Results 91 to 100 of about 1,058,148 (324)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Parametric Constructive Kripke-Semantics for Standard Multi-Agent Belief and Knowledge (Knowledge As Unbiased Belief)

, 2012
We propose parametric constructive Kripke-semantics for multi-agent KD45-belief and S5-knowledge in terms of elementary set-theoretic constructions of two basic functional building blocks, namely bias (or viewpoint) and visibility, functioning also as ...
Kramer, Simon, Sack, Joshua
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Mutual Knowledge of Rationality in the Electronic Mail Game [PDF]

This paper reexamines the paradoxical aspect of the electronic mail game (Rubinstein, 1989). The electronic mail game is a coordination game with payoff uncertainty.
Akira Tanaka, Koji Takamiya
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Predictors and Associates of Problem–Reaction–Solution: Statistical Bias, Emotion-Based Reasoning, and Belief in the Paranormal

SAGE Open, 2018
Major conspiracy theorists propose that problem–reaction–solution (PRS) functions as a mechanism for constructing and exaggerating social problems to garner populist support for the implementation (imposition) of laws that society would normally deem ...
Kenneth Drinkwater, Neil Dagnall, Andrew Denovan, Andrew Parker, Peter Clough   +4 more
doaj   +1 more source

Classification of COVID-19 with Belief Functions and Deep Neural Network. [PDF]

SN Comput Sci, 2023
Saravana Kumar E, Ramkumar P, Naveen HS, Ramamoorthy R, Naidu RCA.   +4 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Belief Merging and Judgment Aggregation in Fuzzy Setting

Advances in Fuzzy Systems, 2012
We explore how judgment aggregation and belief merging in the framework of fuzzy logic can help resolve the “Doctrinal Paradox.” We also illustrate the use of fuzzy aggregation functions in social choice theory.
Ismat Beg, Nabeel Butt
doaj   +1 more source

EKSISTENSI HUTAN WONOSADI: ANTARA MITOS DAN KEARIFAN LINGKUNGAN

Jurnal Filsafat, 2016
Ecological perspective is a significant issue nowadays because there are many kinds of disaster around us stimulated by ecological disturbance. Actually, we have traditional knowledge and wisdoms to sustain the nature and protect it.
Sartini Sartini
doaj   +1 more source