Results 31 to 40 of about 4,384,512 (209)

Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins

open access: yesNature Communications, 2022
White adipose tissue browning plays an important role in regulating whole-body energy homeostasis and metabolism. Here the authors show that the HMGN nucleosome binding proteins epigenetically promote white adipocyte differentiation and modulate the rate
Ravikanth Nanduri   +9 more
doaj   +1 more source

Latest Advancements on Combating Obesity by Targeting Human Brown/Beige Adipose Tissues

open access: yesFrontiers in Endocrinology, 2022
Obesity is defined as overaccumulation of white adipose tissue in the body, mainly under the skin (subcutaneous adiposity) or in the abdominal cavity (visceral adiposity).
Ruping Pan   +3 more
doaj   +1 more source

The role of melanocortins and cytokines in human adipose tissue and adipocytes [PDF]

open access: yes, 2007
During the last decades obesity has become a major health problem in developed countries, and more recently also in the developing countries it is seriously affecting parts of the populations.
Hoch, Matthias
core   +1 more source

Effects of Different Fasting Modes Combined with Exercise Training on Browning of White Adipose Tissue in Mice [PDF]

open access: yesShipin Kexue
To investigate the effect of intermittent fasting (IF) combined with exercise on browning of white adipose tissue (WAT), we randomly divided male C57BL/6 mice aged 5–6 weeks into six groups: control (Con), exercise (Ex), alternate-day fasting (ADF ...
LI Yinhuan, WANG Xukai, SHI Jian, XU Linjing, ZHOU Lizi, LI Weiye, LIU Hui, LIU Chunhong
doaj   +1 more source

Unraveling White Adipose Tissue Heterogeneity and Obesity by Adipose Stem/Stromal Cell Biology and 3D Culture Models

open access: yesCells, 2023
The immune and endocrine dysfunctions of white adipose tissue are a hallmark of metabolic disorders such as obesity and type 2 diabetes. In humans, white adipose tissue comprises distinct depots broadly distributed under the skin (hypodermis) and as ...
Leandra S. Baptista   +4 more
doaj   +1 more source

A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences [PDF]

open access: yes, 2010
Depot-dependent differences in adipose tissue physiology may reflect specialized functions and local interactions between adipocytes and surrounding tissues.
Kelder, T.A.J.   +46 more
core   +3 more sources

Roles of FGFs as adipokines in adipose tissue development, remodeling, and metabolism

open access: yesFrontiers in Endocrinology, 2014
White and brown adipose tissues, which store and burn lipids, respectively, play critical roles in energy homeostasis. Fibroblast growth factors (FGFs) are signaling proteins with diverse functions in development, metabolism, and neural function. Among
Nobuyuki eItoh, Hiroya eOhta
doaj   +1 more source

Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus

open access: yesAdipocyte, 2021
Mammalian adipose tissue can be divided into two major types, namely, white adipose tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function of WAT is to store excess energy in the form of triglycerides, while BAT is a ...
Long Cheng   +13 more
doaj   +1 more source

Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ [PDF]

open access: yesProceedings of the Nutrition Society, 2001
The traditional role attributed to white adipose tissue is energy storage, fatty acids being released when fuel is required. The metabolic role of white fat is, however, complex. For example, the tissue is needed for normal glucose homeostasis and a role in inflammatory processes has been proposed. A radical change in perspective followed the discovery
P, Trayhurn, J H, Beattie
openaire   +2 more sources

Metabolic control by AMPK in white adipose tissue

open access: yesTrends in Endocrinology & Metabolism, 2023
White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new ...
Olga Göransson   +2 more
openaire   +2 more sources

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