Results 51 to 60 of about 73,799 (284)

Supplementary prenatal copper increases plasma triiodothyronine and brown adipose tissue uncoupling protein-1 gene expression but depresses thermogenesis in newborn lambs [PDF]

Asian-Australasian Journal of Animal Sciences, 2020
Objective We tested the hypothesis that increasing dietary copper (Cu) to gravid ewes would enhance brown adipose tissue (BAT) thermogenesis in their offspring. Methods Twin-bearing ewes were assigned on d 70 of gestation to diets containing 3, 10, or 20
Stephen B. Smith, Craig R. Sweatt, Gordon E. Carstens   +2 more
doaj   +1 more source

RIP140 represses the “Brown-in-White” adipocyte program including a futile cycle of triacyclglycerol breakdown and synthesis [PDF]

, 2014
Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues. We investigated the role of RIP140 in conditionally immortal preadipocyte cell lines prepared from white or brown fat depots.
Edward Curry, Curry, Edward, Myrsini Kaforou, Cinti, S, Cinti, Saverio, Saverio Cinti, Lemonia Chatzeli, Parker, MG, Kiskinis, E, Kiskinis, Evangelos, Kaforou, M, Frontini, A, Chatzeli, Lemonia, Montana, G, Chatzeli, L, Curry, E, Kaforou, Myrsini, Evangelos Kiskinis, Montana, Giovanni, Christian, Mark, Giovanni Montana, Frontini, Andrea, Mark Christian, Parker, Malcolm G., Christian, M, Malcolm G. Parker   +25 more
core   +1 more source

Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation

Journal of Obesity & Metabolic Syndrome, 2018
Background : Uncoupling protein 1 (UCP1) plays an important role in increasing energy expenditure; thus, it is being considered as a new target for preventing obesity and metabolic complications.
Hyunjung Choi, Chu-Sook Kim, Rina Yu
doaj   +1 more source

Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells

, 2005
Decreased uncoupling protein (UCP)3 is associated with insulin resistance in muscle of pre-diabetic and diabetic individuals, but the function of UCP3 remains unclear.
Gerrits, Martin F., Wheeler, Michael B., Harper, Mary-Ellen, MacLellan, J. Darcy, Gowing, Adrienne, Smith, Peter J.S.   +5 more
core   +1 more source

Test systems to study the structure and function of uncoupling protein 1: a critical overview

Frontiers in Endocrinology, 2011
The discovery of active brown adipose tissue (BAT) in healthy adult humans has renewed interest in the biology of this organ. BAT is capable of distributing nutrient energy in the form of heat allowing small mammals to efficiently defend their body ...
Verena eHirschberg, Tobias eFromme, Martin eKlingenspor   +2 more
doaj   +1 more source

Myoglobin‐mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans

Clinical and Translational Medicine, 2022
Background Recruitment and activation of brown adipose tissue (BAT) results in increased energy expenditure (EE) via thermogenesis and represents an intriguing therapeutic approach to combat obesity and treat associated diseases.
Lisa Christen, Helen Broghammer, Inka Rapöhn, Kevin Möhlis, Christian Strehlau, Aleix Ribas‐Latre, Claudia Gebhardt, Lisa Roth, Kerstin Krause, Kathrin Landgraf, Antje Körner, Kerstin Rohde‐Zimmermann, Anne Hoffmann, Nora Klöting, Adhideb Ghosh, Wenfei Sun, Hua Dong, Christian Wolfrum, Tienush Rassaf, Ulrike B. Hendgen‐Cotta, Michael Stumvoll, Matthias Blüher, John T. Heiker, Juliane Weiner   +23 more
doaj   +1 more source

Developmental and tissue-specific involvement of peroxisome proliferator-activated receptor-alpha in the control of mouse uncoupling protein-3 gene expression.

, 2013
Uncoupling protein-3 (UCP3) is a member of the mitochondrial carrier family expressed preferentially in skeletal muscle and heart. It appears to be involved in metabolic handling of fatty acids in a way that minimizes excessive production of reactive ...
Villarroya i Gombau, Francesc, Villarroya i Terrade, Joan, Gonzalez, Frank J., Solanes Garcia, Gemma, Pedraza González, Neus, Rosell Mañé, Meritxell, Iglesias Coll, María del Rosario   +6 more
core   +1 more source

Possible involvement of uncoupling protein 1 in appetite control by leptin [PDF]

Experimental Biology and Medicine, 2011
Leptin reduces body fat by decreasing food intake and increasing energy expenditure. Uncoupling protein (UCP) 1, a key molecule for brown adipose tissue (BAT) thermogenesis, was reported to contribute to the stimulatory effect of leptin on energy expenditure.
Okamatsu-Ogura, Yuko, Nio-Kobayashi, Junko, Iwanaga, Toshihiko, Terao, Akira, Kimura, Kazuhiro, Saito, Masayuki   +5 more
openaire   +3 more sources

The Therapeutic Potential of Brown Adipocytes in Humans

Frontiers in Endocrinology, 2015
Obesity and its metabolic consequences represent a significant clinical problem. From a thermodynamic standpoint, obesity results from a discord in energy intake and expenditure.
Craig ePorter, Craig ePorter, Maria eChondronikola, Maria eChondronikola, Labros S Sidossis, Labros S Sidossis, Labros S Sidossis   +6 more
doaj   +1 more source

Brown adipose tissue in adult humans: A mini review

Journal of Clinical and Scientific Research, 2019
Adipose tissue is of two types: white adipose tissue (WAT) and brown adipose tissue (BAT). For a long time, it was considered that BAT is present only in hibernating animals and newborns, conferring them a protection from the cold environment.
V S Kiranmayi, K M Bhargav
doaj   +1 more source