Results 81 to 90 of about 22,537 (233)

Comprehensive analysis of microtubule‐inhibiting herbicides reveals shared subcellular phenotypes and distinct resistance profiles

Pest Management Science, EarlyView.
Using cellular phenotyping and resistance profiling, we show that herbicides across the Herbicide Resistance Action Committee (HRAC) Groups 3 and 23 induce indistinguishable, dose‐dependent microtubule defects. Resistance patterns, rather than cellular phenotypes, reveal distinct sites of action and support reclassifying Group 3 as α‐tubulin binders ...
Katharina Kaprocki, Jennifer Blau, Michael Betz, Jessica Knox, Jens Lerchl, Philipp Johnen, Selene Garcia‐Hernandez   +6 more
wiley   +1 more source

Pharmacological evaluation of novel bioisosteres of an adamantanyl benzamide P2X7 receptor antagonist [PDF]

, 2017
Adamantanyl benzamide 1 was identified as a potent P2X7R antagonist but failed to progress further due to poor metabolic stability. We describe the synthesis and SAR of a series of bioisosteres of benzamide 1 to explore improvements in the ...
Windhorst, Albert D., Kristen K. Skarratt, James O’Brien-Brown, Janssen, Bieneke, O'Brien-Brown, James, Barron, Melissa L, Skarratt, Kristen K., Mansoor Chishty, Fuller, Stephen, Ong, Jennifer A., Werry, Eryn L., Albert D. Windhorst, Kassiou, Michael, Stephen Fuller, Michael Kassiou, Wilkinson, Shane M, Skarratt, Kristen K, Shane M. Wilkinson, Danielle J. Vugts, Vugts, Danielle J., Hibbs, David E, Wilkinson, Shane M., Hibbs, David E., Eryn L. Werry, Vugts, Danielle J, Windhorst, Albert D, David E. Hibbs, Melissa L. Barron, Barron, Melissa L., Bieneke Janssen, Werry, Eryn L, Stokes, Leanne, Ong, Jennifer A, Chishty, Mansoor, Leanne Stokes, Jennifer A. Ong   +35 more
core   +2 more sources

Kinetically Stable Boron‐Heteroatom Bonds

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
This study investigates the kinetic stability of boron‐heteroatom bonds in N‐methyliminodiacetic acid (MIDA) boronates. The hemilabile nature of the ligand enables the synthesis of molecules that would otherwise be considered too hydrolytically labile. Depending on the structure, acid‐promoted migration of the boryl group was found to produce compounds
Alina Trofimova, Ben Zhen Huang, Harjeet S. Soor, Brandon White, Aleksandra Holownia, Yury Lebedev, Alan J. Lough, Travis Dudding, Andrei K. Yudin   +8 more
wiley   +2 more sources

Discovery and characterisation of succinate dehydrogenase inhibitor resistance in Plenodomus biglobosus (phoma stem canker of oilseed rape)

Pest Management Science, EarlyView.
SDHI resistance is reported and characterised for the first time in the oilseed rape phoma stem canker pathogen Plenodomus biglobosus (Leptosphaeria biglobosa). We investigate cross‐resistance patterns, associated SDH target‐site mutations, possible fitness costs, and consider the implications for disease and resistance management.
Kevin M King, Jonathan S West
wiley   +1 more source

Crystal structures of three 3,4,5-trimethoxybenzamide-based derivatives

Acta Crystallographica Section E: Crystallographic Communications, 2016
The crystal structures of three benzamide derivatives, viz. N-(6-hydroxyhexyl)-3,4,5-trimethoxybenzamide, C16H25NO5, (1), N-(6-anilinohexyl)-3,4,5-trimethoxybenzamide, C22H30N2O4, (2), and N-(6,6-diethoxyhexyl)-3,4,5-trimethoxybenzamide, C20H33NO6, (3 ...
Ligia R. Gomes, John Nicolson Low, Catarina Oliveira, Fernando Cagide, Fernanda Borges   +4 more
doaj   +1 more source

Revisiting small‐molecule fluorescent probes in food freshness detection

Smart Molecules, EarlyView.
Fluorescent probes serve as versatile tools for food freshness monitoring. This review summarizes recent advances in probes targeting biogenic amines, hydrogen sulfide, pH values, and other key spoilage markers, highlighting their design principles, sensing mechanisms, and practical applications in food quality monitoring. Abstract Food spoilage driven
Xinrui Wang, Zhao Wang, Jingwen Zou, Xuyuan Jiang, Changyu Bian, Zhiqiang Mao   +5 more
wiley   +1 more source

N-(4-iodophenyl)benzamide

, 2018
This dataset contains experimental data from a sample (N-(4-iodophenyl)benzamide, InChI=1S/C13H10INO/c14-11-6-8-12(9-7-11)15-13(16)10-4-2-1-3-5-10/h1-9H,(H,15,16)). The datasets from the following experiments are available: 1H nuclear
Wippert, Nicolai
core   +1 more source

Crystal structure of 4-chloro-N-{[1-(4-chlorobenzoyl)piperidin-4-yl]methyl}benzamide monohydrate

Acta Crystallographica Section E, 2014
In the title compound, C20H20Cl2N2O2·H2O, the piperidine ring adopts a chair conformation with the two substituent benzene rings inclined to one another [dihedral angle 84.63 (9)°].
K. Prathebha, D. Reuben Jonathan, S. Sathya, J. Jovita, G. Usha   +4 more
doaj   +1 more source

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

Smart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin, Meng‐Di Chen, Wenqi Gao, Yiping Wang, Lin‐Qing Liu, Zhen Teng, Tienan Qi, Qiyuan Wang, Yuxuan Wang, Daoxiang Li, Keqiang Yan, Ling Pan, Zhongwei Zhao, Shuo Zhao, Kang‐Nan Wang, Shuai Fu, Nengwang Yu   +16 more
wiley   +1 more source

2-Chloro-N-[N-(4-chlorobenzoyl)hydrazinocarbothioyl]benzamide

, 2004
The title compound, C15H11Cl2N 3O2S, has a similar structure and similar structural dimensions to the unsubstituted N-(N-benzoylhydrazinocarbothioyl)benzamide. However, the presence of Cl atoms at the para and ortho positions in the benzamide and benzoyl
Sahali Mardi, A., Ali, Hapipah Mohd, Yamin, B.M., Khamis, N.A., Sukeri Yusof, M.   +4 more
core   +2 more sources