Results 51 to 60 of about 1,921,338 (267)

Long-term prosthesis survival of total hip and total knee arthroplasty in people with inherited bleeding disorders

Research and Practice in Thrombosis and Haemostasis
Background: Joint arthroplasty provides pain relief and functional improvement, but higher peri- and postoperative risks in people with bleeding disorders historically lead to lower prosthesis survival rates (PSRs) than in the general population.
Gijs Aertssen, Huub M. de Visser, Wouter Foppen, Roger E.G. Schutgens, Merel A. Timmer, Lize F.D. van Vulpen   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Three-year safety, efficacy, and renal outcomes of mitapivat treatment in sickle cell disease: results from the phase 2 open-label study

Haematologica
Not available.
Geoffrey Z.L. Kuppens, Maria Armila D. Ruiz, Myrthe J. van Dijk, Minke A.E. Rab, Cleo Derichs, Joline Saes, Anita W. Rijneveld, Marjon H. Cnossen, Erfan Nur, Bart J. Biemond, Marije Bartels, Santosh L. Saraf, Eduard J. van Beers   +12 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Environmentally benign machining

This book provides essential information on environmentally benign/sustainable machining processes including innovations and developments in conventional machining, considering economy, safety, and productivity.
Bayraktar, Şenol, Pathak, Sunil
core   +1 more source

Interobserver agreement of Thyroid Imaging Reporting and Data System (TIRADS) and strain elastography for the assessment of thyroid nodules [PDF]

, 2013
Background: Thyroid Imaging Reporting and Data System (TIRADS) was developed to improve patient management and cost-effectiveness by avoiding unnecessary fine needle aspiration biopsy (FNAB) in patients with thyroid nodules.
Stefan Zeuzem, Herrmann, Eva, Friedrich-Rust, Mireen, Dauth, Nina, Bogdanou, Dimitra, Christian Berner, Nina Dauth, Mireen Friedrich-Rust, Bojunga, Jörg, Dimitra Bogdanou, Joerg Bojunga, Gesine Meyer, Eva Herrmann, Berner, Christian, Meyer, Gesine, Zeuzem, Stefan   +15 more
core   +2 more sources

Vitamin D Insufficiency/Deficiency in Patients with Recurrent Benign Paroxysmal Positional Vertigo

, 2022
Background: The aim of this study is to verify if (1) there is a link between hypovitaminosis D and benign paroxysmal positional vertigo, (2) the number of benign paroxysmal positional vertigo relapses decreases after vitamin D supplementation; and (3 ...
Di Giustino, Fabio, Rossana Santimone, Roberto Bertolai, Paolo Vannucchi, Fabio Di Giustino, Beatrice Giannoni, Santimone, Rossana, Vanni, Simone, Bentivegna, Lisa, Vannucchi, Paolo, Arianna Mengucci, Federica Pollastri, Mandalà, Marco, Bertolai, Roberto, Giannoni, Beatrice, Mengucci, Arianna, Antonella Marcari, Pecci, Rudi, Lisa Bentivegna, Rudi Pecci, Marco Mandalà, Pollastri, Federica, Simone Vanni, Marcari, Antonella   +23 more
core   +1 more source

Gynaecological Perspective of Schwannoma: A Rare Pelvic Tumour [PDF]

Journal of Clinical and Diagnostic Research, 2016
Schwannomas are benign tumours that arise from Schwann cells of nerve fibres. They commonly occur in the head, neck, mediastinum and extremities but pelvic occurrence is rare. We report a rare case of retroperitoneal tumour with Gynaec presentation.
Neranjana Padmanaban, Priya Subash Chandrabose, Muthuvel Esakki, Hephzibah Kirubamani, Chitra Srinivasan   +4 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source