Results 71 to 80 of about 8,254 (159)
Obesity Reviews, EarlyView.ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye +6 more
wiley +1 more source
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
STAR ProtocolsSummary: Research on inducing beige adipocytes to combat obesity and its comorbidities is growing, with stromal vascular fraction (SVF) from white adipose tissue showing potential to differentiate into both white and beige adipocytes.
Qiqi Tang +5 more
doaj +1 more source
CDK6 inhibits white to beige fat transition by suppressing RUNX1
Nature Communications, 2018 Beige adipocytes can arise from transdifferentiation of mature white adipocytes. Here the authors identify CDK6 as a key molecule involved in the white-to-beige adipocyte transdifferentiation and, therefore, as a regulator of organismal energy ...
Xiaoli Hou +13 more
doaj +1 more source
Human BAT possesses molecular signatures that resemble beige/brite cells. [PDF]
PLoS ONE, 2012 Brown adipose tissue (BAT) dissipates chemical energy and generates heat to protect animals from cold and obesity. Rodents possess two types of UCP-1 positive brown adipocytes arising from distinct developmental lineages: "classical" brown adipocytes ...
Louis Z Sharp +10 more
doaj +1 more source
Obesity Reviews, EarlyView.ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid +22 more
wiley +1 more source
Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function [PDF]
Nature Communications, 2016 AbstractCold temperatures induce formation of beige adipocytes, which convert glucose and fatty acids to heat, and may increase energy expenditure, reduce adiposity and lower blood glucose. This therapeutic potential is unrealized, hindered by a dearth of genetic tools to fate map, track and manipulate beige progenitors and ‘beiging’.
Daniel C. Berry +2 more
openaire +3 more sources
Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.ABSTRACT Obesity, a severe worldwide health concern, is characterized as an excessive deposit of fat in the human body. It has various ramifications that endanger human health and increase the financial expense. Obesity raises the risk of several illnesses, notably cardiovascular disease, NALFD, and diabetes, and has been associated with shorter ...
Sakhawat Riaz +6 more
wiley +1 more source
Cold adaptation in pigs depends on UCP3 in beige adipocytes [PDF]
Journal of Molecular Cell Biology, 2017 Pigs lack functional uncoupling protein 1 (UCP1) making them susceptible to cold. Nevertheless, several pig breeds are known to be cold resistant. The molecular mechanism(s) enabling such adaptation are currently unknown. Here, we show that this resistance is not dependent on shivering, but rather depends on UCP3 and white adipose tissue (WAT) browning.
Jun Lin +14 more
openaire +2 more sources
Shades of Brown: A Model for Thermogenic Fat
Frontiers in Endocrinology, 2015 Brown adipose tissue (BAT) is specialized to burn fuels to perform thermogenesis in defense of body temperature against cold. Recent discovery of metabolically active and relevant amounts of BAT in adult humans have made it a potentially attractive ...
Jon Michael Dempersmier, Hei Sook eSul
doaj +1 more source