Transcriptional Control of Brown and Beige Fat Development and Function. [PDF]
Obesity (Silver Spring), 2019 Adipose tissue, once viewed as an inert organ of energy storage, is now appreciated to be a central node for the dynamic regulation of systemic metabolism. There are three general types of adipose tissue: white, brown, and brown‐in‐white or “beige” fat.
Shapira SN, Seale P.
europepmc +4 more sources
Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biology [PDF]
Biology of Sex DifferencesThis review takes a close look at the biology of brown and beige fat, not just as thermogenic tissues, but as active metabolic organs influenced by sex, hormones, age, and even environment.
Chikkamagaluru Gopalakrishna Shashank +2 more
doaj +2 more sources
CDK6 inhibits white to beige fat transition by suppressing RUNX1 [PDF]
Nature Communications, 2018 Abstract Whereas white adipose tissue depots contribute to the development of metabolic diseases, brown and beige adipose tissue has beneficial metabolic effects. Here we show that CDK6 regulates beige adipocyte formation.
Xiaoli Hou +13 more
openaire +6 more sources
Brown and Beige Fat: Physiological Roles beyond Heat Generation [PDF]
Cell Metabolism, 2015 Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered attention as a therapeutic intervention for obesity and metabolic diseases including type 2 diabetes. As we better understand the physiological roles of classical brown and beige adipocytes, it is becoming clear that BAT is not simply a heat-generating organ.
Kajimura, Shingo +2 more
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Inducible UCP1 silencing: A lentiviral RNA-interference approach to quantify the contribution of beige fat to energy homeostasis. [PDF]
PLoS ONE, 2019 Energy consuming, heat-producing beige adipocytes, located in classic white adipose tissue (WAT), hold promise for the treatment of obesity. Few reports have quantitatively assessed the contribution of browned 'WAT' to energy expenditure. There is a need
Nicole Wen Mun Khor +2 more
doaj +2 more sources
Inducible Brown Adipose Tissue, or Beige Fat, Is Anabolic for the Skeleton [PDF]
Endocrinology, 2013 Abstract It is known that insulin resistance and type 2 diabetes mellitus are associated with increased fractures and that brown adipose tissue (BAT) counteracts many if not all of the symptoms associated with type 2 diabetes. By the use of FoxC2AD+/Tg mice, a well-established model for induction of BAT, or beige fat, we present data ...
Beata Lecka-Czernik +2 more
exaly +3 more sources
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat [PDF]
Cell Reports, 2017 Promoting development and function of brown and beige fat may reduce obesity. Here, we show that fat SIRT6 expression is markedly induced by cold exposure and a β-adrenergic agonist. Deletion of SIRT6 in adipose tissue impairs the thermogenic function of brown adipocytes, causing a morphological "whitening" of brown fat, reduced oxygen (O2) consumption,
Lu Yao +8 more
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Fish oil as a potential activator of brown and beige fat thermogenesis. [PDF]
Adipocyte, 2018 Numerous studies have shown that feeding rodents n-3 polyunsaturated fatty acids attenuates adiposity. Moreover, meta-analyses of human dietary intervention studies indicate that fish oil (eicosapentaenoic and docosahexaenoic acid) supplementation might reduce waist circumference. A recent line of research suggests that browning of white adipose depots
Lund J, Larsen LH, Lauritzen L.
europepmc +5 more sources
Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation [PDF]
Developmental Cell, 2020 Heejin Jun +2 more
exaly +2 more sources
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle [PDF]
Cell MetabolismVargas-Castillo A +17 more
exaly +2 more sources