Results 81 to 90 of about 59,004 (177)

Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function [PDF]

Nature Communications, 2016
AbstractCold temperatures induce formation of beige adipocytes, which convert glucose and fatty acids to heat, and may increase energy expenditure, reduce adiposity and lower blood glucose. This therapeutic potential is unrealized, hindered by a dearth of genetic tools to fate map, track and manipulate beige progenitors and ‘beiging’.
Daniel C. Berry, Yuwei Jiang, Jonathan M. Graff   +2 more
openaire   +3 more sources

Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway

Cell Reports, 2018
Summary: Beige adipocytes are present in white adipose tissue (WAT) and have thermogenic capacity to orchestrate substantial energy metabolism and counteract obesity.
Xing Zhang, Yan Luo, Chunqing Wang, Xiaofeng Ding, Xin Yang, Dandan Wu, Floyd Silva, Zijiang Yang, Qin Zhou, Lu Wang, Xiaoqing Wang, Jianlin Zhou, Nathan Boyd, Michael Spafford, Mark Burge, Xuexian O. Yang, Meilian Liu   +16 more
doaj   +1 more source

Protein Kinase SGK2 Is Induced by the β3 Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis

Frontiers in Physiology, 2021
Brown and beige adipocytes are specialized to dissipate energy as heat. Sgk2, encoding a serine/threonine kinase, has been identified as a brown and beige adipocyte-specific gene in rodents and humans; however, its function in brown/beige adipocytes ...
Chul-Hong Park, Jiyoung Moon, Minsung Park, Helia Cheng, Jisu Lee, Ji Suk Chang   +5 more
doaj   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression

Journal of Experimental & Clinical Cancer Research, 2019
Background Emerging evidence supports the pivotal roles of adipocytes in breast cancer progression. Tumour induced beige/brown adipose tissue differentiation contributes to the hypermetabolic state of the breast cancer.
Qi Wu, Juanjuan Li, Zhiyu Li, Si Sun, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Yimin Zhang, Shengrong Sun, Changhua Wang   +10 more
doaj   +1 more source

Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity

Obesity Reviews, Volume 27, Issue 10, October 2026.
ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye, Ursula Hiden, Evelyn Jantscher‐Krenn, Herbert Fluhr, Jonathan C. Wells, Sonja Entringer, Mireille N. M. van Poppel   +6 more
wiley   +1 more source

BMP7 drives human adipogenic stem cells into metabolically active beige adipocytes [PDF]

, 2015
Adult humans have a substantial amount of inducible-brown (or beige) fat, which is associated with increased energy expenditure and reduced weight gain via thermogenesis.
Chung, Soonkyu, Temel, Ryan E., Meshail Okla, Soonkyu Chung, Jung‐Heun Ha, Ryan E. Temel, Ha, Jung-Heun, Okla, Meshail   +7 more
core   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, Volume 13, Issue 50, 7 September 2026.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

CDK6 inhibits white to beige fat transition by suppressing RUNX1

Nature Communications, 2018
Beige adipocytes can arise from transdifferentiation of mature white adipocytes. Here the authors identify CDK6 as a key molecule involved in the white-to-beige adipocyte transdifferentiation and, therefore, as a regulator of organismal energy ...
Xiaoli Hou, Yongzhao Zhang, Wei Li, Alexander J. Hu, Chi Luo, Wenhui Zhou, Jamie K. Hu, Stefano G. Daniele, Jinfeng Wang, Jinghao Sheng, Yongsheng Fan, Andrew S. Greenberg, Stephen R. Farmer, Miaofen G. Hu   +13 more
doaj   +1 more source

Human BAT possesses molecular signatures that resemble beige/brite cells. [PDF]

PLoS ONE, 2012
Brown adipose tissue (BAT) dissipates chemical energy and generates heat to protect animals from cold and obesity. Rodents possess two types of UCP-1 positive brown adipocytes arising from distinct developmental lineages: "classical" brown adipocytes ...
Louis Z Sharp, Kosaku Shinoda, Haruya Ohno, David W Scheel, Emi Tomoda, Lauren Ruiz, Houchun Hu, Larry Wang, Zdena Pavlova, Vicente Gilsanz, Shingo Kajimura   +10 more
doaj   +1 more source