Stepping Up Human Beige Fat Cell Production [PDF]
Cell Reports, 2018 Beige fat cells hold significant promise for reducing obesity and metabolic disease. Su et al. (2018) present a robust method to produce human beige adipocytes from pluripotent stem cells via the generation of an expandable intermediary population of ...
Wenli Yang, Patrick Seale
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Inducible UCP1 silencing: A lentiviral RNA-interference approach to quantify the contribution of beige fat to energy homeostasis. [PDF]
PLoS ONE, 2019 Energy consuming, heat-producing beige adipocytes, located in classic white adipose tissue (WAT), hold promise for the treatment of obesity. Few reports have quantitatively assessed the contribution of browned 'WAT' to energy expenditure. There is a need
Nicole Wen Mun Khor +2 more
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Brown and Beige Fat: Therapeutic Potential in Obesity
Indonesian Biomedical Journal, 2014 BACKGROUND: The epidemic of obesity and type 2 diabetes presents a serious challenge to scientific and biomedical communities worldwide. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the ...
Anna Meiliana, Andi Wijaya
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Silver nanoparticles inhibit beige fat function and promote adiposity [PDF]
Molecular Metabolism, 2019 Objective: Obesity is a complex chronic disease of high prevalence worldwide. Multiple factors play integral roles in obesity development, with rising interest focusing on the contribution of environmental pollutants frequent in modern society.
Lishu Yue +15 more
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CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling [PDF]
Cell, 2020 Takeshi Yoneshiro +2 more
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Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation [PDF]
Developmental Cell, 2020 Heejin Jun +2 more
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Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle [PDF]
Cell MetabolismVargas-Castillo A +17 more
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Post-translational control of beige fat biogenesis by PRDM16 stabilization. [PDF]
Nature, 2022 AbstractCompelling evidence shows that brown and beige adipose tissue are protective against metabolic diseases1,2. PR domain-containing 16 (PRDM16) is a dominant activator of the biogenesis of beige adipocytes by forming a complex with transcriptional and epigenetic factors and is therefore an attractive target for improving metabolic health3–8 ...
Wang Q +14 more
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Lysyl oxidase inhibition enhances browning of white adipose tissue and adaptive thermogenesis
Genes and Diseases, 2022 Accumulating evidence from both animal and human studies suggests that activation of beige fat increases cellular energy expenditure, ultimately reducing adiposity.
Chun Xing +4 more
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Cellular Origins of Beige Fat Cells Revisited. [PDF]
Diabetes, 2019 Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident precursors or through reprogramming of mature white adipocytes has been a topic of intense discussion ...
Shao M +6 more
europepmc +4 more sources