Results 41 to 50 of about 1,081 (250)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A dessublimação emancipadora de Sartre

DoisPontos, 2006
Short historical and cultural sketch of France's decisive years during the Second World War, between occupation and resistance, refracted by the prism of the Sartrean figure of the engagé intellectual, wich was bor out of this conjuncture of sharp ...
Cristina Diniz Mendonça
doaj  

Une subjectivation extravagante. Métaphysique des tubes, d’Amélie Nothomb

Carnets, 2012
From Prétextat Tach to Melvin Mapple, Nothomb’s fictional world is full of extravagantly obese characters. They are bits of nothingness surrounded by a fat substance, a nothingness that takes more and more room, invades and eventually consumes everything.
Cristina Álvares
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

O lugar do "nada" no horizonte da crítica heideggeriana a noção de ciência tradicional

Cadernos Cajuína
RESUMO: O presente trabalho tem o objetivo de explicitar a crítica do filósofo alemão Martin Heidegger a ciência tradicional, que ao longo do tempo ignora a questão do nada como um aspecto negativo na busca pela descoberta cientifica.
Bruno José do Nascimento Oliveira
doaj   +3 more sources

Wittgenstein on Being (and Nothingness)

Rivista Italiana di Filosofia del Linguaggio, 2023
In this paper, I present an interpretation of Wittgenstein's remarks on the experience of wonder at the existence of the world. According to this interpretation, Wittgenstein's feeling of wonder stems from perceiving the existence of the world as an absolute miracle, that is, as a fact that is in principle beyond explanation.
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A Short Talk about Being and Nothing

Asian Studies
I wonder how to approach the questions of being and nothing when they are posed to us in all seriousness. In cultural and philosophical history, several conceptions of being and nothing and several ways of solving these questions have appeared.
Andrej Ule
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

An approach to the notions of anxiety and despair in Sören Kierkegaard and his role in the concrete relations with the other of Jean Paul Sartre

Pensamiento. Revista de Investigación e Información Filosófica, 2019
In the following article we will analyze the notions of anxiety and despair developed by Sören Kierkegaard in The Concept of Anxiety and in the Treaty of Despair in order to highlight their importance for this Danish author and, in turn, we will glimpse ...
María Fernanda Guevara Riera
doaj   +1 more source