Results 41 to 50 of about 10,902 (169)
Going immune on beige fat [PDF]
Science-Business eXchange, 2014 Two independent teams at UCSF and Harvard have found an immune-regulated pathway for beige fat formation and a hormone, METRNL, that activates it. Ember Therapeutics has an option to license the molecule, which could represent a new way to treat obesity.
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LIGHT/TNFSF14 signaling attenuates beige fat biogenesis [PDF]
The FASEB Journal, 2018 ABSTRACT The physiologic signals that regulate beige adipogenesis remain incompletely understood, especially those that limit browning and prevent overexpenditure of energy. In this study, the TNF family member cytokine lymphotoxin‐like inducible protein that competes with glycoprotein D for herpesvirus entry on T
Yanbo, Kou +9 more
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Metabolic regulation and the anti-obesity perspectives of human brown fat
Redox Biology, 2017 Activation of brown adipose tissue (BAT) in adult humans increase glucose and fatty acid clearance as well as resting metabolic rate, whereas a prolonged elevation of BAT activity improves insulin sensitivity.
Camilla Scheele, Søren Nielsen
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Finding a Needle in a Haystack: Identification of a Beige Fat Progenitor [PDF]
Cell, 2020 Oguri and colleagues use single-cell RNA sequencing to identify a beige adipocyte precursor cell that gives rise to thermogenic adipocytes in subcutaneous adipose tissue. These beige fat progenitors are marked by PDGFRα, Sca1, and CD81 and proliferate upon activation of FAK-signaling in response to the cold and irisin.
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A Method to Induce Brown/Beige Adipocyte Differentiation from Murine Preadipocytes
Bio-Protocol, 2021 Adipocytes exhibit different morphological and functional characteristics, depending on their anatomical location, developmental origin, and stimulus. While white adipocytes tend to accumulate energy as triglycerides, brown and beige adipocytes tend to ...
Andréa Rocha +3 more
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The great roundleaf bat (Hipposideros armiger) as a good model for cold-induced browning of intra-abdominal white adipose tissue. [PDF]
PLoS ONE, 2014 Inducing beige fat from white adipose tissue (WAT) is considered to be a shortcut to weight loss and increasingly becoming a key area in research into treatments for obesity and related diseases.
Yao Wang +9 more
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The Role of Thermogenic Fat Tissue in Energy Consumption
Current Issues in Molecular Biology, 2022 Mammalian adipose tissues are broadly divided into white adipose tissue (WAT) and thermogenic fat tissue (brown adipose tissue and beige adipose tissue).
Masato Horino +2 more
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Mitochondrial Uncoupling and Thermogenesis in Beige Fat [PDF]
Biophysical Journal, 2014 Beige adipocytes are a morphologically distinct type of fat cell that develop within white fat depots upon exposure to cold or high fat diet. These cells have emerged as a major contributor to adaptive thermogenenesis and control of obesity, along with brown fat, a classic thermogenic tissue. Indeed, similarly to brown adipocytes, beige adipocytes have
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Advanced Science, EarlyView.ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao +7 more
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IRX3 Overexpression Enhances Ucp1 Expression In Vivo
Frontiers in Endocrinology, 2021 ObjectiveThe Iroquois homeobox 3 (IRX3) gene was recently reported to be a functional downstream target of a common polymorphism in the FTO gene, which encodes an obesity-associated protein; however, the role of IRX3 in energy expenditure remains unclear.
Zhiyin Zhang +19 more
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