Uncoupling protein 1 inhibits mitochondrial reactive oxygen species generation and alleviates acute kidney injury [PDF]
EBioMedicine, 2019 Background: Uncoupling protein 1 (UCP1) is predominantly found in brown adipose tissue mitochondria, and mediates energy dissipation to generate heat rather than ATP via functional mitochondrial uncoupling.
Ping Jia +5 more
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CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression [PDF]
Antioxidants, 2022 Coenzyme Q (CoQ, aka ubiquinone) is a key component of the mitochondrial electron transport chain (ETC) and membrane-incorporated antioxidant. CoQ10 deficiencies encompass a heterogeneous spectrum of clinical phenotypes and can be caused by hereditary ...
Ching-Fang Chang +6 more
doaj +2 more sources
Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis [PDF]
Molecular Metabolism, 2022 Objective: Uncoupling protein 1 (UCP1) catalyses mitochondrial proton leak in brown adipose tissue to facilitate nutrient oxidation for heat production, and may combat metabolic disease if activated in humans.
Riccardo Cavalieri +7 more
doaj +2 more sources
Uncoupling protein 1 (UCP1) of brown adipocyte, the only uncoupler: historical perspective [PDF]
Frontiers in Endocrinology, 2011 Uncoupling protein 1 - UCP1, is a unique mitochondrial membranous protein devoted to adaptive thermogenesis, a specialized function operated by the highly specialized oxidative brown adipocytes.
Daniel eRicquier
doaj +4 more sources
Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus [PDF]
Journal of Lipid Research, 1998 Uncoupling protein-1 (UCP-1) activity in brown adipose tissue increases thermogenesis, contributes to facultative energy expenditure in humans, and has been implicated in the pathogenesis of rodent obesity.
Harald Esterbauer +6 more
doaj +3 more sources
Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura +6 more
doaj +5 more sources
Uncoupling Protein 1 Promotes Nile Tilapia Resistance to Acute Cold Stress by Regulating Liver Metabolism [PDF]
MetabolitesBackground: Low temperature stress is a major environmental challenge affecting the growth, metabolism, and survival of many aquaculture species, including Nile tilapia (Oreochromis niloticus).
Meiqing Li +8 more
doaj +2 more sources
Impact of the Uncoupling Protein 1 on Cardiovascular Risk in Patients with Rheumatoid Arthritis [PDF]
Cells, 2021 Adiposity is strongly associated with cardiovascular (CV) morbidity. Uncoupling protein 1 (UCP1) increases energy expenditure in adipocytes and may counteract adiposity.
Lovisa I. Lyngfelt +9 more
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Hypoxia-inducible factor-1α-deficient adipose-tissue macrophages produce the heat to mediate lipolysis of white adipose tissue through uncoupling protein-1 [PDF]
Laboratory Animal ResearchBackground Uncoupling protein 1 (UCP1) is a proton uncoupler located across the mitochondrial membrane generally involved in thermogenesis of brown adipose tissues.
Gi-Sue Kang +10 more
doaj +2 more sources
FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1
Cell Reports, 2015 Fibroblast growth factor 21 (FGF21)-mediated weight loss and improvements in glucose metabolism correlate with increased uncoupling protein 1 (Ucp1) levels in adipose tissues, suggesting that UCP1-dependent thermogenesis may drive FGF21 action.
Michelle M. Kwon +4 more
doaj +3 more sources