Results 31 to 40 of about 1,296,584 (365)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Burnout and Belonging: How the Costs and Benefits of Youth Activism Affect Youth Health and Wellbeing

Youth, 2023
Engagement in youth activism has been linked to both positive and negative wellbeing. Drawing on survey results from a sample of 636 youth participants in the ACLU Advocacy Institute, this study finds that although youth generally report greater benefits
Jerusha Osberg Conner, Emily Greytak, Carly D. Evich, Laura Wray-Lake   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The synergistic health syndemic of HIV and cancer of the cervix in women living with HIV in sub-Saharan Africa: Decrying the dearth of information

South African Medical Journal
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S Sibeko, M Sebitloane, S Moyo
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Is belonging always positive? Cultivating alternative and oppositional belonging at university

Introduction Student belonging is a hot topic in UK higher education, particularly since the beginning of the Covid-19 pandemic, given the significant disruption to face-to-face education (UPP Foundation, 2022; Wonkhe, 2022).
Horsburgh, Jo, Murray, Órla Meadhbh, Chiu, Yuan-Li   +2 more
core   +2 more sources

A comparative analysis of generalized additive models for obesity risk prediction

Healthcare Analytics
Obesity is a growing global health crisis, and traditional regression models often fail to capture the complex relationships between risk factors, limiting predictive accuracy and hindering effective public health interventions.
Olushina Olawale Awe, Olawale Abiodun Olaniyan, Ayorinde Emmanuel Olatunde, Ronel SewPaul, Natisha Dukhi   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Evaluation and Assessment of the ABATE Framework to Enhance Implicit Bias Training for Virtual Interviews in Medical Schools

MedEdPORTAL
Introduction The influence of implicit biases in virtual interviews must be addressed to ensure equity within the admissions process. ABATE is a mnemonic framework of five specific categories of implicit bias (affinity-based, backdrop-based, appearance ...
Veda Nagubandi, Caleb C. McKinney, Nicole M. Houle, Kristi D. Graves, Susan M. Cheng   +4 more
doaj   +1 more source