Results 81 to 90 of about 16,778 (193)

Molecular Hybridization of Clinically Relevant P2X7 Antagonists

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
We employed a molecular hybridization strategy, combining clinically validated antagonists AZD‐9056 and JNJ‐54175446, to design and synthesize a library of novel adamantane‐containing P2X7R antagonists. Pharmacological and in silico analyses indicate that these adamantyl hybrids adopt a distinct, shallow binding mode within the P2X7R allosteric pocket,
Nicholas B. Lynch, Charleigh T. A. Agius, André D. J. McKenzie, Jessica O’Driscoll, Angus Tolmie, Taylor R. Garrett, Eryn Werry, Michael Kassiou   +7 more
wiley   +1 more source

Direct Synthesis of 2-(4-Hydroxyphenoxy)benzamide Derivatives from 2-Aryloxybenzamide via PhIO-Mediated Oxidation Reaction

Molecules
The 2-(4-hydroxyphenoxy)benzamide scaffold is frequently found in a variety of bioactive compounds, displaying a broad spectrum of properties, such as antibacterial and antitumor effects.
Zhenhua Shang, Dechen Jiao, Haoran Cheng, Daowei Huang   +3 more
doaj   +1 more source

Structural Modification and Development of <i>N</i>-(1,2,3,4-Tetrahydro-3-isoquinolinylmethyl)benzamide, BPR1M492, as a Potent and Rapid-Onset Opioid Analgesic with Reduced Withdrawal Symptoms. [PDF]

J Med Chem
Chang PW, Chang YC, Tien YW, Chang HF, Chen SR, Chen YP, Huang WC, Hsieh CC, Chang L, Zhuang H, Yeh TK, Tung CW, Yeh SH, Ueng SH.   +13 more
europepmc   +1 more source

Zinc Affinity of Benzamide-Based Histone Deacetylase Inhibitors: A DFT Study. [PDF]

Molecules
Toshev N, Velichkov K, Uzunova Y, Cheshmedzhieva D, Dudev T.   +4 more
europepmc   +1 more source

Structure Merging Approach Leads to New Dual Potent and Selective USP25/USP28 Inhibitors. [PDF]

J Med Chem
Hernandez-Olmos V, Patzke JV, Stone CE, Nair RK, Weller K, Sauer F, Endres E, Jamai O, Rachor L, Warmutz CH, Schwalm MP, Mitrovic M, Grenier V, Ehrler JHM, Proschak A, Heering J, Sotriffer C, Mulder MPC, Knapp S, Kisker C, Proschak E.   +20 more
europepmc   +1 more source

Nickel-Catalyzed Aminocarbonylation of Aryl Trifluoromethoxides. [PDF]

Org Lett
Liu ZW, Kuai CS, Wu XF.
europepmc   +1 more source

The XylC-mediated aromatic metabolic network modulates the metabolic response of Pseudomonas aeruginosa to deltamethrin. [PDF]

BMC Microbiol
Wei X, Zhao X.
europepmc   +1 more source

Do Amino-Oxetanes Resemble Amides? A Matched Molecular Pairs Property and Structural Comparison. [PDF]

J Med Chem
Ishikura H, Begg CS, Rojas JJ, Blagojevic L, Smith GJ, Luk J, Croft RA, Romain C, Choi C, Bull JA.   +9 more
europepmc   +1 more source

Crystal structure and Hirshfeld surface analysis of saflufenacil. [PDF]

Acta Crystallogr E Crystallogr Commun
Liu J.
europepmc   +1 more source

Enhancing Veliparib PARP1 inhibitor stability against UVC degradation <i>via</i> DPPG liposome encapsulation. [PDF]

RSC Adv
Conceição CJF, Moe E, Ribeiro PA, Raposo M.   +3 more
europepmc   +1 more source