Light chain myeloma and detection of free light chains in serum and urine of dogs and cats
Journal of Veterinary Internal Medicine, 2021 Background Detection of free light chains (fLC) in animals relies on protein electrophoresis or the Bence‐Jones protein test on urine. Objective To describe the detection of both serum fLC (sfLC) and urine fLC (ufLC) in 8 dogs and 2 cats using a ...
Robert Adam Harris +6 more
doaj +1 more source
Multiple Myeloma Presenting as Chest Wall Lesion: A Case Report [PDF]
International Journal of Anatomy Radiology and Surgery, 2021 Multiple myeloma is defined by >10% of clonal plasma cells in bone marrow or biopsy-proven extramedullary plasmacytoma and by the evidence of end-organ damage including bone lesions and renal insufficiency.
Prakriti R Patil +3 more
doaj +1 more source
A strategy for synthesis of pathogenic human immunoglobulin free light chains in E. coli. [PDF]
PLoS ONE, 2013 Monoclonal immunoglobulin light chains are normally synthesized in excess compared to the heavy chain partners and can be detected in serum and urine ("free" LC).
Paola Rognoni +8 more
doaj +1 more source
Cytological diagnosis of solitary plasmacytoma of the skull: A rare case report
Journal of the Scientific Society, 2015 Solitary plasmacytoma (SPC) of the skull (SPS) is rare, and only a few cases have been reported in the literature so far. Plasmacytoma of the skull has a wide spectrum of pathology, including a quite benign, SPC, and an extremely malignant, multiple ...
Mohamad Banyameen Iqbal +3 more
doaj +1 more source
Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties [PDF]
, 2002 The X-ray structure of an immunoglobulin light-chain dimer isolated from the urine as a 'Bence-Jones protein' from a patient with multiple myeloma and amyloidosis (Sea) was determined at 1.94 Angstrom resolution and refined to R and R-free factors of 0 ...
Bourne, P. C. +10 more
core +2 more sources
Solitary Plasmacytoma of Skull: A Rare Cytological Diagnosis [PDF]
Journal of Clinical and Diagnostic Research, 2013 Solitary Plasmacytoma of the Skull (SPS) is very rare and only 35 cases have been reported in the English literature. It remains controversial whether a solitary plasmacytoma of the skull is essentially identical with a Solitary Plasmacytoma of Bone (SPB)
MANMEET KAUR GILL +2 more
doaj +1 more source
Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]
, 2015 Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris +7 more
core +1 more source
Replacing Acid-Heat Precipitation with Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis Improves Detecting Bence-Jones proteinuria [PDF]
, 2019 Background: Detecting Bence-Jones protein in urine is essential for determining plasma cell dyscrasia and multiple myeloma. Conventionally, acid-heat precipitation assay is used for detecting Bence-jones protein in most medical laboratories; however ...
amirzargar, aliakbar
core +2 more sources
Brazilian Archives of Biology and Technology, 2001 The aim of this investigation was to evaluate the endocytosis of two Bence-Jones proteins by renal cells in order to elucidate the interference of their physical and chemical characteristics on nephrotoxicity.
Ana Lucia Nicastri +3 more
doaj +1 more source
Respiratory Medicine Case Reports, 2020 A 60-year-old man was admitted for ground glass opacity in the lower lung field and mediastinal lymphadenopathy. Blood tests revealed elevated serum IgM levels, and the urine test detected Bence-Jones protein.
Yuichi Adachi +12 more
doaj +1 more source