Scalable Generation of Pre‐Vascularized and Functional Human Beige Adipose Organoids
Advanced Science, 2023 Obesity and type 2 diabetes are becoming a global sociobiomedical burden. Beige adipocytes are emerging as key inducible actors and putative relevant therapeutic targets for improving metabolic health.
Mélanie Escudero +17 more
doaj +1 more source
Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura +6 more
doaj +1 more source
The Role of Thermogenic Fat Tissue in Energy Consumption
Current Issues in Molecular Biology, 2022 Mammalian adipose tissues are broadly divided into white adipose tissue (WAT) and thermogenic fat tissue (brown adipose tissue and beige adipose tissue).
Masato Horino +2 more
doaj +1 more source
Latest Advancements on Combating Obesity by Targeting Human Brown/Beige Adipose Tissues
Frontiers in Endocrinology, 2022 Obesity is defined as overaccumulation of white adipose tissue in the body, mainly under the skin (subcutaneous adiposity) or in the abdominal cavity (visceral adiposity).
Ruping Pan +3 more
doaj +1 more source
“Beige” Cross Talk Between the Immune System and Metabolism
Frontiers in Endocrinology, 2019 With thymic senescence the epithelial network shrinks to be replaced by adipose tissue. Transcription factor TBX-1 controls thymus organogenesis, however, the same TBX-1 has also been reported to orchestrate beige adipose tissue development.
Krisztina Banfai +15 more
doaj +1 more source
Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation
Frontiers in Cell and Developmental Biology, 2020 Adipose progenitor cells, or preadipocytes, constitute a small population of immature cells within the adipose tissue. They are a heterogeneous group of cells, in which different subtypes have a varying degree of commitment toward diverse cell fates ...
Iryna Pyrina +8 more
doaj +1 more source
Matrix-Assisted Transplantation of Functional Beige Adipose Tissue. [PDF]
Diabetes, 2015 Novel, clinically relevant, approaches to shift energy balance are urgently needed to combat metabolic disorders such as obesity and diabetes. One promising approach has been the expansion of brown adipose tissues that express uncoupling protein (UCP) 1 and thus can uncouple mitochondrial respiration from ATP synthesis.
Tharp KM +8 more
europepmc +8 more sources
Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine [PDF]
, 2014 Brown adipocytes help to maintain body temperature by the expression of a unique set of genes that facilitate cellular metabolic events including uncoupling protein 1-dependent thermogenesis.
Christian, Mark, Christian, M
core +1 more source
An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications. [PDF]
Rev Endocr Metab Disord, 2023 <jats:title>Abstract</jats:title><jats:p>Adipose tissue, including white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue, is vital in modulating whole-body energy metabolism. While WAT primarily stores energy,
Ghesmati Z +5 more
europepmc +2 more sources
Adipose-derived mesenchymal stromal/stem cells : tissue localization, characterization, and heterogeneity [PDF]
, 2012 Adipose tissue as a stem cell source is ubiquitously available and has several advantages compared to other sources. It is easily accessible in large quantities with minimal invasive harvesting procedure, and isolation of adipose-derived mesenchymal ...
Helmut Geiger +3 more
core +1 more source