FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1
Cell Reports, 2015 Fibroblast growth factor 21 (FGF21)-mediated weight loss and improvements in glucose metabolism correlate with increased uncoupling protein 1 (Ucp1) levels in adipose tissues, suggesting that UCP1-dependent thermogenesis may drive FGF21 action.
Michelle M. Kwon +4 more
doaj +4 more sources
Uncoupling protein 1 inhibits mitochondrial reactive oxygen species generation and alleviates acute kidney injury [PDF]
EBioMedicine, 2019 Background: Uncoupling protein 1 (UCP1) is predominantly found in brown adipose tissue mitochondria, and mediates energy dissipation to generate heat rather than ATP via functional mitochondrial uncoupling.
Ping Jia +5 more
doaj +4 more sources
CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression [PDF]
Antioxidants, 2022 Coenzyme Q (CoQ, aka ubiquinone) is a key component of the mitochondrial electron transport chain (ETC) and membrane-incorporated antioxidant. CoQ10 deficiencies encompass a heterogeneous spectrum of clinical phenotypes and can be caused by hereditary ...
Ching-Fang Chang +6 more
doaj +2 more sources
Uncoupling protein 1 (UCP1) of brown adipocyte, the only uncoupler: historical perspective [PDF]
Frontiers in Endocrinology, 2011 Uncoupling protein 1 - UCP1, is a unique mitochondrial membranous protein devoted to adaptive thermogenesis, a specialized function operated by the highly specialized oxidative brown adipocytes.
Daniel eRicquier
doaj +4 more sources
Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis [PDF]
Molecular Metabolism, 2022 Objective: Uncoupling protein 1 (UCP1) catalyses mitochondrial proton leak in brown adipose tissue to facilitate nutrient oxidation for heat production, and may combat metabolic disease if activated in humans.
Riccardo Cavalieri +7 more
doaj +2 more sources
Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity
Molecular Metabolism, 2018 Objective: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition.
Tobias Fromme +11 more
doaj +3 more sources
Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus [PDF]
Journal of Lipid Research, 1998 Uncoupling protein-1 (UCP-1) activity in brown adipose tissue increases thermogenesis, contributes to facultative energy expenditure in humans, and has been implicated in the pathogenesis of rodent obesity.
Harald Esterbauer +6 more
doaj +3 more sources
Mitochondrial uncoupling protein 1 expression in thymocytes
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2008 Using an antibody specific and selective to mitochondrial uncoupling protein 1 (UCP1) peptide, this study confirms the observation that UCP 1 is present in thymocytes isolated from UCP 1 wild-type, but not UCP 1 knock-out mice. UCP 1 is also shown to be present in thymocytes isolated from rat.
Adams, Alison E. +3 more
core +6 more sources
Uncoupling Protein 1 Does Not Produce Heat without Activation. [PDF]
Int J Mol Sci, 2022 Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat production in classical brown fat and the newly identified beige or brite fat. Thermogenesis inevitably comes at a high energetic cost and brown fat, ultimately, is an energy-wasting organ. A constrained strategy that minimizes brown fat activity unless obligate will
Li Y, Fromme T.
europepmc +4 more sources
Mitochondrial proton leak and the uncoupling protein 1 homologues
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2001 Mitochondrial proton leak is the largest single contributor to the standard metabolic rate (SMR) of a rat, accounting for about 20% of SMR. Yet the mechanisms by which proton leak occurs are incompletely understood. The available evidence suggests that both phospholipids and proteins in the mitochondrial inner membrane are important determinants of ...
Stuart, J.A +4 more
openaire +3 more sources