Results 61 to 70 of about 12,752 (178)

Optical Absorption of the Antitrypanocidal Drug Benznidazole inWater

Molecules, 2014
UV-vis optical absorption spectra of the antitrypanocidal drug benznidazole solvated in water were measured for various concentrations. The spectra show a prominent peak around 3.80 eV, while deconvolution of the UV-vis optical absorption spectra ...
Eveline M. Bezerra, João R. Bezerra-Neto, Francisco A. M. Sales, Ricardo P. dos Santos, Alice M. C. Martins, Pedro de Lima-Neto, Ewerton W. S. Caetano, Eudenilson L. Albuquerque, Valder N. Freire   +8 more
doaj   +1 more source

Contemporary characteristics and outcomes in chagasic heart failure compared with other nonischemic and ischemic cardiomyopathy [PDF]

, 2017
Background: Chagas’ disease is an important cause of cardiomyopathy in Latin America. We aimed to compare clinical characteristics and outcomes in patients with heart failure (HF) with reduced ejection fraction caused by Chagas’ disease, with other ...
Claudio R. Gimpelewicz, Efraín A. Gómez, Felipe Martinez, Felix Ramires, Jean L. Rouleau, John J.V. McMurray, Karl Swedberg, Kenneth Dickstein, Lars Køber, Li Shen, Luis Eduardo Echeverría, Luiz Carlos Bodanese, Michael R. Zile, Milton Packer, null null, Pardeep S. Jhund, Scott D. Solomon, William T. Abraham   +17 more
core   +3 more sources

A Robust and Accurate Filter Paper–Based Dried Plasma Spot Method for Bictegravir Monitoring in HIV Therapy

Rapid Communications in Mass Spectrometry, Volume 39, Issue 21, 15 November 2025.
ABSTRACT Context Therapeutic drug monitoring (TDM) involves the collection of biological samples such as blood, plasma, urine, and saliva. The most commonly used biological matrix for the detection of drugs is either blood or plasma, as they are widely accepted by the regulatory authorities.
Arpita Sathyanarayanan, Roopashri N. Arekal, Divyashree Somashekara   +2 more
wiley   +1 more source

Stress-Induced Proliferation and Cell Cycle Plasticity of Intracellular Trypanosoma cruzi Amastigotes

mBio, 2018
The mammalian stages of the parasite Trypanosoma cruzi, the causative agent of Chagas disease, exhibit a wide host species range and extensive within-host tissue distribution.
Peter C. Dumoulin, Barbara A. Burleigh
doaj   +1 more source

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis [PDF]

