Results 41 to 50 of about 4,303 (287)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A unified approach to link small-strain shear modulus and liquefaction resistance of pumiceous sand

Soils and Foundations, 2022
Natural pumiceous (NP) sands containing pumice particles, a type of volcanic soil, are commonly found in the central part of the North Island in New Zealand.
Mohammad Bagher Asadi, Rolando P. Orense, Mohammad Sadeq Asadi, Michael J. Pender   +3 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Experimental Study of the Engineering Mechanical Properties of the Foundation Soil for Offshore Wind Power Platforms

Shock and Vibration, 2021
Most of the coastal beach zone in the world is rich in wind energy reserves and has great potential for offshore wind power development. However, the sedimentary environment in the coastal area is complex and changeable, and the nature of the foundation ...
Yi Fang, Yuejun Lv, XingYuan Zhou, Yanju Peng   +3 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Elastic Parameters of Intermediate Soils Based on Bender-Extender Elements Pulse Tests

Soils and Foundations, 2011
The elastic behaviour of compacted soils subjected to very small strains (smaller than 10 －5) is essential, because the serviceability of most geotechnical structures depends on soil elastic properties. Small-strain stiSness of soils was studied in the past years using diSerent experimental devices (mainly resonant columns).
Murillo, Carol, Sharifipour, Mohammad, Caicedo, Bernardo, Thorel, Luc, Dano, Christophe   +4 more
openaire   +3 more sources

Two-dimensional discrete element modelling of bender element tests on an idealised granular material [PDF]

Granular Matter, 2012
The small-strain (elastic) shear stiffness of soil is an important parameter in geotechnics. It is required as an input parameter to predict deformations and to carry out site response analysis to predict levels of shaking during earthquakes. Bender element testing is often used in experimental soil mechanics to determine the shear (S-) wave velocity ...
O’Donovan, J., O’Sullivan, C., Marketos, G.   +2 more
openaire   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Effect of earthquake excitation on circular tunnels: Numerical and experimental study

Measurement + Control, 2019
This paper studies the behaviour of circular tunnel subjected to dynamic excitation. Tunnels with three different diameters were selected to perform the shake table test at three different covers. The dry sandy soil was used for testing.
DK Singh, SR Karumanchi, A Mandal, YB Katpatal, A Usmani   +4 more
doaj   +1 more source