Results 101 to 110 of about 20,936 (236)

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Nickel Photocatalytic Access to β‐Arylated β‐Amino Acids

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
Converting naturally abundant amino acids to non‐canonical derivatives in one step under mild conditions allows for improved pharmaceutical properties. Now, this is achieved for β‐arylated β‐amino acids, which are available in good yields directly from aspartic acid, and have the potential to become platform chemicals for drug discovery.
Tim S. Stamp, Ning Wei, Laura K. C. Zedelmair, Sebastian B. Beil   +3 more
wiley   +1 more source

Strategies Toward Accessing Enantioenriched (Hetero)Benzo‐Fused 5‐ and 6‐ Membered Rings via Intermolecular Carbometalation

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The use of transition‐metal catalysts and design of chiral ligands have allowed chemists to access highly functionalized benzofused 5‐ and 6‐ membered rings in high yield and enantioselectivity. A common strategy used relies on an intermolecular carbometalation across alkynes and olefins, usually followed by a subsequent intramolecular carbometalation.
Clara Jans, Armaan Grewal, Xavier Abel‐Snape, Mark Lautens   +3 more
wiley   +2 more sources

Benzamide coordination compounds of magnesium nicotinate

, 2019
The synthesis of benzamide coordination compounds of magnesium nicotinate by a mechanochemical method was carried out. The optimal component ratios and the time of the reactions were established.
Мavluda, Ibragimova, Тursunoy, Ibadullayeva   +1 more
core  

Structure‐Based Design, Synthesis, and Evaluation of Novel Ponatinib Derivatives With a Significantly Altered Selectivity Profile

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
We developed new derivatives of the cancer drug ponatinib, significantly reducing and altering its spectrum of target kinases. Compound 5 retained the efficacy in inhibiting the colony formation of MDA‐MB‐231 cells and acted primarily on B‐Raf and Flt‐1 as its main targets in a kinase panel.
Tobias Betzholz, Ting Liu, Andreas Krämer, Verena Dederer, Stefan Knapp, Sebastian Mathea, Christian Ducho, Matthias Engel   +7 more
wiley   +1 more source

Synthesis of novel substituted N-aryl benzamides as hA3G stabilizers and their inhibitory activities against hepatitis C virus replication

Acta Pharmaceutica Sinica B, 2013
A series of novel amino-substituted N-aryl benzamide analogs were synthesized and evaluated for their ability to inhibit hepatitis C virus (HCV) replication in acutely infected Huh7.5 cells.
Yanping Li, Zonggen Peng, Lanhu Hao, Zhouyi Wu, Yanping Zhu, Laixing Hu, Jiandong Jiang, Zhuorong Li   +7 more
doaj   +1 more source

2-Chloro-N-[N-(4-chlorobenzoyl)hydrazinocarbothioyl]benzamide

, 2004
The title compound, C15H11Cl2N 3O2S, has a similar structure and similar structural dimensions to the unsubstituted N-(N-benzoylhydrazinocarbothioyl)benzamide. However, the presence of Cl atoms at the para and ortho positions in the benzamide and benzoyl
Sahali Mardi, A., Ali, Hapipah Mohd, Yamin, B.M., Khamis, N.A., Sukeri Yusof, M.   +4 more
core   +1 more source

Crystal structures of isomeric 4-bromo-N-[(2-nitrophenyl)sulfonyl]benzamide and 4-bromo-N-[(4-nitrophenyl)sulfonyl]benzamide [PDF]

, 2017
The syntheses and crystal structures of the isomeric 4-bromo-N-[(2-nitrophenyl)sulfonyl]benzamide, (I), and 4-bromo-N-[(4-nitrophenyl)sulfonyl]benzamide, (II), are described (molecular formula = C13H9BrN2O5S in each case).
P. A. Suchetan, Naveen, S., A. G. Sudha, Suresha, E., S. Naveen, Abdoh, Muneer, Suchetan, P. A., M. Abdoh, Lokanath, N. K., N. K. Lokanath, E. Suresha, Sudha, A. G.   +11 more
core   +1 more source

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source

The structures of the two administered compounds (compound 1; 4-(phenylethynyl)-N-[(2-sulfamoylphenyl)sulfonyl]benzamide, compound 2; 4-(cyclobutylethynyl)-N-[(2-sulfamoylphenyl)sulfonyl] benzamide), and their common metabolite bisulphonamide (benzene-1,2-disulphonamide).

, 2012
The structures of the two administered compounds (compound 1; 4-(phenylethynyl)-N-[(2-sulfamoylphenyl)sulfonyl]benzamide, compound 2; 4-(cyclobutylethynyl)-N-[(2-sulfamoylphenyl)sulfonyl] benzamide), and their common metabolite bisulphonamide (benzene-1 ...
Johan Lindberg (18863), Sivert Bjurström (125953), Elisa Basmaci (125960), Richard J. A. Goodwin (125957), Ingela Gustafsson (125964), Benita Forngren (125949), Alexander Svanhagen (125970), Anna Nilsson (125945), Anita Annas (125966), Dennis Hellgren (125968), Per E. Andrén (39579)   +10 more
core   +1 more source