Bellidifolin Ameliorates Isoprenaline-Induced Cardiac Hypertrophy by the Nox4/ROS Signalling Pathway Through Inhibiting BRD4 [PDF]
Cell Death Discovery, 2023 To date, there is no effective therapy for pathological cardiac hypertrophy, which can ultimately lead to heart failure. Bellidifolin (BEL) is an active xanthone component of Gentianella acuta (G. acuta) with a protective function for the heart. However,
Ai-Ying Li, Weizhe Liu, Dingyan Zhou
exaly +6 more sources
Bellidifolin Improves Pulmonary Artery Smooth Muscle Cells Proliferation by Targeting the IGFBP5-Mediated PI3K-AKT-mTOR Pathway and Dilates the Pulmonary Artery [PDF]
BiomoleculesPulmonary hypertension (PH) is a progressive disease that severely compromises right ventricular function, characterized by two major pathological features: pulmonary arterial constriction and pulmonary arterial remodeling.
Yulin Li, Zhan-Qiang Li, Xiangyun Gai
exaly +7 more sources
Bellidifolin From Gentianella acuta (Michx.) Hulten Protects H9c2 Cells From Hydrogen Peroxide-Induced Injury via the PI3K-Akt Signal Pathway [PDF]
Toxicology Reports, 2022 Cardiovascular disease is the most common disease in the world and the first among the causes of human death. Its morbidity and mortality increase annually, but no effective treatment is available.
Minhui Li, Congying Huang
exaly +6 more sources
Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization [PDF]
Frontiers in Pharmacology, 2021 Myocardial fibrosis is closely related to high morbidity and mortality. In Inner Mongolia, Gentianella amarella subsp. acuta (Michx.) J.M.Gillett (G. acuta) is a kind of tea used to prevent cardiovascular diseases.
Ai-Ying Li, Hong-Xia Yang, Jia-Huan Sun
exaly +7 more sources
Bellidifolin Inhibits Proliferation of A549 Cells by Regulating STAT3/COX-2 Expression and Protein Activity [PDF]
Journal of Oncology, 2020 Objectives. Bellidifolin (BEL) is one type of tetraoxygenated xanthone that is particularly found in Swertia and Gentiana (Gentianaceae). Despite its broad range of pharmacological activities, it is still unclear whether BEL could be used for lung cancer treatment. Hence, we presently demonstrate the roles of BEL towards the proliferative inhibition of
Yongqi Liu, Jin Xiaojie
exaly +6 more sources
Gentianella lutescens subsp. carpatica J. Holub.: Shoot Propagation In Vitro and Effect of Sucrose and Elicitors on Xanthones Production [PDF]
Plants, 2021 In vitro shoot culture of the endangered medicinal plant Gentianella lutescens was established from epicotyl explants cultured on MS basal medium with 0.2 mg L−1 6-benzylaminopurine (BA) and evaluated for xanthones content for the first time.
Dijana Krstić-Milošević +4 more
doaj +3 more sources
Xanthones Content in Swertia multicaulis D. Don from Nepal [PDF]
Molecules, 2018 The medicinal plant Swertia multicaulis D. Don was collected in Rasuwa District (Nepal) and the xanthone content of its ethyl acetate extracts was studied. The total amount of xanthones in S.
Binu Timsina +6 more
doaj +3 more sources
Frontiers in BioscienceBackground: This study aims to examine the roles and mechanisms of action of bellidifolin (BEL) in alleviating doxorubicin-mediated cardiotoxicity using network pharmacology and experimental validation .
Fan Gao, Cheng Dai
exaly +5 more sources
Network pharmacology and in vitro studies demonstrate modulation of fibrotic pathways by Swertia chirayita in pulmonary fibrosis [PDF]
Scientific ReportsVarious biological processes contribute to pulmonary fibrosis, which results in fibrotic foci that impede the exchange of gases between alveoli and capillaries.
Bharath H. B. +7 more
doaj +2 more sources
Moraea sisyrinchium inhibits proliferation, cell cycle, and migration of cancerous cells, and decreases angiogenesis in chick chorioallantoic membrane [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Experimental studies reported that some plants in the genus of Moraea (Iridaceae family) show anticancer potential. This study aimed to evaluate the effects of Moraea sisyrinchium on U87 glioblastoma multiforme and HepG2 liver cancer cells ...
Roghayeh Rashidi +7 more
doaj +2 more sources