Identification of serine phosphorylation in mitochondrial uncoupling protein 1
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2008 Native uncoupling protein 1 was purified from rat brown adipose tissue of cold-acclimated rats and rats kept at room temperature, in the presence of phosphatase inhibitors. The purified protein from cold-acclimated animals was digested with trypsin and immobilized metal affinity chromatography was used to select for phosphopeptides.
Carroll, Audrey M. +2 more
openaire +3 more sources
Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura +6 more
doaj +5 more sources
Uncoupling Protein 1 Promotes Nile Tilapia Resistance to Acute Cold Stress by Regulating Liver Metabolism [PDF]
MetabolitesBackground: Low temperature stress is a major environmental challenge affecting the growth, metabolism, and survival of many aquaculture species, including Nile tilapia (Oreochromis niloticus).
Meiqing Li +8 more
doaj +2 more sources
Relationship between uncoupling protein 1 (UCP1) levels and psoriasis. [PDF]
Turk J Med SciPsoriasis is a common chronic autoimmune skin disease. Comorbidities increase the mortality risk of the disease. The aim of this study was to investigate the changes in uncoupling protein 1 (UCP1) level in psoriasis patients and evaluate its possible role in the pathogenesis of the disease, focusing on disease severity (Psoriasis Area and Severity ...
Akyürek F +2 more
europepmc +3 more sources
Impact of the Uncoupling Protein 1 on Cardiovascular Risk in Patients with Rheumatoid Arthritis [PDF]
Cells, 2021 Adiposity is strongly associated with cardiovascular (CV) morbidity. Uncoupling protein 1 (UCP1) increases energy expenditure in adipocytes and may counteract adiposity.
Lovisa I. Lyngfelt +9 more
doaj +2 more sources
Identification of a Functioning Mitochondrial Uncoupling Protein 1 in Thymus [PDF]
Journal of Biological Chemistry, 2005 We present evidence that rat and mouse thymi contain mitochondrial uncoupling protein (UCP 1). Reverse transcriptase-PCR detected RNA transcripts for UCP 1 in whole thymus and in thymocytes. Furthermore, using antibodies to UCP 1 the protein was also detected in mitochondria isolated from whole thymus and thymocytes but not in thymus mitochondria from ...
Audrey M, Carroll +7 more
openaire +5 more sources
FEBS Letters, 2002 Earlier we reported a 14‐fold increase of glycogen in the brown adipose tissue (BAT) in rats when the animals were placed back from cold to neutral temperature. To elucidate the mechanism, here we compared the level of glucose transporter 4 (GLUT4) protein, uncoupling protein (UCP) 1 and UCP3 mRNA and protein expressions in the BAT under the same ...
Jakus, P.B +3 more
openaire +3 more sources
Hypoxia-inducible factor-1α-deficient adipose-tissue macrophages produce the heat to mediate lipolysis of white adipose tissue through uncoupling protein-1 [PDF]
Laboratory Animal ResearchBackground Uncoupling protein 1 (UCP1) is a proton uncoupler located across the mitochondrial membrane generally involved in thermogenesis of brown adipose tissues.
Gi-Sue Kang +10 more
doaj +2 more sources
Uncoupling protein-1 deficiency promotes brown adipose tissue inflammation and ER stress. [PDF]
PLoS ONE, 2018 Inflammation and endoplasmic reticulum (ER) stress are hallmarks of metabolic syndrome. While these metabolic derangements have been well-investigated in white adipose tissue, their existence and etiology in brown adipose tissue (BAT) are poorly ...
Laura M Bond +2 more
doaj +2 more sources
Cell-free production and characterisation of human uncoupling protein 1–3
Biochemistry and Biophysics Reports, 2017 The uncoupling proteins (UCPs) leak protons across the inner mitochondrial membrane, thus uncoupling the proton gradient from ATP synthesis. The main known physiological role for this is heat generation by UCP1 in brown adipose tissue.
Etienne Rebuffet +3 more
doaj +3 more sources