Results 31 to 40 of about 69,972 (249)

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle

Redox Biology, 2023
Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health.
Jinit Masania, Patrick Wijten, Susanne Keipert, Mario Ost, Susanne Klaus, Naila Rabbani, Paul J. Thornalley   +6 more
doaj   +1 more source

Identification of a Functioning Mitochondrial Uncoupling Protein 1 in Thymus [PDF]

Journal of Biological Chemistry, 2005
We present evidence that rat and mouse thymi contain mitochondrial uncoupling protein (UCP 1). Reverse transcriptase-PCR detected RNA transcripts for UCP 1 in whole thymus and in thymocytes. Furthermore, using antibodies to UCP 1 the protein was also detected in mitochondria isolated from whole thymus and thymocytes but not in thymus mitochondria from ...
Audrey M, Carroll, Lee R, Haines, Terry W, Pearson, Padraic G, Fallon, Caitríona M, Walsh, Clare M, Brennan, Eamon P, Breen, Richard K, Porter   +7 more
openaire   +4 more sources

Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity

Molecular Metabolism, 2018
Objective: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition.
Tobias Fromme, Karin Kleigrewe, Andreas Dunkel, Angelika Retzler, Yongguo Li, Stefanie Maurer, Natascha Fischer, Rolf Diezko, Timo Kanzleiter, Verena Hirschberg, Thomas Hofmann, Martin Klingenspor   +11 more
doaj   +1 more source

Uncoupling protein-1 is not leaky

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
The activity of uncoupling protein-1 (UCP1) is rate-limiting for nonshivering thermogenesis and diet-induced thermogenesis. Characteristically, this activity is inhibited by GDP experimentally and presumably mainly by cytosolic ATP within brown-fat cells.
Shabalina, Irina G., Ost, Mario, Petrovic, Natasa, Vrbacky, Marek, Nedergaard, Jan, Cannon, Barbara   +5 more
openaire   +2 more sources

Synergy of uncoupling proteins (1 and 2) with mitochondrial Ca2+ uptake machinery potentiate mitochondrial uncoupling

Cell Calcium, 2023
Mitochondrial uncoupling proteins UCP1 and UCP2 have a structural homology of app. 60%. They execute their mitochondria uncoupling function through different molecular mechanisms. Non-shivering thermogenesis by UCP1 is mediated through a transmembrane dissipation of the proton motive force to create heat during sympathetic stimulation.
Furkan E. Oflaz, Zhanat Koshenov, Martin Hirtl, Olaf A. Bachkoenig, Wolfgang F. Graier, Benjamin Gottschalk   +5 more
openaire   +2 more sources

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

Cells, 2019
Mitochondrial uncoupling can be defined as a dissociation between mitochondrial membrane potential generation and its use for mitochondria-dependent ATP synthesis.
Stéphane Demine, Patricia Renard, Thierry Arnould   +2 more
doaj   +1 more source

Mitophagy Mediates the Beige to White Transition of Human Primary Subcutaneous Adipocytes Ex Vivo

Pharmaceuticals, 2022
Brown and beige adipocytes have multilocular lipid droplets, express uncoupling protein (UCP) 1, and promote energy expenditure. In rodents, when the stimulus of browning subsides, parkin-dependent mitophagy is activated and dormant beige adipocytes ...
Attila Vámos, Abhirup Shaw, Klára Varga, István Csomós, Gábor Mocsár, Zoltán Balajthy, Cecília Lányi, Zsolt Bacso, Mária Szatmári-Tóth, Endre Kristóf   +9 more
doaj   +1 more source

Metabolic flux analysis of mitochondrial uncoupling in 3T3-L1 adipocytes. [PDF]

PLoS ONE, 2009
BACKGROUND:Increasing energy expenditure at the cellular level offers an attractive option to limit adiposity and improve whole body energy balance. In vivo and in vitro observations have correlated mitochondrial uncoupling protein-1 (UCP1) expression ...
Yaguang Si, Hai Shi, Kyongbum Lee
doaj   +1 more source

Supplementary prenatal copper increases plasma triiodothyronine and brown adipose tissue uncoupling protein-1 gene expression but depresses thermogenesis in newborn lambs [PDF]

Asian-Australasian Journal of Animal Sciences, 2020
Objective We tested the hypothesis that increasing dietary copper (Cu) to gravid ewes would enhance brown adipose tissue (BAT) thermogenesis in their offspring. Methods Twin-bearing ewes were assigned on d 70 of gestation to diets containing 3, 10, or 20
Stephen B. Smith, Craig R. Sweatt, Gordon E. Carstens   +2 more
doaj   +1 more source

Uncoupling Protein 2 Increases Blood Pressure in DJ‐1 Knockout Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The redox‐sensitive chaperone DJ‐1 and uncoupling protein 2 are protective against mitochondrial oxidative stress. We previously reported that renal‐selective depletion and germline deletion of DJ‐1 increases blood pressure in mice. This study
Carmen De Miguel, William C. Hamrick, Randee Sedaka, Sudha Jagarlamudi, Laureano D. Asico, Pedro A. Jose, Santiago Cuevas   +6 more
doaj   +1 more source