Results 41 to 50 of about 12,797 (181)

Management of trypanosomiasis and leishmaniasis [PDF]

, 2012
<p>Background: The current treatments for human African trypanosomiasis (HAT), Chagas disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are far from ideal but, for some, there has been significant recent progress ...
Alsford, Alvar, Alvar, Barrett, Barrett, Ben Salah, Berman, Bern, Brun, Brun, Burri, Chappuis, Coura, Croft, Croft, El-Sayed, Frearson, Hailu, Jacobs, Jacobs, Le Loup, Lessa, M. P. Barrett, Miranda-Verastegui, Paine, Pinazo, Priotto, Rassi, Reithinger, Rodgers, S. L. Croft, Stuart, Sundar, Sundar, Sundar, Sundar, Torreele, Vanhollebeke, Vincent, Voogd   +39 more
core   +2 more sources

Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins

Química Nova, 2011
This study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were obtained in solution, presenting 1:1
José Lamartine Soares Sobrinho, Mônica Felts de La Roca Soares, Juan Jose Torres Labandeira, Lariza Darlene Santos Alves, Pedro José Rolim Neto   +4 more
doaj   +1 more source

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie International Edition, EarlyView.
A gram‐scale supply of bulbiferamide A, which features a rare N‐acylindole linkage and possesses potent inhibitory activity against Trypanosoma cruzi epimastigotes (IC50 = 4.1 µM)—the causative parasite of Chagas disease—was successfully achieved. Moreover, the cyclization strategy developed in this study facilitated the synthesis of noncanonical ...
Jie Zhang, Hugh Nakamura
wiley   +1 more source

Impact of migration on the occurrence of new cases of Chagas disease in Buenos Aires city, Argentina [PDF]

, 2013
Chagas disease, also known as American Trypanosomiasis, is endemic in the Americas, especially Central and South America. Chagas disease is a zoonotic disease caused by the parasite Trypanosoma cruzi.
Altcheh, Jaime Marcelo, Ballering, Griselda, Berenstein, Ada, Biancardi, Miguel Angel, Espejo Cozzi, Andres, Freillij, Hector, Garcia Bournissen, Facundo, Hernandez, Susana, Moroni, Samanta, Moscatelli, Guillermo, Schwarcz, Marta, Siniawski, Susana, Tarlovsky, Ana   +12 more
core   +2 more sources

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe, Vishal Satikuvar, Tanjia M. Syeda, Monica Cal, Pascal Mäser, Marcel Kaiser, Hachemi Kadri   +6 more
wiley   +1 more source

In vitro and in vivo experimental models for drug screening and development for Chagas disease

Memorias do Instituto Oswaldo Cruz, 2010
Chagas disease, a neglected illness, affects nearly 12-14 million people in endemic areas of Latin America. Although the occurrence of acute cases sharply has declined due to Southern Cone Initiative efforts to control vector transmission, there still ...
Alvaro José Romanha, Solange Lisboa de Castro, Maria de Nazaré Correia Soeiro, Joseli Lannes-Vieira, Isabela Ribeiro, André Talvani, Bernadette Bourdin, Bethania Blum, Bianca Olivieri, Carlos Zani, Carmenza Spadafora, Egler Chiari, Eric Chatelain, Gabriela Chaves, José Eduardo Calzada, Juan Manuel Bustamante, Lucio H Freitas-Junior, Luz I Romero, Maria Terezinha Bahia, Michel Lotrowska, Milena Soares, Sonia Gumes Andrade, Tanya Armstrong, Wim Degrave, Zilton de Araújo Andrade   +24 more
doaj   +1 more source

Solid Nanomedicines of Nifurtimox and Benznidazole for the Oral Treatment of Chagas Disease

Pharmaceutics, 2022
Chagas disease (CD) is a parasitic zoonosis endemic in Central and South America affecting nearly 10 million people, with 100 million people at high risk of contracting the disease.
Miriam Rolon, Eustine Hanna, Celeste Vega, Cathia Coronel, Maria Auxiliadora Dea-Ayuela, Dolores R. Serrano, Aikaterini Lalatsa   +6 more
doaj   +1 more source

Repurposing of Inhibitors of Plasmodial Aspartate Transcarbamoylase Toward Trypanosoma Cruzi

ChemMedChem, Volume 21, Issue 6, 27 March 2026.
Aspartate transcarbamoylase (ATC) catalyzes the committed and rate‐limiting step in the pyrimidine de novo biosynthesis pathway. While previously suggested to be a potential target for antimalarial, antitubercular, and antioncologic drug discovery, we hypothesized that an existing compound library of ATC inhibitors designed from one scaffold by ...
Siyao Chen, Monica Cal, Queenie Mondile, Rick Oerlemans, Mukim Mayur Shashikant, Alexander S. S. Dömling, Özlem Tastan Bishop, Pascal Mäser, Matthew R. Groves   +8 more
wiley   +1 more source

Anti-Trypanosoma cruzi action of a new benzofuran derivative based on amiodarone structure [PDF]

, 2018
Chagas disease is a neglected tropical affection caused by the protozoan parasite Trypanosoma cruzi. There is no current effective treatment since the only two available drugs have a limited efficacy and produce side effects.
Benaim, Gustavo, Hejchman, Elżbieta, Hernández Rodríguez, Vanessa, Pinto Martinez, Andrea, Rodríguez Durán, Jessica Jenireth   +4 more
core   +1 more source

From Synthesis to Therapeutics: Bioactive‐Coated Zein Nanoparticles in Drug Delivery

Biopolymers, Volume 117, Issue 2, March 2026.
ABSTRACT Polymeric zein nanoparticles (ZNP), derived from corn protein, are biodegradable drug carriers with high stability and low synthesis costs. Their amphiphilic nature allows efficient encapsulation of both hydrophilic and lipophilic drugs, making them promising for drug delivery.
Milena Ferreira de Lima, Andy Joel Taipe Huisa, Azael da Silva Neto, Clarice Beatriz Gonçalves Silva, Iago Dillion Lima Cavalcanti, Karolliny Barbosa de Araújo, Mariane Cajubá de Britto Lira‐Nogueira, Nereide Stela Santos Magalhães, Priscila Gubert   +8 more
wiley   +1 more source