Results 41 to 50 of about 1,078 (250)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

A dessublimação emancipadora de Sartre

DoisPontos, 2006
Short historical and cultural sketch of France's decisive years during the Second World War, between occupation and resistance, refracted by the prism of the Sartrean figure of the engagé intellectual, wich was bor out of this conjuncture of sharp ...
Cristina Diniz Mendonça
doaj  

Une subjectivation extravagante. Métaphysique des tubes, d’Amélie Nothomb

Carnets, 2012
From Prétextat Tach to Melvin Mapple, Nothomb’s fictional world is full of extravagantly obese characters. They are bits of nothingness surrounded by a fat substance, a nothingness that takes more and more room, invades and eventually consumes everything.
Cristina Álvares
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

O lugar do "nada" no horizonte da crítica heideggeriana a noção de ciência tradicional

Cadernos Cajuína
RESUMO: O presente trabalho tem o objetivo de explicitar a crítica do filósofo alemão Martin Heidegger a ciência tradicional, que ao longo do tempo ignora a questão do nada como um aspecto negativo na busca pela descoberta cientifica.
Bruno José do Nascimento Oliveira
doaj   +3 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

A Short Talk about Being and Nothing

Asian Studies
I wonder how to approach the questions of being and nothing when they are posed to us in all seriousness. In cultural and philosophical history, several conceptions of being and nothing and several ways of solving these questions have appeared.
Andrej Ule
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

“Nothingness”—A Comparative-Philosophical Interaction in the Field between East and West

Asian Studies
In our digital age, translation software has come a long way, and in the context of business correspondence the cultural differences between languages have been reduced.
Hisaki Hashi
doaj   +1 more source

An approach to the notions of anxiety and despair in Sören Kierkegaard and his role in the concrete relations with the other of Jean Paul Sartre

Pensamiento. Revista de Investigación e Información Filosófica, 2019
In the following article we will analyze the notions of anxiety and despair developed by Sören Kierkegaard in The Concept of Anxiety and in the Treaty of Despair in order to highlight their importance for this Danish author and, in turn, we will glimpse ...
María Fernanda Guevara Riera
doaj   +1 more source