Results 51 to 60 of about 472,209 (346)

Strength and deformation modification factors of wood based composites for engineering design [PDF]

, 2008
This paper summarizes some of the findings from a comprehensive study concerning the performance of wood based composites in building construction. The presentation only focuses on the strength and deformation modification factors for engineering design ...
Enjily, V, Fan, M
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Effect of span-thickness ratio on bending properties of high-strength glass fiber reinforced composite unidirectional plate

Journal of Aeronautical Materials, 2022
Based on the three-point bending test, the bending performances of S6C10-800/AC318 composite unidirectional plates with different span-thickness ratios (hereinafter referred to as unidirectional plates) were tested, and the effect of span-thickness ratio
BAI Xin, WANG Yunying, WANG Yana, CHEN Xinwen, HE Yuhuai   +4 more
doaj   +1 more source

Development of timber concrete composite (TCC) beam with post-tensioning [PDF]

, 2020
Post-tensioning is a method of reinforcing (strengthening) concrete or other materials with high-strength steel strands or bars. The timber type that is used in all researches is the engineering timber products laminated veneer lumber (LVL) and glue ...
Obeed, Wissam Mushina
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Deep learning improves performance of topological bending waveguides

Optics Express
This study introduced design informatics using deep learning in a topological photonics system and applied it to a topological waveguide with a sharp bending structure to further reduce propagation loss. The sharp bend in the topological waveguide composed of two photonic crystals wherein dielectrics having C
Itsuki Sakamoto, Sho Okada, Nobuhiko Nishiyama, Xiao Hu, Tomohiro Amemiya   +4 more
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Ultra-Low-Loss Hollow-Core Anti-Resonant Fiber Combining Double-Tube Nesting and a Single-Layer Anti-Resonant Wall

Photonics
This study innovatively presents a hollow-core anti-resonant fiber integrating double-tube nesting and a single-layer anti-resonant wall. Featuring an exclusive two-layer cladding configuration along with an outer cladding circular ring, it differs ...
Xingtao Zhao, Mu Wang, Wenke Zhang, Jinlong Luo, Chang Liu, Sai Liu, Juncheng Li   +6 more
doaj   +1 more source

Ultra low bending loss equiangular spiral photonic crystal fibers in the terahertz regime [PDF]

, 2012
An Equiangular Spiral Photonic Crystal Fiber (ES-PCF) design in Topas® for use in the Terahertz regime is presented. The design shows ultra low bending loss and very low confinement loss compared to conventional Hexagonal PCF (H-PCF).
Agrawal, A., Grattan, K. T. V., Kejalakshmy, N., Kumar, A., Rahman, B. M., Uthman, M.   +5 more
core   +2 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source