Results 101 to 110 of about 13,623,354 (322)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A Cultural Algorithm for Optimal Design of Truss Structures

Latin American Journal of Solids and Structures
A cultural algorithm was utilized in this study to solve optimal design of truss structures problem achieving minimum weight objective under stress and deflection constraints. The algorithm is inspired by principles of human social evolution.
Shahin Jalili, Yousef Hosseinzadeh
doaj   +1 more source

On conditional belief functions

International Journal of Approximate Reasoning, 1994
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Yu, Chunhai, Arasta, Fahard
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Credal classification rule for uncertain data based on belief functions

Pattern Recognition, 2014
In this paper we present a new credal classification rule (CCR) based on belief functions to deal with the uncertain data. CCR allows the objects to belong (with different masses of belief) not only to the specific classes, but also to the sets of ...
Zhunga Liu, Q. Pan, J. Dezert, G. Mercier   +3 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Predictors and Associates of Problem–Reaction–Solution: Statistical Bias, Emotion-Based Reasoning, and Belief in the Paranormal

SAGE Open, 2018
Major conspiracy theorists propose that problem–reaction–solution (PRS) functions as a mechanism for constructing and exaggerating social problems to garner populist support for the implementation (imposition) of laws that society would normally deem ...
Kenneth Drinkwater, Neil Dagnall, Andrew Denovan, Andrew Parker, Peter Clough   +4 more
doaj   +1 more source

Parametric Constructive Kripke-Semantics for Standard Multi-Agent Belief and Knowledge (Knowledge As Unbiased Belief)

, 2012
We propose parametric constructive Kripke-semantics for multi-agent KD45-belief and S5-knowledge in terms of elementary set-theoretic constructions of two basic functional building blocks, namely bias (or viewpoint) and visibility, functioning also as ...
Kramer, Simon, Sack, Joshua
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source