Results 31 to 40 of about 73,799 (284)

Substrate fluxes in brown adipocytes upon adrenergic stimulation and uncoupling protein 1 ablation [PDF]

Life Science Alliance, 2018
Quantification of substrate fluxes in brown adipocytes clarifies contributors to extracellular acidification, identifies a futile cycle of lipolysis and re-esterification, and suggests a role for glycogen during activation.
Sabine Schweizer, Josef Oeckl, Martin Klingenspor, Tobias Fromme   +3 more
doaj   +2 more sources

Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study [PDF]

BMC Medical Genetics, 2018
Background Obesity is one of the main causes of morbidity and mortality worldwide. More than 120 genes have been shown to be associated with obesity related phenotypes.
Shahanas Chathoth, Mona H. Ismail, Chittibabu Vatte, Cyril Cyrus, Zhara Al Ali, Khandaker Ahtesham Ahmed, Sadananda Acharya, Aisha Mohammed Al Barqi, Amein Al Ali   +8 more
doaj   +2 more sources

Proton conductance by human uncoupling protein 1 is inhibited by purine and pyrimidine nucleotides [PDF]

The EMBO Journal
Uncoupling protein 1 (UCP1, SLC25A7) is responsible for the thermogenic properties of brown adipose tissue. Upon fatty acid activation, UCP1 facilitates proton leakage, dissipating the mitochondrial proton motive force to release energy as heat.
Scott A Jones, Alice P Sowton, Denis Lacabanne, Martin S King, Shane M Palmer, Thomas Zögg, Els Pardon, Jan Steyaert, Jonathan J Ruprecht, Edmund R S Kunji   +9 more
doaj   +2 more sources

In silico identification of lipid-binding α helices of uncoupling protein 1. [PDF]

Biomed Rep, 2018
Uncoupling protein 1 (UCP1) located at the mitochondrial inner membrane serves an important role in adaptive non-shivering thermogenesis. Previous data has demonstrated that membrane lipids regulate the biological functions of membrane proteins. However, how mitochondrial lipids interact with UCP1 still remains elusive.
Jing Y, Niu Y, Liu C, Zen K, Li D.
europepmc   +4 more sources

Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis [PDF]

Trends in Biochemical Sciences
In mitochondria, the oxidation of nutrients is coupled to ATP synthesis by the generation of a protonmotive force across the mitochondrial inner membrane. In mammalian brown adipose tissue (BAT), uncoupling protein 1 (UCP1, SLC25A7), a member of the SLC25 mitochondrial carrier family, dissipates the protonmotive force by facilitating the return of ...
Scott A. Jones, Jonathan J. Ruprecht, Paul G. Crichton, Edmund R.S. Kunji   +3 more
openaire   +5 more sources

Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1) [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2019
Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering thermogenesis. Mitochondrial uncoupling protein 1 (UCP1), specific for these tissues, is the key factor for heat production.
Petr, Ježek, Martin, Jabůrek, Richard K, Porter   +2 more
openaire   +2 more sources

Uncoupling Protein 2, but Not Uncoupling Protein 1, Is Expressed in the Female Mouse Reproductive Tract [PDF]

Journal of Biological Chemistry, 2003
Uncoupling proteins (UCPs) are transporters of the inner mitochondrial membrane. Whereas UCP1 is uniquely present in brown adipose tissue where it uncouples respiration from ATP synthesis and activates respiration and heat production, UCP2 is present in numerous tissues, and its exact function remains to be clarified.
Rousset, Sophie, Alves-Guerra, Marie-Clotilde, Ouadghiri-Bencherif, Salma, Kozak, Leslie, Miroux, Bruno, Richard, Denis, Bouillaud, Frédéric, Ricquier, Daniel, Cassard-Doulcier, Anne-Marie   +8 more
openaire   +2 more sources

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle

Redox Biology, 2023
Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health.
Jinit Masania, Patrick Wijten, Susanne Keipert, Mario Ost, Susanne Klaus, Naila Rabbani, Paul J. Thornalley   +6 more
doaj   +1 more source

On the Mechanism of Mitochondrial Uncoupling Protein 1 Function [PDF]

Journal of Biological Chemistry, 2006
Native uncoupling protein 1 (UCP 1) was purified from rat mitochondria by hydroxyapatite chromatography and identified by peptide mass mapping and tandem mass spectrometry. Native and expressed UCP 1 were reconstituted into liposomes, and proton flux through UCP 1 was shown to be fatty acid-dependent and GDP-sensitive.
Eamon P, Breen, Sebastien G, Gouin, Andrew F, Murphy, Lee R, Haines, Angela M, Jackson, Terry W, Pearson, Paul V, Murphy, Richard K, Porter   +7 more
openaire   +2 more sources

Uncoupling protein-1 is not leaky

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
The activity of uncoupling protein-1 (UCP1) is rate-limiting for nonshivering thermogenesis and diet-induced thermogenesis. Characteristically, this activity is inhibited by GDP experimentally and presumably mainly by cytosolic ATP within brown-fat cells.
Shabalina, Irina G., Ost, Mario, Petrovic, Natasa, Vrbacky, Marek, Nedergaard, Jan, Cannon, Barbara   +5 more
openaire   +2 more sources