Results 101 to 110 of about 1,205,134 (266)

Systematic review and economic modelling of the relative clinical benefit and cost-effectiveness of laparoscopic surgery and robotic surgery for removal of the prostate in men with localised prostate cancer [PDF]

, 2012
PMID: 23127367 [PubMed - indexed for MEDLINE] Free full text Funding for this study was provided by the Health Technology Assessment programme of the National Institute for Health Research.Peer ...
Royle, J., C Robertson, Pickard, R., C Ramsay, Close, A, Jia, X., Fraser, C., Armstrong, N, Royle, J, Rushton, S P, Robertson, C., Ramsay, C, D Jenkinson, Gurung, T, Lam, T B, Mowatt, G, Fraser, C, Neal, D. E., Rushton, S. P., Armstrong, N., Eden, C. G., MC Robinson, Jenkinson, D, Robinson, M. C., CG Eden, Vale, L, Sharma, P., MDF Shirley, DA Barocas, Lam, T. B., Sharma, P, J Royle, Neal, D E, L Vale, Close, A., Barocas, D A, Robinson, M C, A Close, Robertson, C, TB Lam, DE Neal, Ramsay, C. R. (Craig R.), Gurung, T. (Tara), Mowatt, G., C Fraser, Shirley, M D F, SP Rushton, N Armstrong, Pickard, R, Eden, C G, Barocas, D. A., P Sharma, Vale, L. (Luke), Jenkinson, D., T Gurung, R Pickard, Soomro, N., G Mowatt, Shirley, M. D. F., Jia, X, Soomro, N, N Soomro, X Jia   +62 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Advancing environmental exposure assessment science to benefit society

Nature Communications, 2019
How can scientists and policymakers work together to reduce the health impacts of air pollution? In this review paper, the authors discuss the interplay between advances in environmental exposure assessment and policy advances to tackle pollution in a ...
Andrew Caplin, Masoud Ghandehari, Chris Lim, Paul Glimcher, George Thurston   +4 more
doaj   +1 more source

A multi-level cost benefit approach for regulatory decision support in food safety and quality assurance scenarios

In complex policy decision situations where policy objectives can only be reached through appropriate activities of individual actors with own decision authority and individual objectives, the classical approaches for measuring the effects of regulatory ...
Fritz, Melanie, Schiefer, Gerhard
core  

Cost-Benefit Analysis and Regulatory Reform: An Assessment of the Science and Art [PDF]

The continuing efforts in the 104th Congress to legislate requirements for cost-benefit analysis (CBA) and the revised Office of Management and Budget guidelines for the conduct of such assessments during a regulatory rulemaking process highlight the ...
Krupnick, Alan, Kopp, Raymond, Toman, Michael   +2 more
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Development of dietary assessment instruments which can take cultural diversity and dietary acculturation into account: eating in Sweden (‘Mat i Sverige’)

Journal of Nutritional Science
Since lack of culture-specific foods in dietary assessment methods may bias reported dietary intake, we identified foods and dishes consumed by residents not born in Sweden and describe consequences for reported foods and nutrient intake using a ...
Marleen A. H. Lentjes, Sarah Lönnström, Karin Lobenius Palmér, Zeinab Alsammarraie, Anna Karin Lindroos, Jessica Petrelius Sipinen, Afsaneh Koochek, Robert Jan Brummer, Scott Montgomery   +8 more
doaj   +1 more source

The Implications of Cost-Effectiveness Analysis of Medical Technology: Background Paper 3: The Efficacy and Cost Effectiveness of Psychotherapy

, 1980
An background paper for an assessment by the Office of Technology Assessment (OTA) that "emphasizes methodological issues related to the assessment of psychotherapy and the use of cost-effectiveness/cost-benefit analysis (CEA/CBA) to evaluate ...
United States. Congress. Office of Technology Assessment.
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source