Results 151 to 160 of about 38,481 (291)
Tautomeric Equilibria Studies by Mass Spectrometry [PDF]
, 2008 Tautomerism in organic chemistry has been extensively studied in condensed phase by spectrometric methods, mainly by IR and NMR techniques. Mass spectrometry studies start 40 years ago but just recently it has been recognized the importance of the mass ...
Eduardo A. Castro +3 more
core +1 more source
Design, synthesis and evaluation of novel 3,5-disubstituted benzamide derivatives as allosteric glucokinase activators [PDF]
, 2019 Ajmer Singh Grewal +4 more
openalex +1 more source
Prefrontal TRPM8 Receptor Modulates Epileptic Seizures via PKA/CREB Signaling Pathway in Mice
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.Jia‐zhan Huang et al. describe a function of prefrontal TRPM8 in the regulation of epileptic seizures. TRPM8 receptors was upregulated in the prefrontal cortex (PFC) of epileptic mice. Inhibition or knockdown of TRPM8 in PFC can effectively prolong the latency and reduce the level of seizures in mouse models induced by pentatetrazole. At the same time,
Jia‐Zhan Huang +6 more
wiley +1 more source
Synthesis of N-(3-Methyl-4-Phenyl-3H-Selenazol-2-Ylidene)Benzamide Derivatives [PDF]
, 2018 Sonia Singh +2 more
openalex +1 more source
Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.DCAF7 is up‐regulated in various tumours and correlates with poor prognosis, particularly in LIHC. High DCAF7 expression is linked to CD4+ T cell infiltration, up‐regulation of immune checkpoint genes and increased tumour mutational burden, suggesting a role in tumour immune escape.
Ruina Luan +6 more
wiley +1 more source
Medicinal Research Reviews, Volume 46, Issue 1, Page 203-237, January 2026.ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller +5 more
wiley +1 more source
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management
Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh +4 more
wiley +1 more source
State‐dependent regulation of the Kv7.2 channel voltage sensor by QO‐58
British Journal of Pharmacology, Volume 183, Issue 2, Page 333-348, January 2026.Background and Purpose KV7(KCNQ) potassium channels are key modulators of neuronal excitability, and promising targets for development of drugs for epilepsy and pain. We investigated a candidate KV7 drug, QO‐58, which has been previously described but has an unclear mechanism of action.
Richard Kanyo +3 more
wiley +1 more source
Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale
Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi +4 more
wiley +1 more source