Results 61 to 70 of about 20,936 (236)

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Making Benzamide Cocrystals with Benzoic Acids: The Influence of Chemical Structure.

, 2016
An investigation into the creation of cocrystals of benzamide and substituted benzoic acids was undertaken and four new cocrystals were structurally characterized by single-crystal X-ray diffraction.
Andrew Parkin (1995427), Colin C. Seaton (1364412)   +1 more
core   +2 more sources

2-Anilino-N-methyl-N-phenylbenzamide

Acta Crystallographica Section E, 2009
The title compound, C20H18N2O, is composed of three aromatic rings, the dihedral angles between the phenyl and benzamide rings, and between the benzamide and aniline rings being 59.86 (9) and 46.57 (10)°, respectively.
Da-Bin Qin, Chenglin Zhou, Xing-Xing Yang   +2 more
doaj   +1 more source

Pharmacological evaluation of novel bioisosteres of an adamantanyl benzamide P2X7 receptor antagonist [PDF]

, 2017
Adamantanyl benzamide 1 was identified as a potent P2X7R antagonist but failed to progress further due to poor metabolic stability. We describe the synthesis and SAR of a series of bioisosteres of benzamide 1 to explore improvements in the ...
Windhorst, Albert D., Kristen K. Skarratt, James O’Brien-Brown, Janssen, Bieneke, O'Brien-Brown, James, Barron, Melissa L, Skarratt, Kristen K., Mansoor Chishty, Fuller, Stephen, Ong, Jennifer A., Werry, Eryn L., Albert D. Windhorst, Kassiou, Michael, Stephen Fuller, Michael Kassiou, Wilkinson, Shane M, Skarratt, Kristen K, Shane M. Wilkinson, Danielle J. Vugts, Vugts, Danielle J., Hibbs, David E, Wilkinson, Shane M., Hibbs, David E., Eryn L. Werry, Vugts, Danielle J, Windhorst, Albert D, David E. Hibbs, Melissa L. Barron, Barron, Melissa L., Bieneke Janssen, Werry, Eryn L, Stokes, Leanne, Ong, Jennifer A, Chishty, Mansoor, Leanne Stokes, Jennifer A. Ong   +35 more
core   +2 more sources

Crystal structure of 2-(1,3,7,9-tetramethyl-2,4,6,8-tetraoxo-1,2,3,4,6,7,8,9-octahydropyrido[2,3-d:6,5-d′]dipyrimidin-5-yl)benzamide dimethylformamide hemisolvate

Acta Crystallographica Section E, 2014
The title compound, C20H18N6O5·0.5C3H7NO, crystallized as a dimethylformamide (DMF) solvate. In the main molecule, the dihedral angle between the pyridodipyrimidine fused-ring system and the benzamide substituent is 82.26 (11)°.
Armen Ayvazyan
doaj   +1 more source

Exploring the cocrystallization potential of urea and benzamide

, 2016
International audienceThe cocrystallization landscape of benzamide and urea interacting with aliphatic and aromatic carboxylic acids was studied both experimentally and theoretically.
Cysewski, Piotr, Przybyłek, Maciej, Mroczyńska, Karina, Ziółkowska, Dorota   +3 more
core   +1 more source

Synthesis of telechelic poly(p-benzamide)s [PDF]

, 2018
Well-defined telechelic poly(benzamide)s were synthesized by chain-growth polycondensation of phenyl-4-amino benzoate and pentafluorophenyl-4-amino benzoate derivatives with a bifunctional initiator in the presence of LiTMP as base. The polymerization
Mahshid Alizadeh, Andreas F.M. Kilbinger, Kilbinger, Andreas F. M., Andreas F. M. Kilbinger, Alizadeh, Mahshid   +4 more
core   +1 more source

Katalysatoraktivierung als Schlüsselfaktor in Kreuzkupplungen: Raumtemperatur‐Kupplungen schwacher Nukleophile ermöglicht durch [Pd(1‐MeNAP)TFA]2 Präkatalysatoren

Angewandte Chemie, EarlyView.
Bei vielen Pd‐katalysierten Kreuzkupplungen hat sich gezeigt, dass die Katalysatorleistung durch dessen Aktivierung begrenzt wird. Methylnaphthyl (MeNAP)‐Palladiumtrifluoracetat‐Dimere werden als leicht zu lagernde und handhabende Präkatalysatoren vorgestellt, die sich unter Reaktionsbedingungen schnell aktivieren, selbst wenn nur schwach ...
Sourav Manna, Henric F. Janning, Nikolaos V. Tzouras, Jane Anto Simplica Sagayaraj, Fadil Faizal Mannighayil, Angelino Doppiu, Lukas J. Gooßen   +6 more
wiley   +1 more source

Novas N-benzoiltiraminas de Swinglea glutinosa (Rutaceae)

Química Nova, 2012
Phytochemical studies of the leaves and fruits have led to the identification of the known amides (E)-N-methyl-cinnamamide, N-benzoyltyramine, N-benzoyl-O-geranyltyramine, N-benzoyl-O-(4-acetoxyl)-geranyltyramine, in addition to the new N-{2-[4-(butoxyl ...
Cristovam do Nascimento Cerqueira, Djalma A. P. dos Santos, Karla da Silva Malaquias, Murilo Marinho de Castro Lima, Maria Fátima das Graças Fernandes da Silva, João Batista Fernandes, Paulo Cezar Vieira   +6 more
doaj   +1 more source

Borylated 2,3,4,5-Tetrachlorophthalimide and Their 2,3,4,5-Tetrachlorobenzamide Analogues: Synthesis, Their Glycosidase Inhibition and Anticancer Properties in View to Boron Neutron Capture Therapy

Molecules, 2022
Tetrachlorinated phthalimide analogues bearing a boron-pinacolate ester group were synthesised via two synthetic routes and evaluated in their glycosidase modulating and anticancer properties, with a view to use them in boron neutron capture therapy ...
David M. Campkin, Yuna Shimadate, Barbara Bartholomew, Paul V. Bernhardt, Robert J. Nash, Jennette A. Sakoff, Atsushi Kato, Michela I. Simone   +7 more
doaj   +1 more source