Results 51 to 60 of about 12,752 (178)

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source

Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias

Revista da Sociedade Brasileira de Medicina Tropical, 2003
Benznidazole is recommended in Brazil for the treatment of Trypanosoma cruzi infection in acute and early chronic phases of Chagas' disease. Observations by others have indicated a higher incidence of neoplasias in immunosuppressed patients, presenting ...
Sonia G. Andrade, Igor Marcelo Oliveira Mesquita, Jamile F. Jambeiro, Isis F. Magalhães Santos, Renata Siqueira Portella   +4 more
doaj  

In Vitro Benznidazole and Nifurtimox Susceptibility Profile of Trypanosoma cruzi Strains Belonging to Discrete Typing Units TcI, TcII, and TcV

Pathogens, 2019
We ascertain the in vitro Benznidazole (BZN) and Nifurtimox (NFX) susceptibility pattern of epimastigotes, trypomastigotes, and amastigotes of 21 T. cruzi strains, from patients, reservoir, and triatomine bugs of various geographic origins.
Susana Revollo, Bruno Oury, Andrea Vela, Michel Tibayrenc, Denis Sereno   +4 more
doaj   +1 more source

Molecular diagnosis and typing of Trypanosoma cruzi populations and lineages in cerebral Chagas disease in a patient with AIDS [PDF]

, 2005
Trypanosoma cruzi DNA was amplified from an intracranial biopsy and peripheral blood of an HIV patient with encephalitis; this episode was indicative of AIDS and congenital Chagas disease.
Altcheh, Jaime Marcelo, Begher, Sandra B., Bergher, Sandra B., Bisio, Margarita María Catalina, Burgos, Juan Miguel, Burgos, Juan Miguel, Deccarlini, Florencia, Duffy, Tomás, Freilij, Hector León, Freitas, Jorge M., Levalle, Jorge, Levin, Mariano Jorge, Lopez Alcoba, Horacio, Macedo, Andrea M., Schijman, Alejandro Gabriel, Teijeiro, Ricardo   +15 more
core   +1 more source

Co‐cultivation and Medium Optimization: A Strategy for Discovering Fungal‐derived Protease Inhibitors

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT The fungi Fusarium guttiforme and Phytophthora palmivora were cultivated in four different media (Potato Dextrose Agar, Czapek, rice, and ISP2) and co‐cultured to stimulate fungal interactions and enhance secondary metabolite production. Promising extracts were fractionated, yielding compounds such as the iron complex of fusaric acid (1 ...
Vitor de Souza Mazucato, Ludmilla Tonani, Marcia Regina von Zeska Kress, Adriano Defini Andricopulo, Gisele Barbosa, Renata Krogh, Leonardo Luiz Gomes Ferreira, Paulo Cezar Vieira   +7 more
wiley   +1 more source

Distinct Treatment Outcomes of Antiparasitic Therapy in Trypanosoma cruzi-Infected Children Is Associated With Early Changes in Cytokines, Chemokines, and T-Cell Phenotypes

Frontiers in Immunology, 2018
Background: In contrast to adults, Trypanosoma cruzi-infected children have more broadly functional Trypanosoma cruzi-specific T cells, and the total T-cell compartment exhibits fewer signs of immune exhaustion.
María C. Albareda, María A. Natale, Ana M. De Rissio, Marisa Fernandez, Alicia Serjan, María G. Alvarez, Gretchen Cooley, Huifeng Shen, Rodolfo Viotti, Jacqueline Bua, Melisa D. Castro Eiro, Myriam Nuñez, Laura E. Fichera, Bruno Lococo, Karenina Scollo, Rick L. Tarleton, Susana A. Laucella, Susana A. Laucella   +17 more
doaj   +1 more source

Preclinical pharmacokinetics of benznidazole [PDF]

British Journal of Cancer, 1984
Benznidazole is a lipophilic analogue of misonidazole (MISO) which shows promise as a chemosensitizer for clinical use, particularly in combination with CCNU. We have investigated the detailed pharmacokinetics of benznidazole in mice, dogs and sheep to provide a data base for the estimation of doses required for chemosensitization in man ...
P, Workman, R A, White, M I, Walton, L N, Owen, P R, Twentyman   +4 more
openaire   +2 more sources

Current and future chemotherapy for Chagas disease [PDF]

, 2015
Luís Gaspar is thankful to FCT for funding (scholarship reference: SFRH/BD/81604/2011). The research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreement No.602773 (Project KINDRED)
Cordeiro-da-Silva, Anabela, Coron, Ross P, Costantino, Luca, Costi, Maria Paola, Ferrari, Stefania, Freitas-Junior, Lucio H, Gaspar, Luís, McKerrow, James H, Moraes, Carolina B, Siqueira-Neto, Jair L, Smith, Terence Kenneth   +10 more
core   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Deep Eutectic Solvents in Polymeric Drug Carriers: Insights into Release Behavior and Functional Integration

ChemistryOpen, Volume 14, Issue 12, December 2025.
Incorporating deep eutectic solvents into polymer‐based drug delivery systems (DDS) offers a sustainable route to enhance solubility, modify drug release, and create dual‐function carriers. This review explores how DES influence polymer structures and DDS performance, highlighting future prospects in personalized, responsive pharmaceutical technologies.
Nining Nining, Yoga Windhu Wardhana, Taofik Rusdiana, Hariyanti Hariyanti   +3 more
wiley   +1 more source