, 2018
Interest in nitroheterocyclic drugs for the treatment of infectious diseases has undergone a resurgence in recent years. Here we review the current status of monocyclic and bicyclic nitroheterocyclic compounds as existing or potential new treatments for ...
Alan H. Fairlamb, Alliance T.B., Altcheh J., Andrade H.M., Andrade S.G., Andrade S.G., Andrews K.T., Ang C.W., Araldi R.P., Aubé J., Bahia M.T., Bahia M.T., Balasubramanian B., Barreto-Bergter E., Berriman M., Bisser S., Blumenstiel K., Boiani M., Brener Z., Bruhn D.F., Bustamante J.M., Campos M.C., Campos M.C., Chung M.C., Collins A.R., Darsaud A., de Andrade A.L., Deavall D.G., Dikhit M.R., Docampo R., Docampo R., Docampo R., Dodd M.C., Dogra M., El-Sayed N.M., Enanga B., Eperon G., Fabbro D.L., Fairlamb A.H., Fairlamb A.H., Fairlamb A.H., Fernández M.L., Ferreira R.C., Filardi L.S., Fonseca-Berzal C., Garavaglia P.A., Goijman S.G., Gupta S., Gurumurthy M., Hall B.S., Hall B.S., Hayashi M., Henderson G.B., Henderson G.B., Henriques C., Ivens A.C., Jacobs R.T., Janssens P.G., Jeganathan S., Jennings F.W., Kaiser M., Kubata B.K., Lewis M.D., Lewis M.D., Lewis M.D., Likeufack A.C.L., Maina N., Makarov V., Marin-Neto J.A., Marin-Neto J.A., Matsumoto M., Maya J.D., Mejia A.M., Mejía-Jaramillo A.M., Mesu V.K.B.K., Miura K., Moens F., Molina I., Moreno M., Moreno S.N.J., Morillo C.A., Morillo C.A., Mortelmans K., Mukherjee T., Mukkavilli R., Murta S.M., Murta S.M.F., Murta S.M.F., Neal R.A., Nesslany F., Nogoceke E., Nogueira F.B., Nogueira F.B., Olmo F., Panicucci R., Papadopoulou M.V., Papadopoulou M.V., Papadopoulou M.V., Patterson S., Patterson S., Patterson S., Portal P., Priotto G., Priotto G., Pépin J., Pépin J., Raether W., Repetto Y., Rodriques Coura J., Romero A.H., Ryan N.J., Sasahara K., Shimokawa Y., Singh R., Smith D.A., Sokolova A.Y., Stephen Patterson, Stover C.K., Stuart K., Tarleton R.L., Tarral A., Temperton N.J., Thompson A.M., Thompson A.M., Thompson A.M., Thompson A.M., Thompson A.M., Torreele E., Trochine A., Trochine A., Trunz B.B., Tweats D., Urbina J.A., Viodé C., Walsh J.S., Wilkinson S.R., Winkelmann E., Wyllie S., Wyllie S., Wyllie S., Wyllie S., Zhou L.   +141 more
core   +2 more sources

Exploring Bioactive Metabolites From Fusarium falciforme and Aspergillus terreus Isolated From Protease‐Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities

Chemistry &Biodiversity, Volume 22, Issue 11, November 2025.
Metabolites from fungi isolated from protease rich‐fruits displayed antifungal, antitrypanosomal and enzymatic inhibitory activities. ABSTRACT Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from
Gabriela de Oliveira Almeida, Vitor de Souza Mazucato, Ludmilla Tonani, Marcia Regina von Zeska Kress, Gisele Barbosa, Renata Krogh, Adriano Defini Andricopulo, Leonardo Luiz Gomes Ferreira, Paulo Cezar Vieira   +8 more
wiley   +1 more source

Linajes de Trypanosoma cruzi en pacientes con enfermedad de Chagas y coinfección por VIH [PDF]

, 2009
Introducción. Las poblaciones naturales de T. cruzi han sido clasificadas en seis linajes filogenéticos o unidades de tipificación discreta: T. cruzi I, IIa, IIb, IIc, IId y IIe, que pueden jugar un rol en el tropismo tisular y patogénesis de la ...
Altcheh, Jaime Marcelo, Begher, Sandra, Bisio, Margarita María Catalina, Burgos, Juan Miguel, Cura, Carolina Inés, Duffy, Tomás, Freilij, Hector León, Giganti, Salvador Óscar, Levin, Mariano Jorge, Scapellato, Pablo Gustavo, Schijman, Alejandro Gabriel, Schreck, Ricardo   +11 more
core  

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins

Química Nova, 2011
This study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were obtained in solution, presenting 1:1
José Lamartine Soares Sobrinho, Mônica Felts de La Roca Soares, Juan Jose Torres Labandeira, Lariza Darlene Santos Alves, Pedro José Rolim Neto   +4 more
doaj   +1 more source

A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imaging. [PDF]

, 2014
The protozoan Trypanosoma cruzi is the causative agent of Chagas disease, one of the world's major neglected infections. Although development of improved antiparasitic drugs is considered a priority, there have been no significant treatment advances in ...
Francisco, Amanda Fortes, Kelly, John M, Lewis, Michael D, Taylor, Martin C   +3 more
core   +1 more source