Results 41 to 50 of about 257,277 (359)

FAM13A and POM121C are candidate genes for fasting insulin: functional follow-up analysis of a genome-wide association study [PDF]

, 2018
Aims/hypothesis: By genome-wide association meta-analysis, 17 genetic loci associated with fasting serum insulin (FSI), a marker of systemic insulin resistance, have been identified. To define potential culprit genes in these loci, in a cross-sectional
Arner, Peter, Dahlman, Ingrid, Kulyte, Agne, Lundbäck, Veroniqa, Marcus, Claude, Ryden, Mikael, Strawbridge, Rona J.   +6 more
core   +1 more source

Ethnic differences in adiposity and diabetes risk – insights from genetic studies [PDF]

, 2020
Type 2 diabetes is more common in non-Europeans and starts at a younger age and at lower BMI cut-offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of disease with a focus on the role of
Bell, J.D., Bell, J.D., Thomas, E.L., Thomas, E.L., Whitcher, B., Whitcher, B., Yaghootkar, H., Yaghootkar, H.   +7 more
core   +2 more sources

Spatial Metabolomics Reveals the Effects of Dietary Capsaicin Intervention on Interscapular Adipose Tissue Metabolome in Mice

Foods
Capsaicin is a polyphenol with a well-known anti-obesity potential, which could activate brown adipose tissue and promote the browning of white adipose tissue.
Haoqing Yang, Peiying Zheng, Jiamiao Hu, Zhongjing Lin, Natthida Sriboonvorakul, Shaoling Lin   +5 more
doaj   +1 more source

Effects of Different Fasting Modes Combined with Exercise Training on Browning of White Adipose Tissue in Mice [PDF]

Shipin Kexue
To investigate the effect of intermittent fasting (IF) combined with exercise on browning of white adipose tissue (WAT), we randomly divided male C57BL/6 mice aged 5–6 weeks into six groups: control (Con), exercise (Ex), alternate-day fasting (ADF ...
LI Yinhuan, WANG Xukai, SHI Jian, XU Linjing, ZHOU Lizi, LI Weiye, LIU Hui, LIU Chunhong
doaj   +1 more source

Unraveling White Adipose Tissue Heterogeneity and Obesity by Adipose Stem/Stromal Cell Biology and 3D Culture Models

Cells, 2023
The immune and endocrine dysfunctions of white adipose tissue are a hallmark of metabolic disorders such as obesity and type 2 diabetes. In humans, white adipose tissue comprises distinct depots broadly distributed under the skin (hypodermis) and as ...
Leandra S. Baptista, Karina R. Silva, Lara Jobeili, Lucile Guillot, Dominique Sigaudo-Roussel   +4 more
doaj   +1 more source

The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms [PDF]

, 2015
Objectives: The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.
Clark, S., Contarino, A., Cota, D., Diz-Chaves, Y., Fanelli, F., Grammatopoulos, Dimitris, Lehnert, Hendrik, Lu, B., Markovic, Danijela, Penicaud, L., Tabarin, A.   +10 more
core   +3 more sources

Polyunsaturated fatty acids stimulate de novo lipogenesis and improve glucose homeostasis during refeeding with high fat diet [PDF]

, 2017
The recovery of body weight after a period of caloric restriction is accompanied by an enhanced efficiency of fat deposition and hyperinsulinemia—which are exacerbated by isocaloric refeeding on a high fat diet rich in saturated and monounsaturated ...
Bianco, Francesca, Cancelliere, Rosa, Crescenzo, Raffaella, Dulloo, Abdul G., Giacco, Antonia, Iossa, Susanna, Liverini, Giovanna, Mazzoli, Arianna   +7 more
core   +1 more source

Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus

Adipocyte, 2021
Mammalian adipose tissue can be divided into two major types, namely, white adipose tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function of WAT is to store excess energy in the form of triglycerides, while BAT is a ...
Long Cheng, Jingkang Wang, Hongyu Dai, Yuhui Duan, Yongcheng An, Lu Shi, Yinglan Lv, Huimin Li, Chen Wang, Quantao Ma, Yaqi Li, Pengfei Li, Haifeng Du, Baosheng Zhao   +13 more
doaj   +1 more source

Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice [PDF]

, 2016
The present study aimed to determine the effect of thyroid hormone dysfunction on brown adipose tissue activity and white adipose tissue browning in mice.
Hankir, Mohammed [u.v.m.], Klöting, Nora, Kranz, Mathias, Kunath, Anne, Köhrle, Josef, Rijntjes, Eddy, Steinhoff, Karen, Weiner, Juliane, Zeisig, Vilia   +8 more
core   +1 more source

Metabolic control by AMPK in white adipose tissue

Trends in Endocrinology & Metabolism, 2023
White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new ...
Olga Göransson, Franziska Kopietz, Mark H. Rider   +2 more
openaire   +3 more sources