Cell-free production and characterisation of human uncoupling protein 1–3
Biochemistry and Biophysics Reports, 2017 The uncoupling proteins (UCPs) leak protons across the inner mitochondrial membrane, thus uncoupling the proton gradient from ATP synthesis. The main known physiological role for this is heat generation by UCP1 in brown adipose tissue.
Etienne Rebuffet +3 more
doaj +3 more sources
Uncoupling protein-1 deficiency promotes brown adipose tissue inflammation and ER stress. [PDF]
PLoS ONE, 2018 Inflammation and endoplasmic reticulum (ER) stress are hallmarks of metabolic syndrome. While these metabolic derangements have been well-investigated in white adipose tissue, their existence and etiology in brown adipose tissue (BAT) are poorly ...
Laura M Bond +2 more
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Substrate fluxes in brown adipocytes upon adrenergic stimulation and uncoupling protein 1 ablation [PDF]
Life Science Alliance, 2018 Quantification of substrate fluxes in brown adipocytes clarifies contributors to extracellular acidification, identifies a futile cycle of lipolysis and re-esterification, and suggests a role for glycogen during activation.
Sabine Schweizer +3 more
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Proton conductance by human uncoupling protein 1 is inhibited by purine and pyrimidine nucleotides [PDF]
The EMBO JournalUncoupling protein 1 (UCP1, SLC25A7) is responsible for the thermogenic properties of brown adipose tissue. Upon fatty acid activation, UCP1 facilitates proton leakage, dissipating the mitochondrial proton motive force to release energy as heat.
Scott A Jones +9 more
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Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study [PDF]
BMC Medical Genetics, 2018 Background Obesity is one of the main causes of morbidity and mortality worldwide. More than 120 genes have been shown to be associated with obesity related phenotypes.
Shahanas Chathoth +8 more
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Uncoupling Protein 1 Does Not Produce Heat without Activation. [PDF]
Int J Mol Sci, 2022 Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat production in classical brown fat and the newly identified beige or brite fat. Thermogenesis inevitably comes at a high energetic cost and brown fat, ultimately, is an energy-wasting organ. A constrained strategy that minimizes brown fat activity unless obligate will
Li Y, Fromme T.
europepmc +4 more sources
Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1) [PDF]
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2019 Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering thermogenesis. Mitochondrial uncoupling protein 1 (UCP1), specific for these tissues, is the key factor for heat production.
Petr, Ježek +2 more
openaire +2 more sources
Relationship between uncoupling protein 1 (UCP1) levels and psoriasis. [PDF]
Turk J Med SciBackground/aim: Psoriasis is an autoimmune, chronic and common skin disease. Comorbidities also increase the mortality risk of the disease. The aim of this study is to investigate the changes in UCP1 levels in psoriasis patients and to evaluate their possible role in the pathogenesis of the disease, focusing on disease severity (Psoriasis Area and ...
Akyürek F +2 more
europepmc +3 more sources
Uncoupling Protein 2, but Not Uncoupling Protein 1, Is Expressed in the Female Mouse Reproductive Tract [PDF]
Journal of Biological Chemistry, 2003 Uncoupling proteins (UCPs) are transporters of the inner mitochondrial membrane. Whereas UCP1 is uniquely present in brown adipose tissue where it uncouples respiration from ATP synthesis and activates respiration and heat production, UCP2 is present in numerous tissues, and its exact function remains to be clarified.
Rousset, Sophie +8 more
openaire +2 more sources
On the Mechanism of Mitochondrial Uncoupling Protein 1 Function [PDF]
Journal of Biological Chemistry, 2006 Native uncoupling protein 1 (UCP 1) was purified from rat mitochondria by hydroxyapatite chromatography and identified by peptide mass mapping and tandem mass spectrometry. Native and expressed UCP 1 were reconstituted into liposomes, and proton flux through UCP 1 was shown to be fatty acid-dependent and GDP-sensitive.
Eamon P, Breen +7 more
openaire +2 more sources