Results 21 to 30 of about 131,653 (265)

FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue

Molecular Metabolism, 2017
Objective: Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates metabolic homeostasis. Previous work has suggested that impairment of FGF21 signaling in adipose tissue may occur through downregulation of the obligate FGF21 co ...
Kathleen R. Markan, Meghan C. Naber, Sarah M. Small, Lila Peltekian, Rachel L. Kessler, Matthew J. Potthoff   +5 more
doaj   +1 more source

Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease

Frontiers in Cardiovascular Medicine, 2020
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date several types of adipose tissue have been identified, namely white, brown, and beige, that reside in various specific anatomical locations throughout the body. The
Alan Chait, Laura J. den Hartigh
doaj   +1 more source

Mitochondrial dysfunction in white adipose tissue [PDF]

Trends in Endocrinology & Metabolism, 2012
Although mitochondria in brown adipose tissue and their role in non-shivering thermogenesis have been widely studied, we have only a limited understanding of the relevance of mitochondria in white adipose tissue (WAT) for cellular homeostasis of the adipocyte and their impact upon systemic energy homeostasis.
Christine M, Kusminski, Philipp E, Scherer   +1 more
openaire   +2 more sources

Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning

International Journal of Molecular Sciences, 2022
The present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. In rodents, when exposed to decreasing temperatures, females activate thermogenesis earlier. Results obtained in humans
Iker Gómez-García, Jenifer Trepiana, Alfredo Fernández-Quintela, Marta Giralt, María P. Portillo   +4 more
openaire   +5 more sources

Lytic cocktail: An effective method to alleviate severe burn induced hyper-metabolism through regulating white adipose tissue browning

Heliyon, 2022
Background: Browning of white adipose tissue is associated with elevated resting metabolic rates and is considered to be one of the indispensable causes of hypermetabolism in burn patients.
Meng Zhang, Peilang Yang, Tianyi Yu, Martin C. Harmsen, Min Gao, Dan Liu, Yan Shi, Yan Liu, Xiong Zhang   +8 more
doaj   +1 more source

Calcium sensing receptor as a novel mediator of adipose tissue dysfunction: mechanisms and potential clinical implications

Frontiers in Physiology, 2016
Obesity is currently a serious worldwide public health problem, reaching pandemic levels. For decades, dietary and behavioral approaches have failed to prevent this disease from expanding, and health authorities are challenged by the elevated prevalence ...
Roberto Bravo, Roberto Bravo, Pamela Mattar, Pamela Mattar, Ximena Diaz, Sergio Lavandero, Sergio Lavandero, Sergio Lavandero, Mariana Cifuentes   +8 more
doaj   +1 more source

Beige Adipose Tissue Identification and Marker Specificity—Overview

Frontiers in Endocrinology, 2021
Adipose tissue (AT) is classified based on its location, physiological and functional characteristics. Although there is a clear demarcation of anatomical and molecular features specific to white (WAT) and brown adipose tissue (BAT), the factors that ...
Anna-Claire Pilkington, Henry A. Paz, Henry A. Paz, Umesh D. Wankhade, Umesh D. Wankhade   +4 more
doaj   +1 more source

Obesity, white adipose tissue and cancer. [PDF]

FEBS J
White adipose tissue (WAT) is crucial for whole‐body energy homeostasis and plays an important role in metabolic and hormonal regulation. While healthy WAT undergoes controlled expansion and contraction to meet the body's requirements, dysfunctional WAT in conditions like obesity is characterized by excessive tissue expansion, alterations in lipid ...
Solsona-Vilarrasa E, Vousden KH.
europepmc   +3 more sources

De novo reconstruction of human adipose transcriptome reveals conserved lncRNAs as regulators of brown adipogenesis

Nature Communications, 2018
Long non-coding RNAs are known to regulate mouse white adipose tissue development and brown adipose tissue program expression. Here, the authors construct a roadmap for human long non-coding RNAs expressed in fetal brown adipose tissue, adult omental and
Chunming Ding, Yen Ching Lim, Sook Yoong Chia, Arcinas Camille Esther Walet, Shaohai Xu, Kinyui Alice Lo, Yanling Zhao, Dewen Zhu, Zhihui Shan, Qingfeng Chen, Melvin Khee-Shing Leow, Dan Xu, Lei Sun   +12 more
doaj   +1 more source

Expression profiles and gene set enrichment analysis of the transcriptomes from the cancer tissue, white adipose tissue and paracancer tissue with colorectal cancer [PDF]

PeerJ
Background Colorectal cancer (CRC) is one of the most common cancers worldwide and is related to diet and obesity. Currently, crosstalk between lipid metabolism and CRC has been reported; however, the specific mechanism is not yet understood.
Xiufeng Zhang, Rui Zhu, Ye Jiao, Halizere Simayi, Jialing He, Zhong Shen, Houdong Wang, Jun He, Suzhan Zhang, Fei Yang   +9 more
doaj   +2 more sources