Results 101 to 110 of about 8,678,363 (314)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Bulletin of the Transilvania University of Braşov: Series IX Sciences of Human KineticsThe scientific research on using CrossFit in combat sports like judo and sambo lacks evidence, prompting further investigation. This paper aims to analyze existing literature on CrossFit and combat sports.
C. Stanciu, V. Ene-Voiciulescu
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
AgricultureCover crops are becoming widely integrated into many farms as tools for improving sustainability. However, the decisions by growers for planting follow several objectives/criteria, many of which overlap.
Paul Cottney +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Review of implementation of biogas technology in rural communities of South Africa
Cogent Social SciencesEnergy access is vital for socioeconomic development in rural areas, but challenges persist due to unreliable grid power. There are potential solutions in renewable energy technologies, including biogas, but implementation hurdles remain.
Thilivhali Rasimphi +4 more
doaj +1 more source
State support of small business: a modern practice in Russia and abroad
Ученые записки Российской академии предпринимательства, 2021 The article deals with a topical theme of state support of the small business organizations. This article analyzes the system of support activities and small business development in Russia and abroad. Conclusions and proposals to support small businesses
V. B. Frolova, A. K. Margaryan
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
La certification qualité en milieu rural comme moteur de viabilité du tourisme
Téoros, 2020 One of the main pillars of sustainable rural tourism is the economic viability of businesses. The rural quality certification can be an interesting instrument to evaluate it, given that it has positive direct and indirect effects on sustainability, by ...
Francisco Javier de la Ballina +2 more
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