Results 1 to 10 of about 133 (78)

Bellidifolin from Gentianella acuta (Michx.) Hulten protects H9c2 cells from hydrogen peroxide-induced injury via the PI3K-Akt signal pathway [PDF]

Toxicology Reports, 2022
Cardiovascular disease is the most common disease in the world and the first among the causes of human death. Its morbidity and mortality increase annually, but no effective treatment is available.
Siqi Li, Congying Huang, Xing Li, Xiangxi Meng, Rong Wen, Xiaodong Zhang, Chunhong Zhang, Minhui Li   +7 more
exaly   +6 more sources

Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4/ROS signalling pathway through inhibiting BRD4 [PDF]

Cell Death Discovery, 2023
To date, there is no effective therapy for pathological cardiac hypertrophy, which can ultimately lead to heart failure. Bellidifolin (BEL) is an active xanthone component of Gentianella acuta (G. acuta) with a protective function for the heart. However,
Ai-Ying Li
exaly   +5 more sources

Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization [PDF]

Frontiers in Pharmacology, 2021
Myocardial fibrosis is closely related to high morbidity and mortality. In Inner Mongolia, Gentianella amarella subsp. acuta (Michx.) J.M.Gillett (G. acuta) is a kind of tea used to prevent cardiovascular diseases.
Hong-Xia Yang, Ai-Ying Li
exaly   +7 more sources

Bellidifolin Inhibits SRY-Related High Mobility Group-Box Gene 9 to Block TGF-β Signalling Activation to Ameliorate Myocardial Fibrosis. [PDF]

Evid Based Complement Alternat Med, 2022
Myocardial fibrosis is the main morphological change of ventricular remodelling caused by cardiovascular diseases, mainly manifested due to the excessive production of collagen proteins. SRY-related high mobility group-box gene 9 (SOX9) is a new target regulating myocardial fibrosis. Bellidifolin (BEL), the active component of G.
Yao TT, Yang HX, Sun JH, Zhang Y, Zhang Y, Song QH, Liu WZ, Zhang JJ, Li AY.   +8 more
europepmc   +4 more sources

Bellidifolin Inhibits Proliferation of A549 Cells by Regulating STAT3/COX-2 Expression and Protein Activity. [PDF]

J Oncol, 2020
Objectives. Bellidifolin (BEL) is one type of tetraoxygenated xanthone that is particularly found in Swertia and Gentiana (Gentianaceae). Despite its broad range of pharmacological activities, it is still unclear whether BEL could be used for lung cancer treatment. Hence, we presently demonstrate the roles of BEL towards the proliferative inhibition of
Yan L, Yali L, Chenghao L, Caiqin F, Zhongbo Z, Weiyu R, Yu M, Xiaotian Z, Biwen W, Xiaojie J, Yongqi L.   +10 more
europepmc   +5 more sources

A novel bellidifolin intervention mitigates nonalcoholic fatty liver disease-like changes induced by bisphenol F [PDF]

Journal of Biomedical Research
As a potential endocrine-disrupting chemical, bisphenol F (BPF) may cause nonalcoholic fatty liver disease (NAFLD)-like changes, but the mechanisms under its pathogenesis as well as the intervention strategies remain unclear. Using the electron microscopy technology, along with LipidTOX Deep Red neutral and Bodipy 493/503 staining assays, we observed ...
Xue J, Zhang L, Tao J, Xie X, Wang X, Wu L, Du S, Tan N, Jin Y, Ju J, Fan J, Wang J, Huan F, Gao R.   +13 more
exaly   +4 more sources

Mechanisms of Bellidifolin in Treating Doxorubicin-Induced Cardiotoxicity: Network Pharmacology, Molecular Docking, and Experimental Verification

Frontiers in Bioscience
Background: This study aims to examine the roles and mechanisms of action of bellidifolin (BEL) in alleviating doxorubicin-mediated cardiotoxicity using network pharmacology and experimental validation .
Xinmeng Zhao, Zhenyang Zhong, Fan Gao, Jiangli Wu, Cheng Dai, Yalei Liu, Yu Liu, Aiying Li   +7 more
exaly   +5 more sources

Preparation, characterization and in vitro study of bellidifolin nano-micelles. [PDF]

RSC Adv, 2022
Bellidifolin (BEL), a xanthone compound, has significant therapeutic effectiveness in cardiac diseases such as arrhythmias.
Gao F, Chen Z, Zhou L, Xiao X, Wang L, Liu X, Wang C, Guo Q.   +7 more
europepmc   +3 more sources

Gentianella lutescens subsp. carpatica J. Holub.: Shoot Propagation In Vitro and Effect of Sucrose and Elicitors on Xanthones Production [PDF]

Plants, 2021
In vitro shoot culture of the endangered medicinal plant Gentianella lutescens was established from epicotyl explants cultured on MS basal medium with 0.2 mg L−1 6-benzylaminopurine (BA) and evaluated for xanthones content for the first time.
Dijana Krstić-Milošević, Nevena Banjac, Teodora Janković, Dragan Vinterhalter, Branka Vinterhalter   +4 more
doaj   +2 more sources

Network pharmacology and in vitro studies demonstrate modulation of fibrotic pathways by Swertia chirayita in pulmonary fibrosis [PDF]

Scientific Reports
Various biological processes contribute to pulmonary fibrosis, which results in fibrotic foci that impede the exchange of gases between alveoli and capillaries.
Bharath H. B., Farmiza Begum, Gautam Kumar, Jyothi Giridhar, Usha Y. Nayak, Fayaz S. M., Pawan Ganesh Nayak, Yogendra Nayak   +7 more
doaj   +2 more sources