Results 11 to 20 of about 182 (89)

Bellidifolin Inhibits SRY-Related High Mobility Group-Box Gene 9 to Block TGF-β Signalling Activation to Ameliorate Myocardial Fibrosis. [PDF]

Evid Based Complement Alternat Med, 2022
Myocardial fibrosis is the main morphological change of ventricular remodelling caused by cardiovascular diseases, mainly manifested due to the excessive production of collagen proteins. SRY-related high mobility group-box gene 9 (SOX9) is a new target regulating myocardial fibrosis. Bellidifolin (BEL), the active component of G.
Yao TT, Yang HX, Sun JH, Zhang Y, Zhang Y, Song QH, Liu WZ, Zhang JJ, Li AY.   +8 more
europepmc   +5 more sources

A Novel Bellidifolin Intervention Mitigates Nonalcoholic Fatty Liver Disease-Like Changes Induced by Bisphenol F [PDF]

Journal of Biomedical Research
As a potential endocrine-disrupting chemical, bisphenol F (BPF) may cause nonalcoholic fatty liver disease (NAFLD)-like changes, but the mechanisms under its pathogenesis as well as the intervention strategies remain unclear. Using the electron microscopy technology, along with LipidTOX Deep Red neutral and Bodipy 493/503 staining assays, we observed ...
Fei Huan, Junting Fan, Jingxian Tao
exaly   +4 more sources

Population-Related Variability in Qualitative and Quantitative Secondary Metabolite Profile of Gentianella austriaca (A. & J. Kern.) Holub

Plants, 2023
Phytochemical profiling of six natural populations of Gentianella austriaca was performed by HPLC identification and quantification of a number of secondary metabolites, and evaluation of time series of peak areas by chemometric analysis.
Zorica Popović, Vera Vidaković, Tatjana Mijalković, Dijana Krstić-Milošević   +3 more
doaj   +2 more sources

Inhibition of vascular smooth muscle cell proliferation by Gentiana lutea root extracts. [PDF]

PLoS ONE, 2013
Gentiana lutea belonging to the Gentianaceae family of flowering plants are routinely used in traditional Serbian medicine for their beneficial gastro-intestinal and anti-inflammatory properties. The aim of the study was to determine whether aqueous root
Rushendhiran Kesavan, Uma Rani Potunuru, Branislav Nastasijević, Avaneesh T, Gordana Joksić, Madhulika Dixit   +5 more
doaj   +3 more sources

Preparation, characterization and in vitro study of bellidifolin nano-micelles. [PDF]

RSC Adv, 2022
Bellidifolin (BEL), a xanthone compound, has significant therapeutic effectiveness in cardiac diseases such as arrhythmias.
Gao F, Chen Z, Zhou L, Xiao X, Wang L, Liu X, Wang C, Guo Q.   +7 more
europepmc   +3 more sources

The total xanthones extracted from Gentianella acuta alleviates HFpEF by activating the IRE1α/Xbp1s pathway. [PDF]

J Cell Mol Med
Abstract Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome characterized by pulmonary and systemic congestion resulting from left ventricular diastolic dysfunction and increased filling pressure. Currently, however, there is no evidence on effective pharmacotherapy for HFpEF.
Zhao L, Qin Y, Liu Y, An L, Liu W, Zhang C, Song Q, Dai C, Zhang J, Li A.   +9 more
europepmc   +2 more sources

[Retracted] Prevention and Treatment of Cardiovascular Diseases with Plant Phytochemicals: A Review

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Cardiovascular diseases (CVDs) are the world’s leading killers, accounting for 30% deaths. According to the WHO report, CVDs kill 17.9 million people per year, and there will be 22.2 million deaths from CVD in 2030. The death rates rise as people get older. Regarding gender, the death rate of women by CVD (51%) is higher than that of men (42%).
Rakesh Kumar Bachheti, Limenew Abate Worku, Yilma Hunde Gonfa, Meseret Zebeaman, Deepti, D. P. Pandey, Archana Bachheti, Muhammad Zia-Ul-Haq   +7 more
wiley   +1 more source

Effects of Four Compounds from Gentianella acuta (Michx.) Hulten on Hydrogen Peroxide-Induced Injury in H9c2 Cells. [PDF]

Biomed Res Int, 2019
In previous studies, Gentianella acuta (Michx.) Hulten was reported to contain xanthones, iridoids, terpenoids, and sterols and is mainly used to cure hepatitis, jaundice, fever, headache, and angina pectoris. In this study, we used bioassay guided fractionation to identify compounds from G.
Ren K, Su H, Lv LJ, Yi LT, Gong X, Dang LS, Zhang RF, Li MH.   +7 more
europepmc   +2 more sources

Identification of the most potent acetylcholinesterase inhibitors from plants for possible treatment of Alzheimer’s disease: a computational approach

Egyptian Journal of Medical Human Genetics, 2021
Background Being one of the rapidly growing dementia type diseases in the world, Alzheimer’s disease (AD) has gained much attention from researchers in the recent decades.
Bishajit Sarkar, Sayka Alam, Tiluttoma Khan Rajib, Syed Sajidul Islam, Yusha Araf, Md. Asad Ullah   +5 more
doaj   +1 more source

Structure-Activity Relationship and Prediction of the Electron-Transfer Potential of the Xanthones Series. [PDF]

ChemistryOpen, 2018
Better than a crystal ball: The structure–activity relationships of 31 xanthones are analyzed by using the ferric reducing antioxidant power assay to determine their electron‐transfer (ET) potential. The ET potential of the xanthones is dominated by four moieties (i.e.
Li X, Jiang Q, Chen B, Luo X, Chen D.
europepmc   +2 more sources