Results 41 to 50 of about 790,362 (267)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Social scientific research on the American West: current debates, novel methods, and new directions
Environmental Research Letters, 2019 Reviewing recent social science research on the western United States from multiple disciplines, we present a state-of-the-art synthesis for scholars and policymakers focused on the socioecological future of this distinctive region.
Paul Berne Burow +2 more
doaj +1 more source
An Example for Masculine Space in Turkish Culture: Village Rooms / Türk Kültüründe Eril Mekân Örneği; Köy Odaları [PDF]
Folklor/Edebiyat, 2019 This study elaborates on village rooms, which come forward as the space for social and cultural identities within Turkish cultural life. These rooms still exist in Cinis village of Erzurum Province.
Erdi Aksakal
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
BMC Health Services ResearchBackground Despite the many interventions that have been implemented in sub-Saharan Africa to improve the uptake of HIV testing and antiretroviral (ART) initiation services, the rates at which men are tested for HIV and initiated on ART have remained ...
Mbuzeleni Hlongwa, Edward Nicol
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Identity and Friendship in Hsu-Ming Teo´s Behind the Moon (2000)
Coolabah, 2015 In her second novel, Behind the Moon (2000), Hsu-Ming Teo explores the identity construction of three teenage friends and how they defy the notion of the „ideal‟ Australian as a heterosexual, Protestant, white, English-speaking, Australian-born of ...
Catalina Ribas Segura
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Loneliness and the cultural, spatial, temporal and generational bases of belonging
Australian Journal of Psychology, 2021 Sociologists and psychologists now agree on the significance of belonging to the experience of loneliness. Yet to date, this is unevenly reflected in both survey instruments and qualitative inquiry where the focus is mostly on belongingness attributed to
Adrian Franklin, Bruce Tranter
doaj +1 more source