Results 81 to 90 of about 12,752 (178)

The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice [PDF]

, 2010
The activity of the antineoplastic drug tamoxifen was evaluated against Trypanosoma cruzi. In vitro activity was determined against epimastigote, trypomastigote and amastigote forms of CL14, Y and Y benznidazole resistant T. cruzi strains.
ALVES, Rosana de Oliveira, FERRAZ, Marcela Lencine, MIGUEL, Danilo Ciccone, ROMANHA, Alvaro José, TORRECILHAS, Ana Claudia, ULIANA, Silvia RB, YOKOYAMA-YASUNAKA, Jenicer KU   +6 more
core   +3 more sources

Synthesis of Quinic Acid‐Derived Sialylmimetics and Their Effects on T. cruzi and Trans‐Sialidase

ChemistrySelect, Volume 10, Issue 16, April 25, 2025.
The synthesis of sialylmimetic hybrids using quinic and shikimic acids as precursors was achieved in a single synthetic route to produce two isomers (5S‐ and 5R), incorporating the 4‐(4‐nitrophenyl)‐1H‐1,2,3‐triazole units, as novel leads for Chagas disease treatment.
Dayan Setton Amancio, Guilherme Martins da Silva, Carlos Henrique Tomich de Paula da Silva, Luis Otávio Bunhotto Zamoner, Lizandra Guidi Magalhães, Guilherme Cecilio Lima, Mariana Zaramello da Paixão, Ivone Carvalho   +7 more
wiley   +1 more source

Up-regulation of ATP-binding cassette transporters in the THP-1 human macrophage cell line by the antichagasic benznidazole

Memorias do Instituto Oswaldo Cruz
The effect of benznidazole (BZL) on the expression and activity of P-glycoprotein (P-gp, ABCB1) and multidrug resistance-associated protein 2 (MRP2, ABCC2), the two major transporters of endogenous and exogenous compounds, was evaluated in differentiated
Virginia G Perdomo, Juan P Rigalli, Marcelo G Luquita, José M Pellegrino, María Laura Ruiz, Viviana A Catania   +5 more
doaj   +1 more source

Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans

Memorias do Instituto Oswaldo Cruz, 2005
Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were
Edilson N Kaneshima, Marialba A Alves de Castro-Prado   +1 more
doaj   +1 more source

Reactivation of Chagas Disease in the Central Nervous System Among Heart Transplant Recipients: A Clinical Series From Brazil, 2006–2023

Transplant Infectious Disease, Volume 27, Issue 2, March/April 2025.
ABSTRACT Background Chagas disease is a relevant cause of heart transplantation. The risk of reactivation is a potential concern. This study aimed to describe the reactivation of Trypanosoma cruzi in the central nervous system (CNS). Methods We performed a retrospective study of all heart transplants for Chagas disease undertaken between 2006 and 2023 ...
Jacqueline Ferreira de Oliveira, Ana Luiza Barbosa, Gláucia Cota, Fábio Morato de Castilho, Silvio Amadeu de Andrade, Guilherme Ferraz Messina de Pádua Andrade, Juliana Rodrigues Soares Oliveira, Paulo Pereira Christo, Breno Franco Silveira Fernandes, Rodrigo Santiago Gomez, Israel Molina   +10 more
wiley   +1 more source

Nanomedicines against Chagas disease: a critical review

Beilstein Journal of Nanotechnology
Chagas disease (CD) is the most important endemic parasitosis in South America and represents a great socioeconomic burden for the chronically ill and their families.
Maria Jose Morilla, Kajal Ghosal, Eder Lilia Romero   +2 more
doaj   +1 more source

Clinical and laboratory status of patients with chronic Chagas disease living in a vector-controlled area in Minas Gerais, Brazil, before and nine years after aetiological treatment

Memorias do Instituto Oswaldo Cruz, 2009
Twenty-eight Chagas disease patients (CD), 22 with the indeterminate clinical form (IND) and six with the cardiac or digestive form (CARD/DIG), were treated with benznidazole and underwent clinical and laboratorial analysis before (IND and CARD/DIG) and ...
Marta de Lana, Leonardo A Lopes, Helen R Martins, Maria T Bahia, Girley F Machado-de-Assis, Ana P Wendling, Olindo A Martins-Filho, Roberto A Montoya, João CP Dias, Pedro Albajar-Viñas, José R Coura   +10 more
doaj   +1 more source

Antiprotozoal activity of flavonoids from Eupatorium arnottianum [PDF]

, 2017
Dichloromethane and ethanol extracts of Eupatorium arnottianum were evaluated for invitroleishmanicidal activity. The dichloromethane extract produced 80% and 85% of growthinhibition on both Leishmania mexicana and Leishmania amazonensis promastigotes ...
Cazorla, Silvia Ines, Clavin, Maria Liliana, Frank, Fernanda María, Malchiodi, Emilio Luis, Martino, Virginia Susana, Muschietti, Liliana Victoria, Sosa, Miguel Angel, Spina Zapata, Renata María   +7 more
core  

Lymphocyte Transformation Test (LTT) in Allergy to Benznidazole: A Promising Approach

Frontiers in Pharmacology, 2019
Benznidazole (Bzn) from the nitroimidazole family and nifurtimox from nitrofurans family, are drugs used as first and second line treatment for acute and chronic phases of Chagas disease (CD). Even though skin reactions are frequent, confirmed allergy to
M. Andreína Marques-Mejías, Rosario Cabañas, Rosario Cabañas, Rosario Cabañas, Elena Ramírez, Elena Ramírez, Javier Domínguez-Ortega, Javier Domínguez-Ortega, Ana Fiandor, Ana Fiandor, Elena Trigo, Elena Trigo, Santiago Quirce, Santiago Quirce, Teresa Bellón, Teresa Bellón   +15 more
doaj   +1 more source

Congenital Chagas disease in a Bolivian newborn in Bergamo (Italy) [PDF]

, 2018
Chagas disease (CD) is an uncommon disease in Europe. Its epidemiology has changed because of mass migration from Latin America to Europe. Herein we describe a congenital case of CD in a Bolivian newborn in Bergamo, the main city of residence for the ...
Bargiggia, Graziano, D'Antiga, Lorenzo, Farina, Claudio, Gabrielli, Simona, Ortalli, Gaia, Rodari, Paola, Ruggeri, Maurizio   +6 more
core