Results 81 to 90 of about 1,296,584 (365)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Exploring Spaces of Belonging Through Analogies of 'Family': Perspectives and Experiences of Disengaged Young People at an Alternative School

, 2018
However, they viewed their current, ‘alternative’ places of schooling as spaces of belonging, framed through analogies of ‘family’ and discourses associated with a ‘home’.
Baroutsis, A, Mills, Martin, Mills, M, Baroutsis, Aspa, Aspa Baroutsis, Martin Mills   +5 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Sense of Belonging: Understanding the Emergence and Experience of the Construct, With a Focus on the Country Context [PDF]

openThis work is a review of the body of research on the emergence and the experience of sense of belonging. It looks at the various frameworks, concepts, and tools of measurement within the large literature, aiming to understand the complex construct of
IRMIS, YAREN
core  

Distal outcomes of communal goal mismatch: a longitudinal study of underrepresented students in STEM

Frontiers in Psychology
Using the goal congruity framework, this longitudinal study investigated whether communal goal mismatch predicted distal outcomes of STEM intentions, STEM identity, and a sense of belonging among students pursuing degrees in STEM fields.
Ashley Bonilla, Wesley Schultz, Anna Woodcock, Paul R. Hernandez   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Race, Gender, and Questions of Belonging

, 2017
InterDisciplines. Journal of History and Sociology Vol 7, No 1 (2016) Race, Gender, and Questions of Belonging Im Herbst 2015 habe ich erste Ergebnisse des Forschungprojektes auf der Jahrestagung der German Studies Association (GSA) in Washington, DC ...
Harders, Levke ; https://orcid.org/, Levke Harders   +1 more
core  

Young People Creating Belonging: spaces, sounds and sights [PDF]

, 2012
Report for ESRC-funded project exploring belonging among 'looked after' young people from across mainland and island Scotland.
Wilson, Sarah, Milne, EJ, Milne, Elisabeth-Jane   +2 more
core  

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source