Results 31 to 40 of about 1,078 (250)

Speculating the architecture of nothingness through void operations

ARSNET
This speculative design study aims to construct the idea of nothingness as an active and generative element of architecture. Nothingness, understood as voids, empty, and negative spaces, can be reinterpreted as a productive condition that opens up new ...
Fatiharla Imanisahda, Yandi Andri Yatmo
doaj   +1 more source

Wniknąć w nicość. Bernharda Weltego wykład o nadziei i rozpaczy [PDF]

Argument, 2013
The thought of Bernhard Welte, a philosopher of religion from Fribourg, many times touched upon the subject of nothingness. This article aims at presenting the function he ascribed to the idea of nothingness in the context of constitutive experience ...
Joachim PIECUCH
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Between being and nothingness: Sartre´s existential phenomenology of liberation

Veritas, 2003
O artigo tenta mostrar como a dialética sartreana do ser e do nada se afasta da concepção fundamental heideggeriana do Dasein enquanto ser-no-mundo, na medida em que seu modo de ser e autocompreensão existenciais conduzem-no em última análise à sua ...
Oliveira Junior, Nythamar Hilario Fernandes de
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Philosophische Übersetzung zwischen "sprachlicher Gewaltanwendung" und translativer Hermeneutik. Translatorische Überlegungen aus der Sicht der Übersetzung(en) von Jean-Paul Sartres 'L'être et le néant'

Labyrinth: An International Journal for Philosophy, Value Theory and Sociocultural Hermeneutics, 2019
Philosophical translation between "linguistic violence" and translative hermeneutics. Translational considerations from the perspective of the translation(s) of Jean-Paul Sartre's L'être et le néant   The establishment of translatology as a scientific ...
Yvanka Raynova
doaj   +5 more sources

Heidegger, Nothingness, and Presence: Between Parmenides and Laozi

Filozofia
This contribution reconsiders standard accounts of Heidegger’s concept of being as presence by tracing other moments revealed in his thinking of nothingness, emptiness, and the clearing in the context of his European and East Asian sources.
Eric S. Nelson
doaj   +1 more source

Byt i nicość w myśli Mistrza Eckharta. Początki niemieckiej filozofii woli [PDF]

Argument, 2013
The article is devoted to Meister Eckhart’s interpretation of ontological structures of reality in which the concepts of being, nothingness, existence, and Godhead play an important role. The article discusses: 1.
Piotr AUGUSTYNIAK
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