Results 61 to 70 of about 73,799 (284)

Role of gut microbiota in the postnatal thermoregulation of Brandt’s voles

Cell Reports, 2023
Summary: Homeothermy is crucial for mammals. Postnatal growth is the key period for young offspring to acquire gut microbiota. Although gut microbiota may affect mammal thermogenesis, the impact of developmental regulation of gut microbiota on the ...
Tingbei Bo, Liqiu Tang, Xiaoming Xu, Min Liu, Jing Wen, Jinzhen Lv, Dehua Wang   +6 more
doaj   +1 more source

Histone acetylation modulates uncoupling protein1 expression in brown adipocytes

, 2016
Uncoupling protein 1 (UCP1) is a classical feature of brown adipocytes and understanding its regulatory mechanism will help in the development of a pharmacological approach for obesity and associated metabolic diseases.
Rajan, Anubama
core   +1 more source

The complementary and divergent roles of uncoupling proteins 1 and 3 in thermoregulation [PDF]

The Journal of Physiology, 2016
Key points Both uncoupling protein 1 (UCP1) and UCP3 are important for mammalian thermoregulation. UCP1 and UCP3 in brown adipose tissue mediate early and late phases of sympathomimetic thermogenesis, respectively. Lipopolysaccharide thermogenesis requires skeletal muscle UCP3 but not UCP1. Acute noradrenaline‐induced hyperthermia requires UCP1 but not
Riley, Christopher L., Dao, Christine, Kenaston, M. Alexander, Muto, Luigina, Kohno, Shohei, Nowinski, Sara M., Solmonson, Ashley D., Pfeiffer, Matthew, Sack, Michael N., Lu, Zhongping, FIERMONTE, Giuseppe, Sprague, Jon E., Mills, Edward M.   +12 more
openaire   +3 more sources

Fatty Acids Change the Conformation of Uncoupling Protein 1 (UCP1) [PDF]

Journal of Biological Chemistry, 2012
UCP1 catalyzes proton leak across the mitochondrial inner membrane to disengage substrate oxidation from ATP production. It is well established that UCP1 is activated by fatty acids and inhibited by purine nucleotides, but precisely how this regulation occurs remains unsettled.
Ajit S, Divakaruni, Dickon M, Humphrey, Martin D, Brand   +2 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Regulation of autophagy in chick myotube cultures: Effect of uncoupling mitochondrial oxidative phosphorylation

The Journal of Poultry Science, 2023
s: Skeletal muscles have a high demand for ATP, which is met largely through mitochondria oxidative phosphorylation. Autophagy is essential for the maintenance of skeletal muscle mass under catabolic conditions.
Kazuki Nakashima, Aiko Ishida
doaj   +1 more source

Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis

, 2007
Brown adipose tissue expressing uncoupling protein 1 (UCP1) is responsible for adaptive nonshivering thermogenesis giving eutherian mammals crucial advantage to survive the cold. The emergence of this thermogenic organ during mammalian evolution remained
P. B. Frappell, McAllan, B., Withers, K. W., B. M. McAllan, M. Klingenspor, M. Platzer, V. Hirschberg, McAllan, B. M., B. T. Firth, Burmester, T., T. Burmester, Jastroch, M., Frappell, P. B., Firth, B., K. W. Withers, Taudien, S., G. Heldmaier, Firth, B. T., Helwig, M., S. Taudien, Klingenspor, M., M. Jastroch, Withers, K., Fromme, T., Hirschberg, V., M. Helwig, T. Fromme, Frappell, P., Heldmaier, G., Platzer, M.   +29 more
core   +1 more source

Acute Ethanol Administration Rapidly Increases Phosphorylation of Conventional Protein Kinase C in Specific Mammalian Brain Regions in Vivo [PDF]

, 2007
Background Protein kinase C (PKC) is a family of isoenzymes that regulate a variety of functions in the central nervous system including neurotransmitter release, ion channel activity, and cell differentiation.
Morrow, A. Leslie, Besheer, Joyce, Sandeep Kumar, A. Leslie Morrow, O'Buckley, Todd K., Kumar, Sandeep, Todd K. O'Buckley, Clyde W. Hodge, Stephen P. Kelley, Joyce Besheer, Wilkie, Mary Beth, Hodge, Clyde W., Mary Beth Wilkie, Kelley, Stephen P.   +13 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Thermogenic Capacity of Human White-Fat: The Actual Picture^†

Proceedings, 2019
AIM: Cold exposure and exercise may increase thermogenic capacity of white adipose tissue (WAT), which could subsequently enhance energy expenditure and body weight loss.
Petros C. Dinas, Argyro Krase, Eleni Nintou, Alexandros Georgakopoulos, Marnie Granzotto, Marinos Metaxas, Eleni Karachaliou, Marco Rossato, Roberto Vettor, Panagiotis Georgoulias, Athanasios Z. Jamurtas, John Koutsikos, Konstantinos Athanasiou, Leonidas G. Ioannou, Paraskevi Gkiata, Andres E. Carrillo, Yiannis Koutedakis, George S. Metsios, Tiago S. Mayor, Sofia Chatziioannou, Andreas D. Flouris   +20 more
doaj   +1 more source