Results 51 to 60 of about 473,409 (306)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Effect of span-thickness ratio on bending properties of high-strength glass fiber reinforced composite unidirectional plate

Journal of Aeronautical Materials, 2022
Based on the three-point bending test, the bending performances of S6C10-800/AC318 composite unidirectional plates with different span-thickness ratios (hereinafter referred to as unidirectional plates) were tested, and the effect of span-thickness ratio
BAI Xin, WANG Yunying, WANG Yana, CHEN Xinwen, HE Yuhuai   +4 more
doaj   +1 more source

A continuous-stress tetrahedron for finite strain problems [PDF]

, 2019
A finite-strain tetrahedron with continuous stresses is proposed and analyzed. The complete stress tensor is now a nodal tensor degree-of-freedom, in addition to displacement.
Areias, Pedro, Carapau, Fernando, Lopes, José Carrilho, Rabczuk, Timon   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Ultra low bending loss equiangular spiral photonic crystal fibers in the terahertz regime [PDF]

, 2012
An Equiangular Spiral Photonic Crystal Fiber (ES-PCF) design in Topas® for use in the Terahertz regime is presented. The design shows ultra low bending loss and very low confinement loss compared to conventional Hexagonal PCF (H-PCF).
Agrawal, A., Grattan, K. T. V., Kejalakshmy, N., Kumar, A., Rahman, B. M., Uthman, M.   +5 more
core   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Ultra-Low-Loss Hollow-Core Anti-Resonant Fiber Combining Double-Tube Nesting and a Single-Layer Anti-Resonant Wall

Photonics
This study innovatively presents a hollow-core anti-resonant fiber integrating double-tube nesting and a single-layer anti-resonant wall. Featuring an exclusive two-layer cladding configuration along with an outer cladding circular ring, it differs ...
Xingtao Zhao, Mu Wang, Wenke Zhang, Jinlong Luo, Chang Liu, Sai Liu, Juncheng Li   +6 more
doaj   +1 more source

Genre-Bending in Early Modern Performative Culture [PDF]

The Italianist, 2020
When a play has a character called ‘Eteorogeneo’ (literally, heterogeneous) and a prologue delivered by one ‘Folletto’, the audience should almost certainly expect to encounter something unexpected...
Jessica Goethals, Eugenio Refini
openaire   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source