Results 31 to 40 of about 544,121 (186)
Lysyl oxidase inhibition enhances browning of white adipose tissue and adaptive thermogenesis
Genes and Diseases, 2022 Accumulating evidence from both animal and human studies suggests that activation of beige fat increases cellular energy expenditure, ultimately reducing adiposity.
Chun Xing +4 more
doaj +1 more source
Nature Communications, 2023 Thermogenic beige fat can reduce fat mass and improve metabolic health, yet the ability to form beige fat rapidly declines with age. Here, the authors show that targeting the age-related ramping of Pdgfrβ signalling restores the ageing adipose tissue ...
Abigail M. Benvie +5 more
doaj +1 more source
Thermogenic adipose tissue in energy regulation and metabolic health
Frontiers in Endocrinology, 2023 The ability to generate thermogenic fat could be a targeted therapy to thwart obesity and improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat cells that regulate energy balance. Both adipocytes share common morphological,
Siwen Xue, Derek Lee, Daniel C. Berry
doaj +1 more source
Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone [PDF]
Biology, 2019 Phillips KJ.
exaly +2 more sources
Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Xiangyin Kong, Yin Huang, Keli Liu
exaly +2 more sources
Functional and Genetic Characterization of Porcine Beige Adipocytes
Cells, 2022 Beige adipocytes are a distinct type of fat cells with a thermogenic activity that have gained substantial attention as an alternative cellular anti-obesity target in humans.
Lilan Zhang +9 more
doaj +1 more source
BMP4 facilitates beige fat biogenesis via regulating adipose tissue macrophages. [PDF]
J Mol Cell Biol, 2019 Thermogenic beige fat improves metabolism and prevents obesity. Emerging evidence shows that the activation of M2 macrophages stimulates beige adipogenesis, whereas the activation of M1 macrophages, which play a major role in inflammation, impedes beige ...
Qian SW +9 more
europepmc +2 more sources
Combating Obesity With Thermogenic Fat: Current Challenges and Advancements
Frontiers in Endocrinology, 2020 Brown fat and beige fat are known as thermogenic fat due to their contribution to non-shivering thermogenesis in mammals following cold stimulation. Beige fat is unique due to its origin and its development in white fat.
Ruping Pan +3 more
doaj +1 more source
Nature Communications, 2021 Beige and brown fat may influence systemic metabolism through secreted signals. Here the authors identify a panel of metabolites secreted from beige and brown fat cells, which signal to influence fat tissue and skeletal muscle metabolism and have anti ...
Anna Whitehead +19 more
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TGF-β receptor 1 regulates progenitors that promote browning of white fat
Molecular Metabolism, 2018 Objective: Beige/brite adipose tissue displays morphological characteristics and beneficial metabolic traits of brown adipose tissue. Previously, we showed that TGF-β signaling regulates the browning of white adipose tissue. Here, we inquired whether TGF-
Umesh D. Wankhade +10 more
doaj +1 more source