Results 21 to 30 of about 22,537 (233)

Discovery of Indole-Containing Benzamide Derivatives as HDAC1 Inhibitors with In Vitro and In Vivo Antitumor Activities

Pharmaceutical Fronts, 2022
Targeting histone deacetylases (HDACs) has become an important focus in cancer inhibition. The pharmacophore of HDAC inhibitors (HDACis) reported so far is composed of three parts: a zinc-binding group (ZBG), a hydrophobic cavity-binding linker, and a ...
Xiu Gu, Xin-Yan Peng, Hao Zhang, Bo Han, Min-Ru Jiao, Qiu-Shi Chen, Qing-Wei Zhang   +6 more
doaj   +1 more source

Rational Design, Synthesis, Biological Evaluation, and In Silico Study of N-Cinnamamide/Benzamide-(4-(Substituted Phenyl)-6-(4-Cyclohexylphenyl)pyrimidin-2-Yl) Derivatives as EGFR Inhibitors Targeting EGFR^WT, EGFR^T790M, and EGFR^L858R ^/T790M/C797S in NSCLC. [PDF]

Chem Biol Drug Des
Rational Design, Synthesis, Biological Evaluation, and In Silico Investigation of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐yl) Derivatives as EGFR Inhibitors Targeting Wild‐Type and Mutant EGFR in NSCLC. ABSTRACT Non‐small cell lung cancer (NSCLC), driven by mutations in the epidermal growth factor receptor ...
Pal R, Matada GSP, Teli G, Bv M, Moulishankar A, Chawla V, Chawla PA.   +6 more
europepmc   +2 more sources

Exploring the cocrystallization potential of urea and benzamide [PDF]

, 2016
International audienceThe cocrystallization landscape of benzamide and urea interacting with aliphatic and aromatic carboxylic acids was studied both experimentally and theoretically.
Cysewski, Piotr, Przybyłek, Maciej, Mroczyńska, Karina, Ziółkowska, Dorota   +3 more
core   +1 more source

Structural analysis of 2-iodobenzamide and 2-iodo-N-phenylbenzamide

Acta Crystallographica Section E: Crystallographic Communications, 2018
The title compounds, 2-iodobenzamide, C7H6INO (I), and 2-iodo-N-phenylbenzamide, C13H10INO (II), were both synthesized from 2-iodobenzoic acid. In the crystal structure of (I), N—H...O and hydrogen bonds form two sets of closed rings, generating dimers ...
Keshab M. Bairagi, Vipin B. S. Kumar, Subhrajyoti Bhandary, Katharigatta N. Venugopala, Susanta K. Nayak   +4 more
doaj   +1 more source

The assessment of acute toxicity of 3-[4-(2-fluorobenzoyl)piperazine-1-carbonyl]-N-[3-(trifluoromethyl)-phenyl]benzamide [PDF]

Вестник Витебского государственного медицинского университета, 2022
Objectives. To evaluate the acute toxicity of a benzamide derivative – 3-[4-(2-fluorobenzoyl)piperazine-1-carbonyl]-N-[3-(trifluoromethyl)-phenyl]benzamide after a single intragastric administration to laboratory mice and rats.
O.G. Sechko, V.M. Tsarenkov
doaj   +1 more source

Crystal structure of 2-methyl-N-{[2-(pyridin-2-yl)ethyl]carbamothioyl}benzamide

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C16H17N3OS, a benzoyl thiourea derivative, the planes of the pyridine and benzene rings are inclined to one another by 66.54 (9)°. There is an intramolecular N—H...O hydrogen bond present forming an S(6) ring motif. In the crystal,
Nadiah Ameram, Farook Adam
doaj   +1 more source

3,5-Dibromo-4-carbamoylbenzoic acid 2-propanol monosolvate

IUCrData, 2021
In the title solvated crystal, C8H5Br2NO3·C3H8O, the acid molecules form inversion dimers by pairwise N—H...O hydrogen bonds between carbamoyl groups and the carboxyl and carbamoyl groups link to form head-to-tail inversion dimers.
Wayland E. Noland, Ryan J. Herzig, Renee J. Fox, Kenneth J. Tritch   +3 more
doaj   +1 more source

Crystal structure of 3-chloro-N-(2-nitrophenyl)benzamide

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C13H9ClN2O3, the mean plane of the central amide fragment (r.m.s. deviation = 0.016 Å) subtends dihedral angles of 15.2 (2) and 8.2 (2)° with the chloro- and nitro-substituted benzene rings, respectively.
Rodolfo Moreno-Fuquen, Alexis Azcárate, Alan R. Kennedy   +2 more
doaj   +1 more source

New N-acyl Thiourea Derivatives: Synthesis, Standardized Quantification Method and In Vitro Evaluation of Potential Biological Activities

Antibiotics, 2023
New N-acyl thiourea derivatives with heterocyclic rings have been synthesized by first obtaining isothiocyanate, which further reacted with a heterocyclic amine, characterized by (FT-IR, NMR spectroscopy and FT-ICR) and tested for their in vitro ...
Roxana Roman, Lucia Pintilie, Miron Teodor Căproiu, Florea Dumitrașcu, Diana Camelia Nuță, Irina Zarafu, Petre Ioniță, Mariana Carmen Chifiriuc, Cornel Chiriță, Alina Moroșan, Marcela Popa, Coralia Bleotu, Carmen Limban   +12 more
doaj   +1 more source

Study of the reactivity of aminocyanopyrazoles and evaluation of the mitochondrial reductive function of some products

Heterocyclic Communications, 2022
This research investigated the general high-throughput synthetic protocol for the accelerated synthesis of functionalized trifluoromethylpyrazolopyrimidines 3 and N-(5-cyano-3-methyl-1-phenyl-1H-pyrazol-4-yl) benzamide 4 from aminocyanopyrazole 1 ...
Bellili Soumaya, Coltman Nicholas J., Hodges Nikolas J., Allouche Fatma   +3 more
doaj   +1 more source