Results 71 to 80 of about 804,323 (267)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Belonging: a meta-theme analysis of women’s community-making in group antenatal and postnatal care

Frontiers in Public Health
Health care systems are social institutions simulating microcosms of wider societies where unequal distribution of power and resources translate into inequities in health outcomes, experiences and access to services.
Anna Horn, Marsha Orgill, Deborah L. Billings, Deborah L. Billings, Wiedaad Slemming, Astrid Van Damme, Mathilde Crone, Malibongwe Gwele, Nathalie Leister, Ashna D. Hindori-Mohangoo, Katrien Beeckman, Susan Bradley, Manodj P. Hindori, Jedidia Abanga, Julia Ryan, Hana Bucinca, Christine McCourt   +16 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

“¡Hoy tenemos Patria!” La pertenencia nacional entre los jóvenes de un barrio en la Caracas post-Chávez

Cahiers des Amériques Latines
This article raises the problem of belonging "to the homeland" in Venezuela, a nation subsumed in a long standing political and economic crisis. Based on a visual ethnography guided by a photo-elicitation with young males, I analyze how they experience ...
Henry Moncrieff Zabaleta
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Looking back to move forward: Tracing students’ experiences of transitioning to university

JPHE
A growing body of research conceptualises students’ transitions into higher education as non-linear and multi-faceted, extending beyond the first months of university.
Angela Gayton, Piotr Wegorowski
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Multilevel determinants of school belonging: the moderating role of national safety climate

Frontiers in Education
IntroductionWhy do some students feel they belong at school while others do not? We examined how perceived school safety and teacher–student relationships relate to belonging across countries, and whether national safety modifies these links.MethodsUsing
Jose Fabián Elizondo-González, Jose Fabián Elizondo-González, Shreya Malla, Solange Barros-Bustos   +3 more
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

“We’re all Squares on a Screen”: Interpersonal and Intrapersonal Opportunities and Limitations of Online Intergroup Dialogue

Online Learning
Postsecondary institutions are seeing the need and searching for ways to prepare their students for life in an increasingly complex and often polarized society.
Grant Jackson, Sarah Schiffecker, Oleksandra Poquet   +2 more
doaj   +1 more source