Results 81 to 90 of about 8,254 (159)

Adaptation of White Adipocytes to Cooler Temperatures: Impacts on Energy Metabolism and Protein Acetylation

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Cultured white adipocytes exposed to 31°C undergo cell‐autonomous metabolic adaptation characterized by enhanced mitochondrial function and widespread remodeling of the mitochondrial acetylome. Acetyl‐proteomic and metabolomic profiling identified mitochondria‐associated proteins, including SHMT2 and PCCA, whose acetylation changes were linked to ...
Hiroyuki Mori, Hadla Hariri, William Moe, Sophia Durham, Yuridia Guzman, Emma Paulsson, Rachel C. Simmermon, Parth B. Bhanderi, Sydney K. Peterson, Mia J. Dickson, Charles R. Evans, Ormond A. MacDougald   +11 more
wiley   +1 more source

Chemokine receptor CCR1 restrains adipose tissue remodelling via cAMP/PKA/CREB signalling and adipocyte‒macrophage crosstalk in mice

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
CCR1 expression is significantly elevated in adipose tissue of obese individuals. Systemic and adipocyte‐specific Ccr1 deletion promotes fat browning via cAMP/PKA/CREB activation and M2 macrophage polarisation, protecting against obesity. Pharmacological blockade of CCR1 suppresses obesity progression, highlighting its potential as a novel target for ...
Suili Cai, Mengchen Ma, Yuqin Zhu, Mengru Shi, Xiaoyan Dai, Yujie Wang, Mengru Li, Yanwen Yu, Yajiao Wang, Liang Xu   +9 more
wiley   +1 more source

Biology of Beige Adipocyte and Possible Therapy for Type 2 Diabetes and Obesity

International Journal of Endocrinology, 2016
All mammals own two main forms of fat. The classical white adipose tissue builds up energy in the form of triglycerides and is useful for preventing fatigue during periods of low caloric intake and the brown adipose tissue instead of inducing fat ...
Fernando Lizcano, Diana Vargas
doaj   +1 more source

Isoliquiritigenin Enhances the Beige Adipocyte Potential of Adipose-Derived Stem Cells by JNK Inhibition

Molecules, 2020
Human adipose-derived stem cells (hASCs) can be isolated from fat tissue and have attracted interest for their potential therapeutic applications in metabolic disease.
Hanbyeol Moon, Jung-Won Choi, Byeong-Wook Song, Il-Kwon Kim, Soyeon Lim, Seahyoung Lee, Ki-Chul Hwang, Sang Woo Kim   +7 more
doaj   +1 more source

Therapeutic Potential of Water‐Based Anatolian Propolis Extract Against CAF Diet‐Induced Obesity and Its Metabolic Complications

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Water‐based Anatolian propolis extract attenuates CAF diet‐induced obesity‐related metabolic disturbances by improving dyslipidemia, hepatic injury, adipokine imbalance, and inflammatory status in C57BL/6 mice. ABSTRACT This study investigates the anti‐obesity effects of water‐based Anatolian propolis extract in mice with a cafeteria diet‐induced ...
Mehmet Kemal, Elif Şahin, Ali Kulaber, Sevil Kör, Ahmet Alver, Engin Yenilmez, Sevgi Kolaylı   +6 more
wiley   +1 more source

Brown and Beige Fat: Therapeutic Potential in Obesity

Indonesian Biomedical Journal, 2014
BACKGROUND: The epidemic of obesity and type 2 diabetes presents a serious challenge to scientific and biomedical communities worldwide. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the ...
Anna Meiliana, Andi Wijaya
doaj   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Human Islet miR‐199a‐5p and miR‐214‐3p Associate With Donor Age, BMI, and Sex and Mediate Cellular Aging in Islet‐Derived Cells

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Objectives Human islets are widely researched to understand pathophysiological mechanisms leading to diabetes. Sex, age, and body mass index (BMI) are key donor traits influencing islet function, which is also regulated by an intricate network of microRNAs.
Wilson K. M. Wong, Isabelle El‐Azzi, Aditya Nachanekar, Ehsan Alvandi, Nhan Ho Trong Pham, Hrishikesh P. Hardikar, Mya Polkamp, Vijit Saini, Feifei Cheng, Guozhi Jiang, Anja E. Sørensen, Yi Vee Chew, Helen E. Thomas, Thomas Loudovaris, Ronald C. W. Ma, Wayne J. Hawthorne, Louise T. Dalgaard, Mugdha V. Joglekar, Anandwardhan A. Hardikar   +18 more
wiley   +1 more source

Mitochondrial fission is associated with UCP1 activity in human brite/beige adipocytes

Molecular Metabolism, 2018
Objective: Thermogenic adipocytes (i.e. brown or brite/beige adipocytes) are able to burn large amounts of lipids and carbohydrates as a result of highly active mitochondria and enhanced uncoupled respiration, due to UCP1 activity.
Didier F. Pisani, Valentin Barquissau, Jean-Claude Chambard, Diane Beuzelin, Rayane A. Ghandour, Maude Giroud, Aline Mairal, Sophie Pagnotta, Saverio Cinti, Dominique Langin, Ez-Zoubir Amri   +10 more
doaj   +1 more source

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source