Results 51 to 60 of about 12,797 (181)

Comparisons between Crystallography Data and Theoretical Parameters and the Formation of Intramolecular Hydrogen Bonds: Benznidazole

Crystals, 2016
The conformational preferences of benznidazole were examined through the application of DFT, PCM and QTAIM calculations, whose results were compared with crystallography data.
Boaz G. Oliveira, Edilson B. Alencar Filho, Mário L. A. A. Vasconcellos   +2 more
doaj   +1 more source

Review of Chagas Disease and Treatment Obstacles to Eradication [PDF]

, 2019
The World Health Organization and the Center for Disease Control reports Chagas disease, or American trypanosomiasis, as a major neglected tropical disease prevalent in 21 endemic Latin American countries.
Sherman, Emily
core   +1 more source

Molecular diagnosis and typing of Trypanosoma cruzi populations and lineages in cerebral Chagas disease in a patient with AIDS [PDF]

, 2005
Trypanosoma cruzi DNA was amplified from an intracranial biopsy and peripheral blood of an HIV patient with encephalitis; this episode was indicative of AIDS and congenital Chagas disease.
Altcheh, Jaime Marcelo, Begher, Sandra B., Bergher, Sandra B., Bisio, Margarita María Catalina, Burgos, Juan Miguel, Burgos, Juan Miguel, Deccarlini, Florencia, Duffy, Tomás, Freilij, Hector León, Freitas, Jorge M., Levalle, Jorge, Levin, Mariano Jorge, Lopez Alcoba, Horacio, Macedo, Andrea M., Schijman, Alejandro Gabriel, Teijeiro, Ricardo   +15 more
core   +1 more source

From Redox Imbalance to Tissue Injury: Insights Into Antidepressant Drug Amitriptyline Effects on Salivary Glands

Cell Biochemistry and Function, Volume 44, Issue 3, March 2026.
ABSTRACT This study aimed to investigate the effects of amitriptyline administration on the salivary glands and saliva of rats. Twenty‐eight male Wistar rats (60 days old) were divided into two groups (n = 14 per group): control and amitriptyline‐treated (10 mg/kg/day for 30 days).
Cristian dos Santos Pereira, Deiweson Souza‐Monteiro, Yago Gecy de Sousa Né, Jorddy Neves da Cruz, Vinicius Ruan Neves dos Santos, Everton Luiz Pompeu Varela, Sandro Percário, Leonardo Oliveira Bittencourt, Antonio Hernandes Chaves‐Neto, Rafael Rodrigues Lima   +9 more
wiley   +1 more source

Longitudinal study of patients with chronic Chagas cardiomyopathy in Brazil (SaMi-Trop project): a cohort profile. [PDF]

, 2016
PurposeWe have established a prospective cohort of 1959 patients with chronic Chagas cardiomyopathy to evaluate if a clinical prediction rule based on ECG, brain natriuretic peptide (BNP) levels, and other biomarkers can be useful in clinical practice ...
Bierrenbach, Ana Luiza, Cardoso, Clareci Silva, Cunha-Neto, Edécio, de Oliveira, Lea Campos, Ferreira, Ariela Mota, Ferreira, João Eduardo, Haikal, Desirée Sant'Ana, Oliveira, Claudia Di Lorenzo, Reingold, Arthur L, Ribeiro, Antonio Luiz P, Sabino, Ester Cerdeira   +10 more
core   +3 more sources

Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias

Revista da Sociedade Brasileira de Medicina Tropical, 2003
Benznidazole is recommended in Brazil for the treatment of Trypanosoma cruzi infection in acute and early chronic phases of Chagas' disease. Observations by others have indicated a higher incidence of neoplasias in immunosuppressed patients, presenting ...
Sonia G. Andrade, Igor Marcelo Oliveira Mesquita, Jamile F. Jambeiro, Isis F. Magalhães Santos, Renata Siqueira Portella   +4 more
doaj  

Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans

Memorias do Instituto Oswaldo Cruz, 2005
Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were
Edilson N Kaneshima, Marialba A Alves de Castro-Prado   +1 more
doaj   +1 more source

Short-term follow-up of chagasic patients after benznidazole treatment using multiple serological markers [PDF]

, 2011
Background Conventional serological tests, using total soluble proteins or a cocktail of recombinant proteins from T. cruzi as antigens, are highly sensitive for Chagas disease diagnosis.
Ana Fernández-Villegas, María Jesús Pinazo, Concepción Marañón, M Carmen Thomas, Elizabeth Posada, Bartolomé Carrilero, Manuel Segovia, Joaquim Gascon, Manuel C López   +8 more
core   +1 more source

Artificial intelligence‐powered microscopy: Transforming the landscape of parasitology

Journal of Microscopy, Volume 301, Issue 2, Page 280-329, February 2026.
Abstract Microscopy and image analysis play a vital role in parasitology research; they are critical for identifying parasitic organisms and elucidating their complex life cycles. Despite major advancements in imaging and analysis, several challenges remain. These include the integration of interdisciplinary data; information derived from various model
Mariana De Niz, Sara Silva Pereira, David Kirchenbuechler, Leandro Lemgruber, Constadina Arvanitis   +4 more
wiley   +1 more source

Clinical and laboratory status of patients with chronic Chagas disease living in a vector-controlled area in Minas Gerais, Brazil, before and nine years after aetiological treatment

Memorias do Instituto Oswaldo Cruz, 2009
Twenty-eight Chagas disease patients (CD), 22 with the indeterminate clinical form (IND) and six with the cardiac or digestive form (CARD/DIG), were treated with benznidazole and underwent clinical and laboratorial analysis before (IND and CARD/DIG) and ...
Marta de Lana, Leonardo A Lopes, Helen R Martins, Maria T Bahia, Girley F Machado-de-Assis, Ana P Wendling, Olindo A Martins-Filho, Roberto A Montoya, João CP Dias, Pedro Albajar-Viñas, José R Coura   +10 more
doaj   +1 more source