Results 21 to 30 of about 10,902 (169)
Nature Communications, 2023 Thermogenic beige fat can reduce fat mass and improve metabolic health, yet the ability to form beige fat rapidly declines with age. Here, the authors show that targeting the age-related ramping of Pdgfrβ signalling restores the ageing adipose tissue ...
Abigail M. Benvie +5 more
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Thermogenic adipose tissue in energy regulation and metabolic health
Frontiers in Endocrinology, 2023 The ability to generate thermogenic fat could be a targeted therapy to thwart obesity and improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat cells that regulate energy balance. Both adipocytes share common morphological,
Siwen Xue, Derek Lee, Daniel C. Berry
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Beige fat is dispensable for the metabolic benefits associated with myostatin deletion. [PDF]
Mol Metab, 2021 Increasing muscle mass and activating beige fat both have great potential for ameliorating obesity and its comorbidities. Myostatin null mice have increased skeletal muscle mass and are protected from obesity and its sequelae. Deletion of myostatin has also been suggested to result in the activation of beige adipocytes, thermogenic fat cells with anti ...
Marchildon F +4 more
europepmc +3 more sources
Insights into the neurochemical signature of the Innervation of Beige Fat. [PDF]
Mol Metab, 2018 The potential for brown adipose tissue (BAT) to be targeted as a therapeutic option to combat obesity has been heightened by the discovery of a brown-like form of inducible "beige" adipose tissue in white fat which has overlapping structural and functional properties to "classical" BAT.
Stefanidis A +5 more
europepmc +5 more sources
Transcriptional Control of Brown and Beige Fat Development and Function. [PDF]
Obesity (Silver Spring), 2019 Adipose tissue, once viewed as an inert organ of energy storage, is now appreciated to be a central node for the dynamic regulation of systemic metabolism. There are three general types of adipose tissue: white, brown, and brown‐in‐white or “beige” fat.
Shapira SN, Seale P.
europepmc +4 more sources
Functional and Genetic Characterization of Porcine Beige Adipocytes
Cells, 2022 Beige adipocytes are a distinct type of fat cells with a thermogenic activity that have gained substantial attention as an alternative cellular anti-obesity target in humans.
Lilan Zhang +9 more
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Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone [PDF]
Biology, 2019 Phillips KJ.
exaly +2 more sources
Combating Obesity With Thermogenic Fat: Current Challenges and Advancements
Frontiers in Endocrinology, 2020 Brown fat and beige fat are known as thermogenic fat due to their contribution to non-shivering thermogenesis in mammals following cold stimulation. Beige fat is unique due to its origin and its development in white fat.
Ruping Pan +3 more
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Nature Communications, 2021 Beige and brown fat may influence systemic metabolism through secreted signals. Here the authors identify a panel of metabolites secreted from beige and brown fat cells, which signal to influence fat tissue and skeletal muscle metabolism and have anti ...
Anna Whitehead +19 more
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Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Xiangyin Kong, Yin Huang, Keli Liu
exaly +2 more sources