Results 41 to 50 of about 544,121 (186)
Adult Epicardial Fat Exhibits Beige Features [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2013 Context: Human epicardial fat has been designated previously as brown-like fat. The supraclavicular fat depot in man has been defined as beige coexistent with classical brown based on its gene expression profile. Objective: The aim of the study was ...
Harold S. Sacks +7 more
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Imaging adipose tissue browning using the TSPO-18kDa tracer [18F]FEPPA
Molecular Metabolism, 2019 Objectives: The browning of white adipose tissue (WAT) into beige has been proposed as a strategy to enhance energy expenditure to combat the growing epidemic of obesity.
S.V. Hartimath +8 more
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Nature Communications, 2021 Visceral adiposity is a risk factor for cognitive decline, but subcutaneous adipose tissue (SAT) is not and may be protective. Here, the authors show that beige adipocytes are indispensable for the neuroprotective effects of SAT.
De-Huang Guo +5 more
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Brite/beige fat and UCP1 — is it thermogenesis?
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2014 The presence of two distinct types of adipose tissue, which have opposing functions, has been known for decades. White adipose tissue (WAT) is the main tissue of energy storage, while brown adipose tissue (BAT) dissipates energy as heat and is required for non-shivering thermoregulation.
Keipert, Susanne, Jastroch, Martin
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The significance of beige and brown fat in humans [PDF]
Endocrine Connections, 2017 Abstract Promotion of brown adipose tissue (BAT) activity or browning of white adipose tissue has shown great potential as anti-obesity strategy in numerous preclinical models. The discovery of active BAT in humans and the recent advances in the understanding of human BAT biology and function have significantly propelled this field of
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LIGHT/TNFSF14 signaling attenuates beige fat biogenesis [PDF]
The FASEB Journal, 2018 ABSTRACT The physiologic signals that regulate beige adipogenesis remain incompletely understood, especially those that limit browning and prevent overexpenditure of energy. In this study, the TNF family member cytokine lymphotoxin‐like inducible protein that competes with glycoprotein D for herpesvirus entry on T
Yanbo, Kou +9 more
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Adipose tissue browning for the treatment of obesity and metabolic diseases [PDF]
CellR4, 2020 Adipose tissue is the most abundant endocrine organ in humans with an important influence on many events throughout life. Many studies that highlight the different phenotypic characteristics of fat cells in adults are becoming more frequent. Perhaps, one
F. Arroyave, D. Montaño, F. Lizcano
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Human BAT possesses molecular signatures that resemble beige/brite cells. [PDF]
PLoS ONE, 2012 Brown adipose tissue (BAT) dissipates chemical energy and generates heat to protect animals from cold and obesity. Rodents possess two types of UCP-1 positive brown adipocytes arising from distinct developmental lineages: "classical" brown adipocytes ...
Louis Z Sharp +10 more
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Going immune on beige fat [PDF]
Science-Business eXchange, 2014 Two independent teams at UCSF and Harvard have found an immune-regulated pathway for beige fat formation and a hormone, METRNL, that activates it. Ember Therapeutics has an option to license the molecule, which could represent a new way to treat obesity.
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Brown and Beige Fat: Molecular Parts of a Thermogenic Machine [PDF]
Diabetes, 2015 The epidemic of obesity and type 2 diabetes has increased interest in pathways that affect energy balance in mammalian systems. Brown fat, in all of its dimensions, can increase energy expenditure through the dissipation of chemical energy in the form of heat, using mitochondrial uncoupling and perhaps other pathways.
Cohen, Paul, Spiegelman, Bruce M.
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