Results 41 to 50 of about 579,921 (281)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Uncertainty in GNN Learning Evaluations: A Comparison between Measures for Quantifying Randomness in GNN Community Detection

open access: yesEntropy
(1) The enhanced capability of graph neural networks (GNNs) in unsupervised community detection of clustered nodes is attributed to their capacity to encode both the connectivity and feature information spaces of graphs.
William Leeney, Ryan McConville
doaj   +1 more source

Critical Issues in the Management of Newborn Hearing Screening in the Time of COVID-19 in Umbria, Italy

open access: yesChildren, 2022
Hearing impairment is the most frequent of the sensorial defects in humans, and if not treated promptly, can severely impair cognitive and spoken language skills. For this reason, a universal newborn hearing screening (UNHS) has been established.
Valeria Gambacorta   +7 more
doaj   +1 more source

Face Detection with the Faster R-CNN

open access: yes, 2016
The Faster R-CNN has recently demonstrated impressive results on various object detection benchmarks. By training a Faster R-CNN model on the large scale WIDER face dataset, we report state-of-the-art results on two widely used face detection benchmarks,
Jiang, Huaizu, Learned-Miller, Erik
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

DIRECTIONS OF FINANCIAL SECURITY ENFORCEMENT IN THE CENTRAL ASIA COUNTRIES

open access: yesInternational Journal of Innovative Technologies in Economy, 2018
Article is devoted to the assessment and analysis of the level of financial security of the economies of the countries of Central Asia, and the definition of the criteria for the development of the financial system, its support and approval in the ...
Nurymova Saule, Yessentay Aigerim
doaj  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Phase-Covariant Quantum Benchmarks [PDF]

open access: yes, 2008
We give a quantum benchmark for teleportation and quantum storage experiments suited for pure and mixed test states. The benchmark is based on the average fidelity over a family of phase-covariant states and certifies that an experiment can not be ...
A. S. Holevo   +5 more
core   +1 more source

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