Results 21 to 30 of about 9,335 (162)
The Role of Thermogenic Fat Tissue in Energy Consumption
Current Issues in Molecular Biology, 2022 Mammalian adipose tissues are broadly divided into white adipose tissue (WAT) and thermogenic fat tissue (brown adipose tissue and beige adipose tissue).
Masato Horino +2 more
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Latest Advancements on Combating Obesity by Targeting Human Brown/Beige Adipose Tissues
Frontiers in Endocrinology, 2022 Obesity is defined as overaccumulation of white adipose tissue in the body, mainly under the skin (subcutaneous adiposity) or in the abdominal cavity (visceral adiposity).
Ruping Pan +3 more
doaj +1 more source
“Beige” Cross Talk Between the Immune System and Metabolism
Frontiers in Endocrinology, 2019 With thymic senescence the epithelial network shrinks to be replaced by adipose tissue. Transcription factor TBX-1 controls thymus organogenesis, however, the same TBX-1 has also been reported to orchestrate beige adipose tissue development.
Krisztina Banfai +15 more
doaj +1 more source
Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation
Frontiers in Cell and Developmental Biology, 2020 Adipose progenitor cells, or preadipocytes, constitute a small population of immature cells within the adipose tissue. They are a heterogeneous group of cells, in which different subtypes have a varying degree of commitment toward diverse cell fates ...
Iryna Pyrina +8 more
doaj +1 more source
The Gq signalling pathway inhibits brown and beige adipose tissue. [PDF]
Nat Commun, 2016 AbstractBrown adipose tissue (BAT) dissipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates with leanness in human adults. Here we profile G protein-coupled receptors (GPCRs) in brown adipocytes to identify druggable regulators of BAT. Twenty-one per cent of the GPCRs link to the Gq family, and inhibition of
Klepac K +18 more
europepmc +7 more sources
JCI Insight, 2021 BACKGROUND Beige and brown adipose tissue (BAT) are associated with improved metabolic homeostasis. We recently reported that the β3-adrenergic receptor agonist mirabegron induced beige adipose tissue in obese insulin-resistant subjects, and this was ...
Brian S. Finlin +12 more
doaj +1 more source
MicroRNA-33 Inhibits Adaptive Thermogenesis and Adipose Tissue Beiging [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2021 Objective: Recent studies have identified key transcriptional regulators of brown adipose tissue (BAT) differentiation and function, but posttranscriptional control of this network by microRNAs remains incompletely understood.
Milessa Silva Afonso +13 more
openaire +2 more sources
Brown and Beige Fat: Therapeutic Potential in Obesity
Indonesian Biomedical Journal, 2014 BACKGROUND: The epidemic of obesity and type 2 diabetes presents a serious challenge to scientific and biomedical communities worldwide. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the ...
Anna Meiliana, Andi Wijaya
doaj +1 more source
Thermogenic adipose tissue aging: Mechanisms and implications
Frontiers in Cell and Developmental Biology, 2022 Adipose tissue undergoes significant anatomical and functional changes with aging, leading to an increased risk of metabolic diseases. Age-related changes in adipose tissue include overall defective adipogenesis, dysfunctional adipokine secretion ...
Graciano da Nadyellem Silva +1 more
doaj +1 more source
TGF-β receptor 1 regulates progenitors that promote browning of white fat
Molecular Metabolism, 2018 Objective: Beige/brite adipose tissue displays morphological characteristics and beneficial metabolic traits of brown adipose tissue. Previously, we showed that TGF-β signaling regulates the browning of white adipose tissue. Here, we inquired whether TGF-
Umesh D. Wankhade +10 more
doaj +1 more source