sources

Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation

Journal of Obesity & Metabolic Syndrome, 2018
Background : Uncoupling protein 1 (UCP1) plays an important role in increasing energy expenditure; thus, it is being considered as a new target for preventing obesity and metabolic complications.
Hyunjung Choi, Chu-Sook Kim, Rina Yu
doaj   +1 more source

Myoglobin‐mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans

Clinical and Translational Medicine, 2022
Background Recruitment and activation of brown adipose tissue (BAT) results in increased energy expenditure (EE) via thermogenesis and represents an intriguing therapeutic approach to combat obesity and treat associated diseases.
Lisa Christen, Helen Broghammer, Inka Rapöhn, Kevin Möhlis, Christian Strehlau, Aleix Ribas‐Latre, Claudia Gebhardt, Lisa Roth, Kerstin Krause, Kathrin Landgraf, Antje Körner, Kerstin Rohde‐Zimmermann, Anne Hoffmann, Nora Klöting, Adhideb Ghosh, Wenfei Sun, Hua Dong, Christian Wolfrum, Tienush Rassaf, Ulrike B. Hendgen‐Cotta, Michael Stumvoll, Matthias Blüher, John T. Heiker, Juliane Weiner   +23 more
doaj   +1 more source

Phosphorus Supplementation Mitigates Perivascular Adipose Inflammation–Induced Cardiovascular Consequences in Early Metabolic Impairment

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The complexity of the interaction between metabolic dysfunction and cardiovascular complications has long been recognized to extend beyond simple perturbations of blood glucose levels.
Haneen S. Dwaib, Ghina Ajouz, Ibrahim AlZaim, Rim Rafeh, Ali Mroueh, Nahed Mougharbil, Marie‐Elizabeth Ragi, Marwan Refaat, Omar Obeid, Ahmed F. El‐Yazbi   +9 more
doaj   +1 more source

Mitochondrial proton leak and the uncoupling protein 1 homologues

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2001
Mitochondrial proton leak is the largest single contributor to the standard metabolic rate (SMR) of a rat, accounting for about 20% of SMR. Yet the mechanisms by which proton leak occurs are incompletely understood. The available evidence suggests that both phospholipids and proteins in the mitochondrial inner membrane are important determinants of ...
Stuart, J.A, Cadenas, S, Jekabsons, M.B, Roussel, D, Brand, M.D   +4 more
openaire   +2 more sources

Possible involvement of uncoupling protein 1 in appetite control by leptin [PDF]

Experimental Biology and Medicine, 2011
Leptin reduces body fat by decreasing food intake and increasing energy expenditure. Uncoupling protein (UCP) 1, a key molecule for brown adipose tissue (BAT) thermogenesis, was reported to contribute to the stimulatory effect of leptin on energy expenditure.
Okamatsu-Ogura, Yuko, Nio-Kobayashi, Junko, Iwanaga, Toshihiko, Terao, Akira, Kimura, Kazuhiro, Saito, Masayuki   +5 more
openaire   +3 more sources

Test systems to study the structure and function of uncoupling protein 1: a critical overview

Frontiers in Endocrinology, 2011
The discovery of active brown adipose tissue (BAT) in healthy adult humans has renewed interest in the biology of this organ. BAT is capable of distributing nutrient energy in the form of heat allowing small mammals to efficiently defend their body ...
Verena eHirschberg, Tobias eFromme, Martin eKlingenspor   +2 more
doaj   +1 more source

The Therapeutic Potential of Brown Adipocytes in Humans

Frontiers in Endocrinology, 2015
Obesity and its metabolic consequences represent a significant clinical problem. From a thermodynamic standpoint, obesity results from a discord in energy intake and expenditure.
Craig ePorter, Craig ePorter, Maria eChondronikola, Maria eChondronikola, Labros S Sidossis, Labros S Sidossis, Labros S Sidossis   +6 more
doaj   +1 more source

Identification of serine phosphorylation in mitochondrial uncoupling protein 1

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2008
Native uncoupling protein 1 was purified from rat brown adipose tissue of cold-acclimated rats and rats kept at room temperature, in the presence of phosphatase inhibitors. The purified protein from cold-acclimated animals was digested with trypsin and immobilized metal affinity chromatography was used to select for phosphopeptides.
Carroll, Audrey M., Porter, Richard K., Morrice, Nick A.   +2 more
openaire   +2 more sources

The complementary and divergent roles of uncoupling proteins 1 and 3 in thermoregulation [PDF]

The Journal of Physiology, 2016
Key points Both uncoupling protein 1 (UCP1) and UCP3 are important for mammalian thermoregulation. UCP1 and UCP3 in brown adipose tissue mediate early and late phases of sympathomimetic thermogenesis, respectively. Lipopolysaccharide thermogenesis requires skeletal muscle UCP3 but not UCP1. Acute noradrenaline‐induced hyperthermia requires UCP1 but not
Riley, Christopher L., Dao, Christine, Kenaston, M. Alexander, Muto, Luigina, Kohno, Shohei, Nowinski, Sara M., Solmonson, Ashley D., Pfeiffer, Matthew, Sack, Michael N., Lu, Zhongping, FIERMONTE, Giuseppe, Sprague, Jon E., Mills, Edward M.   +12 more
openaire   +3 more sources