Results 71 to 80 of about 12,752 (178)

Variation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains

Memorias do Instituto Oswaldo Cruz, 2001
In this work, the susceptibility to benznidazole of two parental Trypanosoma cruzi strains, Colombian and Berenice-78, was compared to isolates obtained from dogs infected with these strains for several years.
Veloso VM, Carneiro CM, Toledo MJO, Lana M, Chiari E, Tafuri WL, Bahia MT   +6 more
doaj  

Novel cruzain inhibitors for the treatment of Chagas' disease. [PDF]

, 2012
The protozoan parasite Trypanosoma cruzi, the etiological agent of Chagas' disease, affects millions of individuals and continues to be an important global health concern.
Arkin, Michelle R, Doak, Allison, Durrant, Jacob D, Keränen, Henrik, McCammon, J Andrew, Ratnam, Joseline, Rogers, Kathleen E   +6 more
core   +1 more source

Natural Products from Mexican Medicinal Plants as Promising Trypanocidal Drugs

ChemistrySelect, Volume 10, Issue 37, October 6, 2025.
Chagas disease (American Trypanosomiasis) is caused by the protozoan Trypanosoma cruzi. Worldwide it is one of the seventeen neglected tropical diseases. There is a need of new drugs. This review assesses the literature (2012‐2024) of secondary metabolites isolated from Mexican plants active against this parasite.
Karla Daniela Rodríguez‐Hernández, Elia Guadalupe Jaimes‐Castelán, Ricardo Reyes‐Chilpa   +2 more
wiley   +1 more source

In vitro and in vivo experimental models for drug screening and development for Chagas disease

Memorias do Instituto Oswaldo Cruz, 2010
Chagas disease, a neglected illness, affects nearly 12-14 million people in endemic areas of Latin America. Although the occurrence of acute cases sharply has declined due to Southern Cone Initiative efforts to control vector transmission, there still ...
Alvaro José Romanha, Solange Lisboa de Castro, Maria de Nazaré Correia Soeiro, Joseli Lannes-Vieira, Isabela Ribeiro, André Talvani, Bernadette Bourdin, Bethania Blum, Bianca Olivieri, Carlos Zani, Carmenza Spadafora, Egler Chiari, Eric Chatelain, Gabriela Chaves, José Eduardo Calzada, Juan Manuel Bustamante, Lucio H Freitas-Junior, Luz I Romero, Maria Terezinha Bahia, Michel Lotrowska, Milena Soares, Sonia Gumes Andrade, Tanya Armstrong, Wim Degrave, Zilton de Araújo Andrade   +24 more
doaj   +1 more source

Longitudinal study of patients with chronic Chagas cardiomyopathy in Brazil (SaMi-Trop project): a cohort profile. [PDF]

, 2016
PurposeWe have established a prospective cohort of 1959 patients with chronic Chagas cardiomyopathy to evaluate if a clinical prediction rule based on ECG, brain natriuretic peptide (BNP) levels, and other biomarkers can be useful in clinical practice ...
Bierrenbach, Ana Luiza, Cardoso, Clareci Silva, Cunha-Neto, Edécio, de Oliveira, Lea Campos, Ferreira, Ariela Mota, Ferreira, João Eduardo, Haikal, Desirée Sant'Ana, Oliveira, Claudia Di Lorenzo, Reingold, Arthur L, Ribeiro, Antonio Luiz P, Sabino, Ester Cerdeira   +10 more
core   +3 more sources

Enantioselective Properties of Neglected Drug Nifurtimox on Polysaccharide and Macrocyclic Glycopeptide Chiral Stationary Phases by Green HPLC Separation Methods

Journal of Separation Science, Volume 48, Issue 9, September 2025.
ABSTRACT Nifurtimox (NFX) is a chiral drug used for the treatment of Chagas Disease. Little attention has been paid to the enantioselective properties of chiral drugs used for neglected tropical diseases, highlighting the need for further studies in this area.
Amanda Mohr, Érika Segala, Gustavo Machado das Neves, Vera Lucia Eifler‐Lima, Martin Steppe   +4 more
wiley   +1 more source

Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease [PDF]

, 2010
Therapeutic failure of benznidazole (BZ) is widely documented in Chagas disease and has been primarily associated with variations in the drug susceptibility of Trypanosoma cruzi strains.
CHIARI, Egler, D'ÁVILA, Daniella A, GALVÃO, Lúcia MC, GONTIJO, Eliane D, MACEDO, Andrea M, MORENO, Margoth, SILVA, Marcelo N, ZINGALES, Bianca   +7 more
core   +3 more sources

Chagas disease screening of maternal donors in publicly banked umbilical cord blood in North Carolina, United States 2007–2023

Pregnancy, Volume 1, Issue 4, July 2025.
Abstract Introduction Over 300,000 people living in the United States are estimated to have Chagas disease, a condition for which mother to child transmission may occur and early diagnosis is essential to reduce Chagas‐related morbidity and mortality. This study evaluated positive Trypanosoma cruzi (T. cruzi) screening serology among maternal donors of
Naseem Alavian, Susan Izatt, Robert J. Rolfe, Jose Hernandez, Joanne Kurtzberg, Lynn Martin, Elizabeth Livingston   +6 more
wiley   +1 more source

Comparisons between Crystallography Data and Theoretical Parameters and the Formation of Intramolecular Hydrogen Bonds: Benznidazole

Crystals, 2016
The conformational preferences of benznidazole were examined through the application of DFT, PCM and QTAIM calculations, whose results were compared with crystallography data.
Boaz G. Oliveira, Edilson B. Alencar Filho, Mário L. A. A. Vasconcellos   +2 more
doaj   +1 more source

Natural selection and genetic variation in a promising Chagas disease drug target: Trypanosoma cruzi trans-sialidase [PDF]

, 2017
Rational drug design is a powerful method in which new and innovative therapeutics can be designed based on knowledge of the biological target aiming to provide more efficacious and responsible therapeutics.
Gallant, Joseph P.
core   +1 more source