Results 51 to 60 of about 11,513 (248)

Sympathetic nerve innervation is required for beigeing in white fat

Physiological Reports, 2019
It is increasingly recognized that activation of beige adipocyte thermogenesis by pharmacological or genetic approaches increases energy expenditure and alleviates obesity.
Qiang Cao, Jia Jing, Xin Cui, Hang Shi, Bingzhong Xue   +4 more
doaj   +1 more source

Continuous intake of Trehalose induces white adipose tissue Browning and Enhances energy metabolism

Nutrition & Metabolism, 2019
Background Trehalose is well known as a functional disaccharide with anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans.
Chikako Arai, Norie Arai, Shigeyuki Arai, Chiyo Yoshizane, Satomi Miyata, Akiko Mizote, Aki Suyama, Shin Endo, Toshio Ariyasu, Hitoshi Mitsuzumi, Shimpei Ushio   +10 more
doaj   +1 more source

Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization [PDF]

, 2016
Scope: Obesity is closely related to the imbalance of white adipose tissue storing excess calories, and brown adipose tissue dissipating energy to produce heat in mammals.
Bao, Yong P., Chen, Fen, Chen, Shi Y, Fu, Jian F, Shan, Yu J, Wang, An S, Yao, An J, Zhang, Hui Q, Zhang, Xiao H, Zhao, Jin S, Zhou, Zu Q   +10 more
core   +1 more source

Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat

eLife, 2021
While beige adipocytes have been found to associate with dense sympathetic neurites in mouse inguinal subcutaneous white fat (iWAT), little is known about when and how this patterning is established.
Jingyi Chi, Zeran Lin, William Barr, Audrey Crane, Xiphias Ge Zhu, Paul Cohen   +5 more
doaj   +1 more source

miRNAs as Influencers of Cell-Cell Communication in Tumor Microenvironment [PDF]

, 2020
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression.
Conti, Ilaria, Laface, Ilaria, Milani, Daniela, Neri, Luca M, Rimondi, Erika, Simioni, Carolina, Varano, Gabriele   +6 more
core   +1 more source

Improved glucose metabolism by Eragrostis tef potentially through beige adipocyte formation and attenuating adipose tissue inflammation. [PDF]

PLoS ONE, 2018
BACKGROUND:Teff is a staple food in Ethiopia that is rich in dietary fiber. Although gaining popularity in Western countries because it is gluten-free, the effects of teff on glucose metabolism remain unknown.
Mengistu Lemecha, Katsutaro Morino, Daniel Seifu, Takeshi Imamura, Fumiyuki Nakagawa, Aki Nagata, Takuya Okamato, Osamu Sekine, Satoshi Ugi, Hiroshi Maegawa   +9 more
doaj   +1 more source

PexRAP inhibits PRDM16-mediated thermogenic gene expression [PDF]

, 2017
How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear.
Dean, John M, Feng, Chu, He, Anyuan, Hsu, Fong-Fu, Lodhi, Irfan J, Park, Hongsuk, Semenkovich, Clay F, Song, Haowei, Tan, Min   +8 more
core   +3 more sources

Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis

Cell Reports, 2020
Summary: Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWATs).
Felipe Henriques, Alexander H. Bedard, Adilson Guilherme, Mark Kelly, Jingyi Chi, Peng Zhang, Lawrence M. Lifshitz, Karl Bellvé, Leslie A. Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, Lee S. Weinstein, Jiandie D. Lin, Paul Cohen, Michael P. Czech   +16 more
doaj   +1 more source

Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis

Nature Communications, 2023
Sympathetic innervation is essential for the development of functional beige fat that maintains body temperature and metabolic homeostasis, yet the molecular mechanisms controlling this innervation remain largely unknown. Here, we show that adipocyte YAP/
Xun Huang, Xinmeng Li, Hongyu Shen, Yiheng Zhao, Zhao Zhou, Yushuang Wang, Jingfei Yao, Kaili Xue, Dongmei Wu, Yifu Qiu   +9 more
doaj   +1 more source

Lsd1 prevents age-programed loss of beige adipocytes [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Over time, beige adipocytes gain a white adipocyte morphology and lose their thermogenic activity. Here we show that levels of the epigenetic eraser lysine-specific demethylase 1 (Lsd1) decrease in aging inguinal white adipose tissue concomitantly with beige fat cell decline.
Duteil, Delphine, Tosic, Milica, Willmann, Dominica, Georgiadi, Anastasia, Kanouni, Toufike, Schüle, Roland   +5 more
openaire   +5 more sources