Results 81 to 90 of about 73,799 (284)

Uncoupling protein 3 and physical activity: the role of uncoupling protein 3 in energy metabolism revisited [PDF]

, 2003
Uncoupling protein 3 and physical activity: the role of uncoupling protein 3 in energy metabolism revisited. Schrauwen P, Hesselink M. Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, PO Box 616,
Schrauwen, P., Hesselink, M.K.C.
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Lim Homeobox 8 Is Essential for Beta Adrenergic Stimulation of Thermogenesis in Human Adipocytes

Cells
Catecholamines are crucial signaling molecules that initiate thermogenesis in adipocytes through beta-adrenergic receptors (ADRBs). Adipocyte catecholamine resistance is a common feature of pediatric obesity, often impeding weight loss and the ...
Katalin Gyurina, Ádám Radványi, László Sasi-Szabó, Enikő Felszeghy, Emese Rácz, Gábor Méhes, Andrea Kádár, Csaba Fekete, Tamás Röszer   +8 more
doaj   +1 more source

Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous expression system

, 1999
The human uncoupling protein 3 gene generates two mRNA transcripts, uncoupling protein 3L and uncoupling protein 3S, which are predicted to encode long and short forms of the uncoupling protein 3 protein, respectively.
Leibel, Rudolph L., Zhang, Chen-Yu, Chung, Wendy K., Hagen, Thilo, Lowell, Bradford B., Slieker, Lawrence J.   +5 more
core   +1 more source

Stimulation of uncoupling protein 1 expression by β-alanine in brown adipocytes

Archives of Biochemistry and Biophysics, 2022
Carnosine, which is abundant in meat, is a dipeptide composed of β-alanine and histidine, known to afford various health benefits. It has been suggested that carnosine can elicit an anti-obesity effect via induction and activation of brown/beige adipocytes responsible for non-shivering thermogenesis.
Tsukasa Hamaoka, Xiajie Fu, Shozo Tomonaga, Osamu Hashimoto, Masaru Murakami, Masayuki Funaba   +5 more
openaire   +2 more sources

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Uncoupling protein-3 sensitizes cells to mitochondrial-dependent stimulus of apoptosis

, 2004
The mitochondrial uncoupling protein-3 is a member of the mitochondrial carrier protein family. As a homologue of the thermogenic brown fat uncoupling protein-1, it possesses a mitochondrial uncoupling activity and thus can influence cell energy ...
Dejean, L., Solanes, G., Sibille, B., Villarroya, F., Camara, Y.   +4 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

1-Linoleoylglycerophosphocholine stimulates UCP1-dependent thermogenesis and mitochondrial respiration to combat obesity

Journal of Lipid Research
Obesity leads to numerous illnesses and metabolic disorders, with lysophosphatidylcholine levels declining in obese patients. However, the physiological role of lysophosphatidylcholine and the regulatory mechanisms involved in modulating obesity remain ...
Rui Wang, Tianfu Zhu, Jingxian Lu, Mengke Cheng, Xingyun Wang, Xirong Guo, Shan Huang, Jianfang Gao   +7 more
doaj   +1 more source

Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1;2/TNF [PDF]

, 2012
Introduction: Circadian rhythms play an important role in the body and in single cells. Rhythms of molecular clocks have not been investigated in synovial fibroblasts (SF) of patients with osteoarthritis (OA) and rheumatoid arthritis (RA).
Haas, Stefanie, Stefanie Haas, Rainer H Straub, Straub, Rainer H.   +3 more
core   +1 more source