Results 11 to 20 of about 16,778 (193)

Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors

Metabolites, 2018
A series of benzamides incorporating 4-sulfamoyl moieties were obtained by reacting 4-sulfamoyl benzoic acid with primary and secondary amines and amino acids. These sulfonamides were investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA,
Morteza Abdoli, Murat Bozdag, Andrea Angeli, Claudiu T. Supuran   +3 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-N-(pyridin-2-ylmethyl)benzamide

Acta Crystallographica Section E: Crystallographic Communications, 2019
The title compound, C18H18F2N2O3, crystallizes with two independent molecules (A and B) in the asymmetric unit. They differ essentially in the orientation of the pyridine ring with respect to the benzene ring; these two rings are inclined to each other ...
G. Artheswari, V. Maheshwaran, N. Gautham   +2 more
doaj   +1 more source

Structural analysis of 2-iodobenzamide and 2-iodo-N-phenylbenzamide

Acta Crystallographica Section E: Crystallographic Communications, 2018
The title compounds, 2-iodobenzamide, C7H6INO (I), and 2-iodo-N-phenylbenzamide, C13H10INO (II), were both synthesized from 2-iodobenzoic acid. In the crystal structure of (I), N—H...O and hydrogen bonds form two sets of closed rings, generating dimers ...
Keshab M. Bairagi, Vipin B. S. Kumar, Subhrajyoti Bhandary, Katharigatta N. Venugopala, Susanta K. Nayak   +4 more
doaj   +1 more source

Discovery of Indole-Containing Benzamide Derivatives as HDAC1 Inhibitors with In Vitro and In Vivo Antitumor Activities

Pharmaceutical Fronts, 2022
Targeting histone deacetylases (HDACs) has become an important focus in cancer inhibition. The pharmacophore of HDAC inhibitors (HDACis) reported so far is composed of three parts: a zinc-binding group (ZBG), a hydrophobic cavity-binding linker, and a ...
Xiu Gu, Xin-Yan Peng, Hao Zhang, Bo Han, Min-Ru Jiao, Qiu-Shi Chen, Qing-Wei Zhang   +6 more
doaj   +1 more source

The assessment of acute toxicity of 3-[4-(2-fluorobenzoyl)piperazine-1-carbonyl]-N-[3-(trifluoromethyl)-phenyl]benzamide [PDF]

Вестник Витебского государственного медицинского университета, 2022
Objectives. To evaluate the acute toxicity of a benzamide derivative – 3-[4-(2-fluorobenzoyl)piperazine-1-carbonyl]-N-[3-(trifluoromethyl)-phenyl]benzamide after a single intragastric administration to laboratory mice and rats.
O.G. Sechko, V.M. Tsarenkov
doaj   +1 more source

N-(diisopropylphosphanyl)benzamide

Molbank, 2023
N-(diisopropylphosphanyl)benzamide, PhC(O)NHPiPr2, has been synthesized in good yield following two alternative procedures that employ benzamide as the starting material. The first one is a two-step preparation, in which N-(trimetilsilyl)benzamide is reacted with PiPr2Cl, to give the title compound in good yield, whereas the second one is a ...
María M. Alcaide, Daniel García Garrido, Eleuterio Álvarez, Riccardo Peloso   +3 more
openaire   +5 more sources

Chemoenzymatic Synthesis of Well‐Defined α(2,8)‐ and α(2,9)‐Linked Oligosialosides

Angewandte Chemie, EarlyView.
Well‐defined α(2,8)‐ and α(2,9)‐linked oligosialic acids of different lengths can be prepared by employing recombinant bacterial polysialyltransferases in combination with chemically modified CMP‐Neu5Ac derivatives. After transfer, a sialoside is formed bearing an artificial entity, which blocks further glycosylation.
Jelle A. Fok, Keshav Kishor, Mehman I. Bunyatov, Gerlof P. Bosman, Geert‐Jan Boons   +4 more
wiley   +2 more sources

Crystal structure of 2-methyl-N-{[2-(pyridin-2-yl)ethyl]carbamothioyl}benzamide

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C16H17N3OS, a benzoyl thiourea derivative, the planes of the pyridine and benzene rings are inclined to one another by 66.54 (9)°. There is an intramolecular N—H...O hydrogen bond present forming an S(6) ring motif. In the crystal,
Nadiah Ameram, Farook Adam
doaj   +1 more source

Kinetically Stable Boron‐Heteroatom Bonds

Angewandte Chemie, EarlyView.
This study investigates the kinetic stability of boron‐heteroatom bonds in N‐methyliminodiacetic acid (MIDA) boronates. The hemilabile nature of the ligand enables the synthesis of molecules that would otherwise be considered too hydrolytically labile. Depending on the structure, acid‐promoted migration of the boryl group was found to produce compounds
Alina Trofimova, Ben Zhen Huang, Harjeet S. Soor, Brandon White, Aleksandra Holownia, Yury Lebedev, Alan J. Lough, Travis Dudding, Andrei K. Yudin   +8 more
wiley   +2 more sources

5-Amino-2-chloro-4-fluoro-N-(N-isopropyl-N-methylsulfamoyl) benzamide, C11H15O3ClFN3S

Zeitschrift für Kristallographie - New Crystal Structures, 2023
C11H15O3ClFN3S, triclinic, P1‾ $P\overline{1}$ (no. 2), a = 7.8107(11) Å, b = 9.1644(13) Å, c = 11.3521(15) Å, α = 67.543(2)°, β = 72.776(2)∘ $72.776{(2)}^{\circ }$ , γ = 88.529(2)∘ $88.529{(2)}^{\circ }$ , V = 713.76(17) Å3, Z = 2, Rgt ${R}_{\mathit{g}\
Jie Wang, Xiao Shu-Zhen, Cong Huang, Liu Ya-Qiang, Peng Da-Yong   +4 more
doaj   +1 more source