Intricate Transcriptional Networks of Classical Brown and Beige Fat Cells [PDF]
Frontiers in Endocrinology, 2015 Brown adipocytes are a specialized cell type that is critical for adaptive thermogenesis, energy homeostasis and metabolism. In response to cold, both classical brown fat and the newly identified beige or brite cells are activated by β-adrenergic ...
Sean Bong Lee +2 more
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Brown and Beige Fat: Therapeutic Potential in Obesity [PDF]
Indonesian Biomedical Journal, 2014 BACKGROUND: The epidemic of obesity and type 2 diabetes presents a serious challenge to scientific and biomedical communities worldwide. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the ...
Anna Meiliana, Andi Wijaya
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Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis [PDF]
JCI InsightInterorgan crosstalk via secreted hormones and metabolites is a fundamental aspect of mammalian metabolic physiology. Beyond the highly specialized endocrine cells, peripheral tissues are emerging as an important source of metabolic hormones that ...
Zhimin Chen +5 more
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CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling [PDF]
Cell, 2020 Adipose tissues dynamically remodel their cellular composition in response to external cues by stimulating beige adipocyte biogenesis; however, the developmental origin and pathways regulating this process remain insufficiently understood owing to ...
Takeshi Yoneshiro +2 more
exaly +4 more sources
Cellular Origins of Beige Fat Cells Revisited. [PDF]
Diabetes, 2019 Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident precursors or through reprogramming of mature white adipocytes has been a topic of intense discussion ...
Shao M +6 more
europepmc +4 more sources
Beige fat is dispensable for the metabolic benefits associated with myostatin deletion. [PDF]
Mol Metab, 2021 Increasing muscle mass and activating beige fat both have great potential for ameliorating obesity and its comorbidities. Myostatin null mice have increased skeletal muscle mass and are protected from obesity and its sequelae. Deletion of myostatin has also been suggested to result in the activation of beige adipocytes, thermogenic fat cells with anti ...
Marchildon F +4 more
europepmc +3 more sources
The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice [PDF]
Nature Communications, 2023 Skeletal muscle and thermogenic adipose tissue are both critical for the maintenance of body temperature in mammals. However, whether these two tissues are interconnected to modulate thermogenesis and metabolic homeostasis in response to thermal stress ...
Lu Jin +25 more
doaj +2 more sources
Brown and beige fat: development, function and therapeutic potential [PDF]
Nature Medicine, 2013 Adipose tissue, best known for its role in fat storage, can also suppress weight gain and metabolic disease through the action of specialized, heat-producing adipocytes. Brown adipocytes are located in dedicated depots and express constitutively high levels of thermogenic genes, whereas inducible 'brown-like' adipocytes, also known as beige cells ...
Patrick Seale
exaly +3 more sources
Creatine kinase B mediates UCP1-independent beige fat thermogenesis via the futile creatine cycle in mice [PDF]
Molecular MetabolismObjectives: Creatine kinase B (CKB) is the main isoenzyme driving creatine kinase (CK) activity in classical brown adipocytes. However, the specific CK isoenzyme active in beige adipocytes remains unknown.
Jakub Bunk +6 more
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Post-translational control of beige fat biogenesis by PRDM16 stabilization. [PDF]
Nature, 2022 AbstractCompelling evidence shows that brown and beige adipose tissue are protective against metabolic diseases1,2. PR domain-containing 16 (PRDM16) is a dominant activator of the biogenesis of beige adipocytes by forming a complex with transcriptional and epigenetic factors and is therefore an attractive target for improving metabolic health3–8 ...
Wang Q +14 more
europepmc +3 more sources